Biltricide (Praziquantel)
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Biltricide (Praziquantel)

BILTRICIDE®
(praziquantel) Tablets

DRUG DESCRIPTION

BILTRICIDE® (praziquantel) is a trematodicide provided in tablet form for the oral treatment of schistosome infections and infections due to liver fluke.

BILTRICIDE (praziquantel) is 2-(cyclohexylcarbonyl)-1,2,3,6,7, 11b-hexahydro-4H-pyrazino [2, 1-a] isoquinolin-4-one with the molecular formula; C19H24N2O2. The structural formula is as follows:

BILTRICIDE® (praziquantel)  Structural Formula Illustration

Praziquantel is a white to nearly white crystalline powder of bitter taste. The compound is stable under normal conditions and melts at 136-140°C with decomposition. The active substance is hygroscopic. Praziquantel is easily soluble in chloroform and dimethylsulfoxide, soluble in ethanol and very slightly soluble in water.

BILTRICIDE tablets contain 600 mg of praziquantel. Inactive ingredients: corn starch, magnesium stearate, microcrystalline cellulose, povidone, sodium lauryl sulfate, polyethylene glycol, titanium dioxide and hypromellose.

What are the possible side effects of praziquantel (Biltricide)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects may include:

  • tired feeling;
  • headache, dizziness;
  • nausea, upset stomach;
  • mild fever; or
  • mild skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at...

Read All Potential Side Effects and See Pictures of Biltricide »

What are the precautions when taking praziquantel (Biltricide)?

Before taking praziquantel, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: parasitic eye infection (ocular cysticercosis).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease/enlarged spleen, heart disease/irregular heart rhythm, parasitic brain infection (cerebral cysticercosis), seizures.

This drug may make you dizzy or drowsy during treatment until the day after...

Read All Potential Precautions of Biltricide »

Last reviewed on RxList: 9/13/2010
This monograph has been modified to include the generic and brand name in many instances.

INDICATIONS

BILTRICIDE (praziquantel) is indicated for the treatment of infections due to: all species of schistosoma (for example, Schistosoma mekongi, Schistosoma japonicum, Schistosoma mansoni and Schistosoma hematobium), and infections due to the liver flukes, Clonorchis sinensis/Opisthorchis viverrini (approval of this indication was based on studies in which the two species were not differentiated).

DOSAGE AND ADMINISTRATION

The dosage recommended for the treatment of schistosomiasis is: 20 mg/kg bodyweight three times a day as a one day treatment, at intervals of not less than 4 hours and not more than 6 hours. The recommended dose for clonorchiasis and opisthorchiasis is: 25 mg/kg bodyweight three times a day as a one day treatment, at intervals of not less than 4 hours and not more than 6 hours. The tablets should be washed down unchewed with water during meals. Keeping the tablets or segments thereof in the mouth can reveal a bitter taste which can promote gagging or vomiting.

HOW SUPPLIED

BILTRICIDE (praziquantel) is supplied as a 600 mg white to orange tinged, film-coated, oblong tablet with three scores. The tablet is coded with “BAYER” on one side and “LG” on the reverse side. When broken, each of the four segments contains 150 mg of active ingredient so that the dosage can be easily adjusted to the patient's bodyweight.

Segments are broken off by pressing the score (notch) with thumbnails. If ¼ of a tablet is required, this is best achieved by breaking the segment from the outer end.

BILTRICIDE (praziquantel) is available in bottles of 6 tablets.

  Strength NDC
Bottles of 6 600 mg 0085-1747-01

Store below 86°F (30°C).

Manufactured by: Bayer HealthCare Pharmaceuticals Inc. Wayne, NJ 07470. Made in Germany. Distributed and Marketed by: Schering Corporation, a subsidiary of Whitehouse Station, NJ 08889, USA. Revised: 08/10.

Last reviewed on RxList: 9/13/2010
This monograph has been modified to include the generic and brand name in many instances.

SIDE EFFECTS

Adverse Events

In general BILTRICIDE (praziquantel) is very well tolerated. Side effects are usually mild and transient and do not require treatment. The following side effects were observed generally in order of severity: malaise, headache, dizziness, abdominal discomfort with or without nausea, rise in temperature and, rarely, urticaria. Such symptoms can, however, also result from the infection itself. Such side effects may be more frequent and/or serious in patients with a heavy worm burden.

