Dynapen (Dicloxacillin)
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Dynapen (Dicloxacillin)

Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Dynapen
(dicloxacillin sodium)

DRUG DESCRIPTION

Dicloxacillin sodium is a semisynthetic antibiotic substance which resists destruction by the enzyme penicillinase (beta-lactamase). It is monosodium (2S,5R,6R)-6-(3-(2,6-dichlorophenyl)5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-OXO-4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylate monohydrate.

Dicloxacillin is administered orally via capsule form or powder for reconstitution.

Inactive Ingredients: Capsules: Magnesium Stearate.

  • Capsule Shell and print Constituents:
  • D& C Yellow #10 Aluminum Lake,
  • FD& C Blue #l Aluminum Lake,
  • FD& C Blue #2 Aluminum Lake,
  • FD& C Red #40 Aluminum Lake,
  • Gelatin, Pharmaceutical Glaze, Silicon Dioxide, Sodium Lauryl Sulfate, Synthetic Black Iron Oxide, Tiinium Dioxide and may contain Carboxymethylcellulose Sodium and/or Propylene Glycol.

What are the possible side effects of dicloxacillin (Dycill, Dynapen)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • diarrhea that is watery or bloody;
  • fever, chills, body aches, flu symptoms;
  • easy bruising or bleeding, unusual weakness;
  • urinating less than usual or not at...

Read All Potential Side Effects and See Pictures of Dynapen »

Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.

Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

INDICATIONS

Dicloxacillin is indicated in the treatment of infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drug. Cultures and susceptibility tests should be performed initialty to determine the causative organisms and their sensitivity to the drug. (see CLINICAL PHARMACOLOGY - Susceptibility plate Testing).

Dicloxacilin may be used to initiate therapy in suspected cases of resistant staphylococcal infections prior to the availability of laboratory test results. The penicillinase-resistant penicillins should not be used in infections caused by organisms susceptible to penicillin G. If the susceptibility tests indicate that the infection is due to an organism other than a resistant staphylococcus therapy should not be continued with a penicillinase-resistant penicillin.

DOSAGE AND ADMINISTRATION

Bacteriologic studies to determine the causative organisms and their sensitivity to the penicillinase-resistant penicillins should always be performed. Duration of therapy varies with the type and severity of infection as well as the overall condition of the patient, therefore it should be determined by the clinical and bacteriological response of the patient. In severe staphylococcal infections, therapy with penicillinase-resistant penicillins should be continued for at least 14 days. Therapy should be continued for at least 48 hours after the patient has become afebrile, asymptomatic and cultures are negative. The treatment of endocarditis and osteomyelitis may require a longer term of therapy.

Concurrent administration of the penicillinase-resistant penicillins and probenecid increases and prolongs serum penicillin levels.

Probencid decreases the apparent volume of distribution and slows the rate of excretion by competitively inhibiting renal tubular secretion of penicillin. Penicillin-probenecid therapy is generally limited to those infections where very high serum levels of penicillin are necessary.

Oral preparations of the penicillinase-resistant penicillins should not be used as initial therapy in serious, life-threatening infections (see PRECAUTIONS - General). Oral therapy with the penicillinase-resistant penicillins may be used to follow up the previous use of a parenteral agent as soon as the clinical condition warrants. for Intramuscular gluteal injections, care should be taken to avoid sciatic nerve injury. With intravenous administration, particularly in elderly patients, care should be taken because of the possibility of thrombophlebitis.

NB: INFECTIONS CAUSED BY GROUP A BETA-HEMOLYTIC STREPTOCOCCI SHOULD BE TREATED FOR AT LEAST 10 DAYS TO HELP PREVENT THE OCCURRENCE OF ACUTE RHEUMATIC FEVER OR ACUTE GLOMERULONEPHRITIS.

HOW SUPPLIED

Dicloxacillin Sodium Capsules, USP.

250 mg: Each capsule contains dicloxacillin sodium monohydrate equivalent to 250 mg dicloxacillin, with a light green cap and body imprinted "biocraft 02", available in bottles of 40, 100, 500 and Unit Dose cartons of 100 (10 x 10).

500 mg: Each capsule contains dicloxacillin sodium monohydrate equivalent to 500 mg dicloxacillin. with a light green cap and body imprinted "biocraft 04", available in bottles of 30, 40, 50, 100, 500 and Unit Dose cartons of 100 (10 x 10).

Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.

Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

SIDE EFFECTS

Body as a Whole

The reported incidence of allergic reactions to penicillin ranges from 0.7% to 10% (see WARNINGS). Sensitization is usually the result of treatment, but some individuals have had immediate reactions to penicillin when first treated in such cases it is thought that the patients may have had prior exposure to the drug via trace amounts present in milk and vaccines.

Two types of allergic reactions to penicillin are noted clinically immediate and delayed.

