Anthralin (Dritho-Scalp)
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Anthralin (Dritho-Scalp)

Dritho-Scalp®
(anthralin) Topical Cream

Important Information about Dritho-Scalp®

Warning - Dritho-Scalp® can cause severe irritation. Be careful to keep off skin not affected by psoriasis. Rinse immediately after 5 minutes or the amount of time your doctor prescribed. If irritation occurs, discontinue use and call your doctor. Keep away from eyes.

Caution - Dritho-Scalp® can permanently stain clothing and bathroom fixtures. Dritho-Scalp will also stain skin, but skin staining is temporary. Use only old clothing and old towels and linens when using Dritho-Scalp. Any clothing or linens that come in contact with Dritho-Scalp may become permanently stained. Rinse all bathroom fixtures immediately and thoroughly.

DRUG DESCRIPTION

Dritho-Scalp® is a pale yellow topical cream containing 0.5% anthralin USP in a base of white petrolatum, mineral oil, sodium lauryl sulfate, cetostearyl alcohol, ascorbic acid, salicylic acid, methylparaben and purified water. The chemical name of anthralin is l,8-dihydroxy-9- anthrone. The structural formula is:

Dritho-Scalp (anthralin) Structural Formula Illustration

What are the precautions when taking anthralin (Dritho-Scalp)?

Before using anthralin, tell your doctor or pharmacist if you are allergic to it; or to preservatives (e.g., parabens); or if you have any other allergies. This product may contain other inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease.

To prevent staining of clothing or bed linen, a protective dressing may be useful. To prevent staining of the tub or shower (after washing off the medicine), rinse tub/shower with lukewarm water. Then use a cleanser to remove any deposits left on the surface.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and...

Read All Potential Precautions of Dritho-Scalp »

Last reviewed on RxList: 5/26/2011
This monograph has been modified to include the generic and brand name in many instances.

INDICATIONS

An aid in the topical treatment of quiescent or chronic psoriasis of the scalp. Treatment should be continued until the skin is entirely clear, i.e., when there is nothing to feel with the fingers and the texture is normal.

DOSAGE AND ADMINISTRATION

Generally, it is recommended that Dritho-Scalp be applied once a day or as directed by a physician. Anthralin is known to be a potential skin irritant. The irritant potential of anthralin is directly related to each patient's individual tolerance. Therefore, where the response to anthralin treatment has not previously been established, always commence treatment using a short contact time of 5 to 10 minutes for at least one week using Dritho-Scalp. Contact time can be increased stepwise to twenty to thirty minutes, or as directed by a physician, before removing the cream by thoroughly washing or showering. Apply as directed by a physician. The optimal period of contact will vary according to the patient's response to treatment.

To open the tube, unscrew the cap and invert to pierce the membrane. Comb the hair to remove scalar debris and, after suitably parting, apply Dritho-Scalp only to the lesions and rub in well, taking care to prevent the cream spreading onto the forehead.

Keep Dritho-Scalp well away from the eyes.

Avoid application of the cream to uninvolved scalp margins. Remove any unintended residue which may be deposited behind the ears. At the end of each period of contact, wash the hair and scalp to remove any surplus cream (which may have become red/brown in color).

Always wash hands thoroughly after use.

Store at controlled room temperature, 15-30C (59-86F).

HOW SUPPLIED

50 g tube

Manufacturer details: n/a

Last reviewed on RxList: 5/26/2011
This monograph has been modified to include the generic and brand name in many instances.

SIDE EFFECTS

Very few instances of contact allergic reactions to anthralin have been reported. However, transient primary irritation of uninvolved skin surrounding the treated lesions is more frequently seen and may occasionally be severe. Application of Dritho-Scalp must be restricted to the psoriatic lesions. If the initial treatment produces excessive soreness or if the lesions spread, reduce frequency of application and, in extreme cases, discontinue use and consult physician. Some temporary discoloration of hair and fingernails may arise during the period of treatment but should be minimized by careful application. Dritho-Scalp may stain skin, hair or fabrics. Staining of fabrics may be permanent, so contact should be avoided.

Read the Dritho-Scalp (anthralin) Side Effects Center for a complete guide to possible side effects »

DRUG INTERACTIONS

No information provided.

Last reviewed on RxList: 5/26/2011
This monograph has been modified to include the generic and brand name in many instances.