Post Marketing Adverse Event Reports

Additional adverse events reported from worldwide post marketing experience and from publications with praziquantel include: abdominal pain, allergic reaction (generalized hypersensitivity) including polyserositis, anorexia, arrhythmia (including bradycardia, ectopic rhythms, ventricular fibrillation, AV blocks), asthenia, bloody diarrhea, convulsion, eosinophilia, myalgia, pruritis, somnolence, vertigo and vomiting.

Read the Biltricide (praziquantel) Side Effects Center for a complete guide to possible side effects »

DRUG INTERACTIONS

Concomitant administration of rifampin, a strong P450 inducer, with praziquantel is contraindicated and must be avoided (see CONTRAINDICATIONS). In a crossover study with a 2-week washout period, 10 healthy subjects ingested a single 40 mg/kg dose of praziquantel following pre-treatment with oral rifampin (600 mg daily for 5 days). Plasma praziquantel concentrations were undetectable in 7 out of 10 subjects. When a single 40 mg/kg dose of praziquantel was administered to these healthy subjects two weeks after discontinuation of rifampin, the mean praziquantel AUC and Cmax were 23% and 35% lower, respectively, than when praziquantel was given alone. In patients receiving rifampin, for example, as part of a combination regimen for the treatment of tuberculosis, alternative agents for schistosomiasis should be considered. However, if treatment with praziquantel is necessary, treatment with rifampin should be discontinued 4 weeks before administration of praziquantel. Treatment with rifampin can then be restarted one day after completion of praziquantel treatment.

Concomitant administration of other drugs that increase the activity of drug metabolizing liver enzymes (P450 inducers), for example, antiepileptic drugs (phenytoin, phenobarbital and carbamazepine), and dexamethasone, may also reduce plasma levels of praziquantel. Concomitant administration of drugs that decrease the activity of drug metabolizing liver enzymes (P 450 inhibitors), for example, cimetidine, ketoconazole, itraconazole, erythromycin may increase plasma levels of praziquantel.

Chloroquine, when taken simultaneously, may lead to lower concentrations of praziquantel in blood. The mechanism of this drug-drug interaction is unclear.

Grapefruit juice was reported to produce a 1.6-fold increase in the Cmax and a 1.9-fold increase in the AUC of praziquantel. However, the effect of this exposure increase on the therapeutic effect and safety of praziquantel has not been systematically evaluated.

Last reviewed on RxList: 9/13/2010
This monograph has been modified to include the generic and brand name in many instances.

WARNINGS

Therapeutically effective levels of BILTRICIDE (praziquantel) may not be achieved when administered concomitantly with strong P450 inducers, such as rifampin (see CONTRAINDICATIONS).

PRECAUTIONS

General

Approximately 80% of a dose of praziquantel is excreted in the kidneys, almost exclusively ( > 99%) in the form of metabolites. Excretion might be delayed in patients with impaired renal function, but accumulation of unchanged drug would not be expected. Therefore, dose adjustment for renal impairment is not considered necessary. Nephrotoxic effects of praziquantel or its metabolites are not known.

Caution should be exercised in the administration of the usual recommended dose of praziquantel to hepatosplenic schistosomiasis patients with moderate to severe liver impairment (Child-Pugh class B and C). Reduced metabolism of praziquantel by the liver in these patients may lead to considerably higher and longer lasting plasma concentrations of unmetabolized praziquantel (See CLINICAL PHARMACOLOGY/Special Populations).

Minimal increases in liver enzymes have been reported in some patients.

Patients suffering from cardiac irregularities should be monitored during treatment.

As BILTRICIDE (praziquantel) can exacerbate central nervous system pathology due to schistosomiasis, as a general rule this drug should not be administered to individuals reporting a history of epilepsy and/or other signs of potential central nervous systems involvement such as subcutaneous nodules suggestive of cysticercosis.

When schistosomiasis or fluke infection is found to be associated with cerebral cysticercosis it is advised to hospitalize the patient for the duration of treatment.

Mutagenesis, Carcinogenesis

Mutagenic effects in Salmonella tests found by one laboratory have not been confirmed in the same tested strain by other laboratories. Long term carcinogenicity studies in rats and golden hamsters did not reveal any carcinogenic effect.