Immediate reactions usually occur within 20 minutes of administration and range in severity from urticaria and pruritus to angioneurotic edema, iaryngospasm, bronchospasm, hypotension, vascular collapse and death. Such immediate anaphylatic reactions are very rare (see WARNINGS) and usually occur after parenteral therapy, but have occurred in patients receiving oral therapy. Another type of immediate reaction, an accelerated reaction, may occur between 20 minutes and 48 hours after administration and may include urticaria, pruritus and fever. Although Iaryngeal edema, laryngospasm and hypotension occasionally occur, fatality is uncommon.

Delayed allergic reactions to penicillin therapy usually occur after 48 hours and sometimes as late as two to four weeks after initiation of therapy. Manifestations of this type of reaction include serum sickness-like symptoms (ie, fever, malaise, urticarii, myalgia, arthralgia, abdominal pain) and various skin rashes. Nausea. vomiting, diarrhea, stomatitis, black or harry tongue and other symptoms of gastrointestinal irritation may occur, especially during oral penicillin therapy .

Nervous System REACTIONS

Neurotoxic reactions similar to those observed with penicillin G may occur with large intravenous doses of the peniciilinase-resistant penicillins, especially with patients with renal insufficiency.

Urogenital REACTIONS

Renal tubular damage and interstitial nephritis have been associated with the administration of methicin sodium and infrequently, with the administration of nafcillin and oxacillin. Manifestations of this reacti on may include rash, fever, eosinophilia, hematuria, proteinuria and renal insufficiency. Methicillin-induced nephropathy does not appear to be dose-related and is generally reversible upon prompt discontinuation of therapy.

Metabolic REACTIONS

Agranulocytosis, neutropenia and bone marrow depression have been associated with the use of methicin sodium and nafcillin.

Hepatotoxicity, characterized by fever, nausea and vomiting associated with abnormal liver function tests, mainly elevated SGOT levels, has been associated with the use of oxacillin.

RECOMENDED DOSAGES FOR DICLOXACILLIN IN MILD TO MODERATE AND SEVERE INFECTIONS
DRUG ADULTS CHILDREN
Mild to Moderate Severe Mild to Moderate Severe
Dicloxacillin 125 mg every 6 hours 250 mg every 6 hours 12.5 mg/kg/dayb in equally divided doses every 6 hours 25 mg/kg/dayb in equally divided doses every 6 hours
b Patients weighing less than 40 kg (88 Ibs.)

Read the Dynapen (dicloxacillin) Side Effects Center for a complete guide to possible side effects »

DRUG INTERACTIONS

Tetracycline, a bacteriostatic antibiotic, may antagonize the bactercidal effect of penicillin and concurrent use of these drugs should be avoided.

Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.

Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

WARNINGS

Serious and occasionally fatal hypersensitivity (anaphylactic shock with collapse) reactions have occurred in patients receiving penicillin. The incidence of anaphylactic shock in all penicillin-treated patients is between 0.015% and 0.04%. Anaphylactic shock resulting in death has occurred in approximately 0.002% of the patients treated. Although anaphylaxis is more frequent following a parenteral administration, it has occurred in patients receiving oral penicillins.

When penicillin therapy is indicated, it should be initiated only after a comprehensive patient drug and allergy history has been obtained. If an allergic reaction occurs, the drug should be discontinued and the patient should receive supportive treatment, eg, artificial maintenance of ventilation, pressor amines, antihistamines and corticosteroids. Individuals with a history of penicillin hypersensitivity may also experience allergic reactions when treated with a cephalosporin.

PRECAUTIONS

General

Dicloxacillin should generally not be administered to patients with a history of sensitivity to any penicillin.

Penicillin should be used with caution in individuals with histories of significant allergies and/or asthma. Whenever allergic reactions occur, penicillin should be withdrawn unless, in the opinion of the physician, the condition being treated is life-threatening and amenable only to penicillin therapy.

The oral route of administration should not be relied upon in patients with severe illness, or with nausea, vomiting, gastric dilatation, cardiospasm or intestinal hypermotility. Occasionally, patients will not absorb therapeutic amounts of orally administered penicillin. The use of antibiotics may result in overgrowth of nonsusceptible organisms. If new infections due to bacteria or fungi occur, the drug should be discontinued and appropriate measures taken.

Information for the Patient

See PATIENT INFORMATION section.

Laboratory Tests

Bacteriologic studies to determine the causative organisms and their susceptibility to the penicillinase- resistant penicillins should be performed (see CLINICAL PHARMACOLOGY - Microbiology). In the treatment of suspected staphylococcnl infections therapy should be changed to another active agent if culture tests fail to demonstrate the presence of staphylococci.

Periodic assessment of organ system function, including renal, hepatic and hematopoietic should be made during prolonged therapy with the penicillinase-resistant penicillins.

Blood cultures white blood cell and differential cell counts should be obtained prior to initiation of therapy and at least weekly during therapy with pencillinase-resistant penicillins.