WARNINGS

Avoid contact with the eyes or mucous membranes. Dritho-Scalp should not normally be applied to intertriginous skin areas and high strengths should not be used on these sights. Remove any unintended residue which may be deposited behind the ears. Avoid applying to the folds and creases of the skin. Discontinue use if a sensitivity reaction occurs or if excessive irritation develops on uninvolved skin areas. Keep out of the reach of children.

PRECAUTIONS

For external use only. Dritho-Scalp may stain the hair and should be applied sparingly and carefully to psoriatic lesions only. Contact with fabrics, plastics and other materials may cause staining and should be avoided. To prevent the possibility of discoloration, always rinse the bath/shower with hot water immediately after washing/showering and then use a suitable cleanser to remove any deposit on the surface of the bath or shower. Always wash hands thoroughly after use, 15-30° C (59-86° F). Long-term studies in animals have not been performed to evaluate the carcinogenic potential of the drug. Although anthralin has been found to have tumor-promoting properties on mouse skin, there have been no reports to suggest carcinogenic effects in humans after many years of clinical use. As long-term use of topical corticosteroids may destabilize psoriasis, and withdrawal may also give rise to a 'rebound' phenomenon, an interval of at least one week should be allowed between the discontinuance of such steroids and the commencement of Dritho-Scalp therapy. Petrolatum or a suitably bland emollient may usefully be applied during the intervening period.

Pregnancy

Pregnancy Category C. Animal reproduction studies have not been conducted with Dritho-Scalp. It is also not known whether Dritho-Scalp can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Dritho-Scalp should be given to a pregnant woman only if clearly needed.

Nursing Mothers

It is not known whether this drug is excreted in human milk. Because many drugs are excreted in milk and because of the potential for tumorigenicity shown for anthralin in animal studies, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Pediatric Use

Safety and effectiveness in pediatric patients have not been established.

Last reviewed on RxList: 5/26/2011
This monograph has been modified to include the generic and brand name in many instances.

OVERDOSE

No information provided.

CONTRAINDICATIONS

In patients with acute psoriatic eruptions or a history of hypersensitivity to any of the ingredients.

Last reviewed on RxList: 5/26/2011
This monograph has been modified to include the generic and brand name in many instances.

CLINICAL PHARMACOLOGY

Although the precise mechanism of anthralin's anti-psoriatic action is not fully understood, in vitro evidence suggests that its antimitotic effect results from inhibition of DNA synthesis. Additionally, the chemically reducing properties of anthralin may upset oxidative metabolic processes, providing a further slowing down of epidermal mitosis. Absorption in man has not been finally determined, but in a limited clinical study of anthralin cream, no traces of anthraquinone metabolites were detected in the urine of subjects treated; however, caution is advised in patients with renal disease.

Last reviewed on RxList: 5/26/2011
This monograph has been modified to include the generic and brand name in many instances.

PATIENT INFORMATION

Easy Dritho-Scalp® Application Instructions

  1. Wet your scalp thoroughly.
  2. Wet your scalp thoroughly - illustration

  3. Part off your hair one inch at a time to examine and treat each plaque.
  4. Wearing disposable gloves, apply a "pea size" drop of Dritho-Scalp® directly to all plaques by rubbing in thoroughly but gently. Avoid ears, eyes and neck, and be careful not to smear on unaffected skin. Tip: Petroleum jelly can be applied to ear folds and neck to minimize contact and avoid irritation.
  5. Apply a "pea size" drop of Dritho-Scalp - illustration

  6. Cover scalp with shower cap to prevent staining and smearing. Line the edges of the cap with cotton coil or folded tissues.
  7. Cover scalp with shower cap - illustration

  8. Do not leave Dritho-Scalp® on any longer than directed by your dermatologist. Remove immediately when time is up.
  9. Remove immediately when time is up  - illustration

  10. Shampoo out thoroughly but gently. Lean head back when rinsing to avoid Dritho-Scalp® contact with the face and eyes. If it gets into your eyes or on your face, rinse thoroughly and call your dermatologist.
  11. Immediately clean the shower or bathroom fixture, rinsing thoroughly. Dishwashing detergent may help to remove residue.
  12. Dry off with an old towel as staining of fabrics is permanent.
  13. Dry off with an old towel - illustration

Last reviewed on RxList: 5/26/2011
This monograph has been modified to include the generic and brand name in many instances.