Pregnancy Category B

Reproduction studies have been performed in rats and rabbits at doses up to 40 times the human dose and have revealed no evidence of impaired fertility or harm to the fetus due to praziquantel. There are, however, no adequate and well-controlled studies in pregnant women. An increase of the abortion rate was found in rats at three times the single human therapeutic dose. While animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.

Nursing mothers

Praziquantel appeared in the milk of nursing women at a concentration of about 1/4 that of maternal serum although it is not known whether a pharmacological effect is likely to occur in children. Women should not nurse on the day of BILTRICIDE (praziquantel) treatment and during the subsequent 72 hours.

Pediatric use

Safety in children under 4 years of age has not been established.

Geriatric use

Clinical studies of praziquantel did not include a sufficient number of subjects ages 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older patients cannot be ruled out.

This drug is known to be substantially excreted by the kidney. Because elderly patients are more likely to have decreased renal function, the risk of toxic reactions to this drug may be greater in these patients.

Last reviewed on RxList: 9/13/2010
This monograph has been modified to include the generic and brand name in many instances.

OVERDOSE

In rats and mice the acute LD50 was about 2,500 mg/kg. No data are available in humans. In the event of overdose a fast-acting laxative should be given.

CONTRAINDICATIONS

BILTRICIDE (praziquantel) is contraindicated in patients who previously have shown hypersensitivity to the drug or any of the excipients. Since parasite destruction within the eye may cause irreversible lesions, ocular cysticercosis must not be treated with this compound.

Concomitant administration with strong Cytochrome P450 (P450) inducers, such as rifampin, is contraindicated since therapeutically effective blood levels of praziquantel may not be achieved (see PRECAUTIONS: DRUG INTERACTIONS). In patients receiving rifampin who need immediate treatment for schistosomiasis, alternative agents for schistosomiasis should be considered. However, if treatment with praziquantel is necessary, rifampin should be discontinued 4 weeks before administration of praziquantel. Treatment with rifampin can then be restarted one day after completion of praziquantel treatment (see PRECAUTIONS: DRUG INTERACTIONS).

Last reviewed on RxList: 9/13/2010
This monograph has been modified to include the generic and brand name in many instances.

CLINICAL PHARMACOLOGY

Praziquantel induces a rapid contraction of schistosomes by a specific effect on the permeability of the cell membrane. The drug further causes vacuolization and disintegration of the schistosome tegument.

After oral administration BILTRICIDE (praziquantel) is rapidly absorbed (80%), subjected to a first pass effect, metabolized and eliminated by the kidneys. Maximal serum concentration is achieved 1-3 hours after dosing. The half-life of praziquantel in serum is 0.8-1.5 hours.

Special Populations

The pharmacokinetics of praziquantel were studied in 40 patients with Schistosoma mansoni infections with varying degrees of hepatic dysfunction (See table 1). In patients with schistosomiasis, the pharmacokinetic parameters did not differ significantly between those with normal hepatic function (Group 1) and those with mild (Child-Pugh class A) hepatic impairment. However, in patients with moderate-to-severe hepatic dysfunction (Child-Pugh class B and C), praziquantel half-life, Cmax, and AUC increased progressively with the degree of hepatic impairment. In Child-Pugh class B, the increases in mean half-life, Cmax, and AUC relative to Group 1 were 1.58-fold, 1.76-fold, and 3.55-fold, respectively. The corresponding increases in Child-Pugh class C patients were 2.82-fold, 4.29-fold, and 15-fold for half-life, Cmax, and AUC.

Table 1: Pharmacokinetic parameters of praziquantel in four groups of patients with varying degrees of liver function following administration of 40 mg/kg under fasting conditions.

Patient Group Half-life (hr) Tmax (hr) Cmax (μg/mL) AUC (μg/mL* hr)
Normal hepatic function (Group 1) 2.99 ± 1.28 1.48 ±0.74 0.83 ± 0.52 3.02 ±0.59
Child-Pugh A (Group 2) 4.66±2.77 1.37 ± 0.61 0.93± 0.58 3.87 ±2.44
Child-Pugh B (Group 3) 4.74 ±2.16a 2.21 ± 0.78a,b 1.47 ±0.74a,b 10.72 ±5.53a,b
Child-Pugh C (Group 4) 8.45 ±2.62a,b,c 3.2 ± 1.05a,b,c 3.57 ±1.30a,b,c 45.35 ± 17.50a,b,c
a) p < 0.05 compared to Group 1
b) p < 0.05 compared to Group 2
c) p < 0.05 compared to Group 3

Last reviewed on RxList: 9/13/2010
This monograph has been modified to include the generic and brand name in many instances.