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PATIENT INFORMATION

Easy Dritho-Scalp® Application Instructions

  1. Wet your scalp thoroughly.
  2. Wet your scalp thoroughly - illustration

  3. Part off your hair one inch at a time to examine and treat each plaque.
  4. Wearing disposable gloves, apply a "pea size" drop of Dritho-Scalp® directly to all plaques by rubbing in thoroughly but gently. Avoid ears, eyes and neck, and be careful not to smear on unaffected skin. Tip: Petroleum jelly can be applied to ear folds and neck to minimize contact and avoid irritation.
  5. Apply a "pea size" drop of Dritho-Scalp - illustration

  6. Cover scalp with shower cap to prevent staining and smearing. Line the edges of the cap with cotton coil or folded tissues.
  7. Cover scalp with shower cap - illustration

  8. Do not leave Dritho-Scalp® on any longer than directed by your dermatologist. Remove immediately when time is up.
  9. Remove immediately when time is up  - illustration

  10. Shampoo out thoroughly but gently. Lean head back when rinsing to avoid Dritho-Scalp® contact with the face and eyes. If it gets into your eyes or on your face, rinse thoroughly and call your dermatologist.
  11. Immediately clean the shower or bathroom fixture, rinsing thoroughly. Dishwashing detergent may help to remove residue.
  12. Dry off with an old towel as staining of fabrics is permanent.
  13. Dry off with an old towel - illustration

Last reviewed on RxList: 5/26/2011
This monograph has been modified to include the generic and brand name in many instances.

Disclaimer

Dritho-Scalp Consumer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

ANTHRALIN (FOR SCALP ONLY) - TOPICAL

(AN-thra-lin)

COMMON BRAND NAME(S): Dritho-Scalp

USES: This medication is used for the treatment of long-term psoriasis of the scalp. Anthralin is a man-made version of a natural substance found in goa powder, which is from the araroba tree. It works by slowing down the growth of skin cells. This product does not contain a corticosteroid or coal tar. It is not meant to be used for a severe outbreak of psoriasis. Do not use this drug if the skin is inflamed or irritated.

HOW TO USE: Exactly follow all directions from your doctor and pharmacist. Learn how to apply this medicine, how long to leave it on the scalp, and how to avoid staining.

This medication is for use on the scalp.

To prevent discoloration of fingernails, apply this medication using plastic gloves.

Apply a thin layer to the area with psoriasis, usually once daily. Avoid the normal scalp. Rub in well. If normal skin surrounding the treated areas becomes too irritated, you may cover the normal skin with petroleum jelly to protect it.

Wash hair first with a shampoo to remove loose scales. Rinse off the shampoo, then apply this medication as directed, only on the psoriasis area.

Follow your doctor's directions for how long to leave the drug on the scalp (usually starting at 5-10 minutes per treatment). Then wash the scalp with a recommended shampoo and rinse well.

After using this medicine, wash hands with plenty of soap and water.

Do not allow the drug to come in contact with the eyes or the inside of the nose/mouth. If this occurs, flush with plenty of water. If irritation occurs, contact your doctor immediately.

Treatment is usually continued until the affected area is entirely clear.

Tell your doctor if your condition persists or worsens.

Disclaimer

Dritho-Scalp Consumer (continued)

SIDE EFFECTS: Temporary redness or irritation of the treated scalp may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: increased soreness of skin, spread of psoriasis.

This medication may temporarily discolor fingernails or discolor gray/white hair. It will also stain skin and fabrics (see also Precautions section).

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the Dritho-Scalp (anthralin) Side Effects Center for a complete guide to possible side effects »

PRECAUTIONS: Before using anthralin, tell your doctor or pharmacist if you are allergic to it; or to preservatives (e.g., parabens); or if you have any other allergies. This product may contain other inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease.

To prevent staining of clothing or bed linen, a protective dressing may be useful. To prevent staining of the tub or shower (after washing off the medicine), rinse tub/shower with lukewarm water. Then use a cleanser to remove any deposits left on the surface.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Disclaimer

Dritho-Scalp Consumer (continued)

DRUG INTERACTIONS: Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially: other skin products or shampoos used for psoriasis, corticosteroids (e.g., triamcinolone, amcinonide creams).

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

OVERDOSE: This medication may be harmful if swallowed. If swallowing or overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center.

NOTES: Do not share this medication with others.

This medication has been prescribed for your current condition only. Do not use it later for another skin condition unless told to do so by your doctor. A different medication may be necessary in that case.

MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

STORAGE: Store at room temperature between 59-86 degrees F (15-30 degrees C) away from heat and light. Keep container tightly closed. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised October 2010. Copyright(c) 2010 First Databank, Inc.

Dritho-Scalp®
(anthralin) Topical Cream

Important Information about Dritho-Scalp®

Warning - Dritho-Scalp® can cause severe irritation. Be careful to keep off skin not affected by psoriasis. Rinse immediately after 5 minutes or the amount of time your doctor prescribed. If irritation occurs, discontinue use and call your doctor. Keep away from eyes.

Caution - Dritho-Scalp® can permanently stain clothing and bathroom fixtures. Dritho-Scalp will also stain skin, but skin staining is temporary. Use only old clothing and old towels and linens when using Dritho-Scalp. Any clothing or linens that come in contact with Dritho-Scalp may become permanently stained. Rinse all bathroom fixtures immediately and thoroughly.

DRUG DESCRIPTION

Dritho-Scalp® is a pale yellow topical cream containing 0.5% anthralin USP in a base of white petrolatum, mineral oil, sodium lauryl sulfate, cetostearyl alcohol, ascorbic acid, salicylic acid, methylparaben and purified water. The chemical name of anthralin is l,8-dihydroxy-9- anthrone. The structural formula is:

Dritho-Scalp (anthralin) Structural Formula Illustration

Last reviewed on RxList: 5/26/2011
This monograph has been modified to include the generic and brand name in many instances.

Dritho-Scalp®
(anthralin) Topical Cream

Important Information about Dritho-Scalp®

Warning - Dritho-Scalp® can cause severe irritation. Be careful to keep off skin not affected by psoriasis. Rinse immediately after 5 minutes or the amount of time your doctor prescribed. If irritation occurs, discontinue use and call your doctor. Keep away from eyes.

Caution - Dritho-Scalp® can permanently stain clothing and bathroom fixtures. Dritho-Scalp will also stain skin, but skin staining is temporary. Use only old clothing and old towels and linens when using Dritho-Scalp. Any clothing or linens that come in contact with Dritho-Scalp may become permanently stained. Rinse all bathroom fixtures immediately and thoroughly.

DRUG DESCRIPTION

Dritho-Scalp® is a pale yellow topical cream containing 0.5% anthralin USP in a base of white petrolatum, mineral oil, sodium lauryl sulfate, cetostearyl alcohol, ascorbic acid, salicylic acid, methylparaben and purified water. The chemical name of anthralin is l,8-dihydroxy-9- anthrone. The structural formula is:

Dritho-Scalp (anthralin) Structural Formula Illustration

Last reviewed on RxList: 5/26/2011
This monograph has been modified to include the generic and brand name in many instances.

Dritho-Scalp®
(anthralin) Topical Cream

Important Information about Dritho-Scalp®

Warning - Dritho-Scalp® can cause severe irritation. Be careful to keep off skin not affected by psoriasis. Rinse immediately after 5 minutes or the amount of time your doctor prescribed. If irritation occurs, discontinue use and call your doctor. Keep away from eyes.

Caution - Dritho-Scalp® can permanently stain clothing and bathroom fixtures. Dritho-Scalp will also stain skin, but skin staining is temporary. Use only old clothing and old towels and linens when using Dritho-Scalp. Any clothing or linens that come in contact with Dritho-Scalp may become permanently stained. Rinse all bathroom fixtures immediately and thoroughly.

DRUG DESCRIPTION

Dritho-Scalp® is a pale yellow topical cream containing 0.5% anthralin USP in a base of white petrolatum, mineral oil, sodium lauryl sulfate, cetostearyl alcohol, ascorbic acid, salicylic acid, methylparaben and purified water. The chemical name of anthralin is l,8-dihydroxy-9- anthrone. The structural formula is:

Dritho-Scalp (anthralin) Structural Formula Illustration

Last reviewed on RxList: 5/26/2011
This monograph has been modified to include the generic and brand name in many instances.

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