PATIENT INFORMATION

Patients should be warned not to drive a car and not to operate machinery on the day of BILTRICIDE (praziquantel) treatment and the following day.

Last reviewed on RxList: 9/13/2010
This monograph has been modified to include the generic and brand name in many instances.

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PATIENT INFORMATION

Patients should be warned not to drive a car and not to operate machinery on the day of BILTRICIDE (praziquantel) treatment and the following day.

Last reviewed on RxList: 9/13/2010
This monograph has been modified to include the generic and brand name in many instances.

Disclaimer

Biltricide Consumer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

PRAZIQUANTEL - ORAL

(prazz-ih-KWAN-tull)

COMMON BRAND NAME(S): Biltricide

USES: This medication is used to treat infections of certain parasites (e.g., Schistosoma and liver flukes). Curing parasitic infections helps to improve your health and quality of life. Praziquantel belongs to a class of drugs known as antihelmintics. It works by killing the parasites. It also paralyzes the parasites, causing them to release their hold on the blood vessel walls so the body can remove them naturally.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This drug may also be used to treat infections of other parasites (e.g., tapeworms, intestinal and lung flukes).

HOW TO USE: Take this medication by mouth with food, usually 3 times a day (4 to 6 hours apart) for 1 day or as directed by your doctor. Quickly swallow the tablets or tablet segments with a full glass of water (8 ounces or 240 milliliters). Do not chew or suck the tablets because the bitter taste of praziquantel may cause gagging or vomiting. Your doctor may direct you to take this medication fewer than 3 times a day or to take it for longer than 1 day. Follow your doctor's directions exactly.

Dosage is based on your medical condition, weight, and response to treatment. Tablets are scored with lines. You may need to break the tablet to get the correct dose. Ask your pharmacist for directions on breaking the tablet to get the right dose for you.

Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor instructs you otherwise.

Tell your doctor if your condition persists or worsens.

Disclaimer

Biltricide Consumer (continued)

SIDE EFFECTS: Headache, dizziness, stomach pain, nausea, tiredness, weakness, joint/muscle pain, loss of appetite, vomiting, and sweating may occur. These side effects are usually mild and temporary and may be symptoms of your parasite infection and/or the dying parasites. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these rare but very serious side effects occur: bloody diarrhea, fever, irregular/slow heartbeat, seizures.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the Biltricide (praziquantel) Side Effects Center for a complete guide to possible side effects »

PRECAUTIONS: Before taking praziquantel, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: parasitic eye infection (ocular cysticercosis).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease/enlarged spleen, heart disease/irregular heart rhythm, parasitic brain infection (cerebral cysticercosis), seizures.

This drug may make you dizzy or drowsy during treatment until the day after treatment. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This drug passes into breast milk. Breast-feeding while using this drug is not recommended. Nursing mothers should temporarily stop breast-feeding on the day of treatment and for 72 hours after taking the last dose. Pump and discard breast milk during this time.

Disclaimer

Biltricide Consumer (continued)

DRUG INTERACTIONS: Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

This drug should not be used with the following medication because a very serious interaction may occur: rifampin.

If you are currently using the medication listed above, tell your doctor or pharmacist before starting praziquantel.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: chloroquine, drugs affecting liver enzymes that remove praziquantel from your body (e.g., cimetidine, dexamethasone, azole antifungals such as ketoconazole/itraconazole, macrolide antibiotics such as erythromycin, anti-seizure medicines such as carbamazepine/phenytoin/phenobarbital).

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center.

NOTES: Do not share this medication with others.

Laboratory and/or medical tests (e.g., examination of urine/stool, biopsy of infected tissue) should be performed periodically to monitor your progress or check for side effects. If you have a heart condition, you may need additional monitoring. Consult your doctor for more details.

MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

STORAGE: Store below 86 degrees F (30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised May 2010. Copyright(c) 2010 First Databank, Inc.

Biltricide Patient Information Including Side Effects

Brand Names: Biltricide

Generic Name: praziquantel (Pronunciation: PRAZ i KWON tel)

What is praziquantel (Biltricide)?

Praziquantel is an anthelmintic (an-thel-MIN-tik) or anti-worm medication. It prevents newly hatched insect larvae (worms) from growing or multiplying in your body.

Praziquantel is used to treat infections caused by Schistosoma worms, which enter the body through skin that has come into contact with contaminated water. Schistosoma worms are found in Africa, South America, Middle Eastern countries, the Caribbean, and parts of Asia.

Praziquantel is also used to treat infection with liver flukes, caused by a type of worm found in East Asia. This worm enters the body while eating contaminated fish.

Praziquantel should not be used to treat parasitic infections in the eye.

Praziquantel may also be used for purposes not listed in this medication guide.

What are the possible side effects of praziquantel (Biltricide)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects may include:

  • tired feeling;
  • headache, dizziness;
  • nausea, upset stomach;
  • mild fever; or
  • mild skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Biltricide (praziquantel) Side Effects Center for a complete guide to possible side effects »

What is the most important information I should know about praziquantel (Biltricide)?

You should not take this medicine if you are allergic to praziquantel, or if you have take rifampin (Rifadin, Rifater, Rifamate) in the last 4 weeks.

Before taking praziquantel, tell your doctor if you have kidney disease, heart disease, liver disease, or a history of seizures or epilepsy.

Do not give this medication to a child younger than 4 years old.

Praziquantel may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Praziquantel should be taken with a meal.

Do not crush or chew the praziquantel tablet. Swallow the pill whole.

Take this medication with a full glass (8 ounces) of water.

Side Effects Centers

Biltricide Patient Information including How Should I Take

What should I discuss with my healthcare provider before taking praziquantel (Biltricide)?

You should not take this medicine if you are allergic to praziquantel, or if you have take rifampin (Rifadin, Rifater, Rifamate) in the last 4 weeks.

To make sure you can safely take praziquantel, tell your doctor if you have any of these other conditions:

  • headaches, confusion;
  • seizures (or a history of seizures or epilepsy);
  • lumps (nodules) under your skin;
  • kidney disease;
  • heart disease; or
  • liver disease.

FDA pregnancy category B. Praziquantel is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Praziquantel can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Do not give this medication to a child younger than 4 years old.

How should I take praziquantel (Biltricide)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Take this medication with a full glass (8 ounces) of water.

Praziquantel is usually taken 3 times in one day. Your doses should be taken 4 to 6 hours apart on that day.

Praziquantel should be taken with a meal.

You may need to break a praziquantel tablet in order to get the correct dose. Follow your doctor's instructions.

Do not crush or chew the praziquantel tablet or portion of a tablet. Swallow the pill whole.

Store at room temperature away from moisture and heat.

Side Effects Centers

Biltricide Patient Information including If I Miss a Dose

What happens if I miss a dose (Biltricide)?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose (Biltricide)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking praziquantel (Biltricide)?

Praziquantel may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Grapefruit and grapefruit juice may interact with praziquantel and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.

What other drugs will affect praziquantel (Biltricide)?

Tell your doctor about all other medications you are using, especially:

  • cimetidine (Tagamet);
  • chloroquine (Aralen);
  • itraconazole (Sporanox) or ketoconazole (Extina, Ketozole, Nizoral, Xolegal);
  • dexamethasone (Decadron, Hexadrol);
  • erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin);
  • St. John's wort;
  • rifabutin (Mycobutin) or rifapentine (Priftin);
  • a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Solfoton);
  • HIV medication such as efavirenz (Sustiva, Atripla), etravirine (Intelence), nevirapine (Viramune), or ritonavir (Norvir, Kaletra);
  • medicines to treat narcolepsy, such as armodafanil (Nuvigil) or modafanil (Progivil); or
  • seizure medication such as carbamazepine (Carbatrol, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), or phenytoin (Dilantin), or primidone (Mysoline).

This list is not complete and other drugs may interact with praziquantel. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about praziquantel.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 6.01. Revision date: 2/14/2011.

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