Periodic urinalysis blood urea nitrogen and creatinine determinations should be performed during therapy with the penicillinase-resistant penicillins and dosage alterations should be considered if these values become elevated It any impairment of renal function is suspected or known to exist a reduction in the total dosage should be considered and blood levels monitored to avoid possible neurotoxin reactions (see DOSAGE AND ADMINISTRATION).

SGOT and SGPT values should be obtained periodically during therapy to monitor tor possible liver function abnormalities.

Drug Interactions

Tetracycline. a bacteriostatic antibiotic may antagonize the bacterci dal effect of penicillin and concurrent use of these drugs should be avoided.

Carcinogenesis, Mutagenesis, Impairment of Fertility

No long-term animal studies have been conducted with these drugs

Studies on reproduction (nafcillin) in rats and rabbits reveal no fetal or maternal abnormalities before conception and continuously through weaning (one generation).

Pregnancy Category B

Reproduction studies performed in the mouse, rat and rabbit have revealed no evidence of impaired fertility or harm to the fetus due to the pencillinase-resistant pencillins. Human experience with the penicillins during pregnancy has not shown any postive evidence of adverse effects on the fetus. There are however, no adequate or well-controlled studies in pregnant women showing conclusively that harmful effects of these drugs on the fetus can be excluded. Because animal reproduction studies are not always predictive of human response this drug should be used during pregnancy only if clearly needed.

Nursing Mothers

Penicillins are excreted in breast milk. Caution should be exercised when penicillins are administered to a nursing woman.

Pediatric Use

Because of incompletely developed renal function in newborns, penicillinase-resistant penicillins (especially methicillin) may not be completely excreted, with abnormally high blood levels resulting. Frequent monitoring of blood levels is advisable in this group, with dosage adjustments when necessary. All newborns treated with penicillins should be monitored cioselv for clinical and laboratory evidence of toxic or Adverse effects (see DOSAGE AND ADMINISTRATION).

Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.

Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

OVERDOSE

No information provided.

CONTRAINDICATIONS

A history of a hypersensitivity (anaphylactic) reaction to any penicillin is a contraindication.

Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.

Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

CLINICAL PHARMACOLOGY

Microbiology

Dicloxacillin exerts a bactericidal action against penicillin-susceptible microorganisms during the state of active multiplication. All penicillins inhibit the biosynthesis of the bacterial cell wall.

The drugs in this class are highly resistant to inactivation by staphylococcal penicillinase and are active against penicillinase-producing and non-penicillinase-producing strains of Staphylococcus aureus. The penicillinase-resistant penicillins are active in vitro against a variety of other bacteria.

Susceptibility Plate Testing

Quantitative methods of susceptibility testing that require measurements of zone diameters or minimal inhibitory concentrations (MICs) give the most precise estimates of antibiotic susceptibility. One such procedure has been recommended for use with discs to test susceptibility to this class of drugs. Interpretations correlate diameters on the disc test with MIC values.

A penicillinase-resistant class disc may be used to determine microbial susceptibility to dicloxacillin.

TABLE I shows the interpretation of test results for penicillinase-resistant penicillins using the FDA Standard Disc Test Method (formerly Bauer-Kirby-Sherris-Turck method) of disc bacteriological susceptibility testing for staphylococci with a disc containing 5 micrograms of methicillin sodium.

With this procedure, a report from a laboratory of "susceptible" indicates that the infecting organism is likely to respond to therapy. A report of "resistant" indicates that the infecting organism is not likety to respond to therapy. A report of "intermediate" susceptibility suggests that the organism might be susceptible if high doses of the antibiotic are used, or if the infection is confined to tissues and fluids (eg, urine) in which high antibiotic levels are attained.

In general, all staphylococci should be tested against the penicillin G disc and against the methicillin disc. Routine methods of antibiotic susceptibility testing may fail to detect strains of organisms resistant to the penicillinase-resistant penicillins. For this reason, the use of large inocula and 48-hour incubation periods may be necessary to obtain accurate susceptibility studies with these antibiotics. Bacterial strains which are resistant to one of the penicillinase-resistant penicillins should be considered resistant to all of the drugs in the class.

Table 1.

Standardized Disc T.S. Method Of Bacteriological Susceptibility Testing Using a Class Disc Containing 5 Micrograms Of Methicillin Sodium
Diameters of Zone
Indicating "Susceptible"
at least 14mm
Diameters of Zone
Indicating "Intermediate"
10 - 13mm
Diameters of Zone
Indicating "Resistant"
less than 10mm

Pharmacokinetics

Methicillin sodium is readily destroyed by gastric acidity and must be administered by intramuscular or intravenous injection. The isoxazolyl penicillins (cloxacillin, dicloxacillin and oxacillin) and nafciliin are more acid-resistant and may be administered orally.

Absorption of the isoxazolyl penicillins after oral administration is rapid but incomplete: peak blood levels are achieved in 1-1.5 hours. In one study, after ingestion of a single 500 mg oral dose, peak serum concentrations range from 5-7 micrograms/milliliter for oxacillin, from 7.5- 14.4 mg/ mL for cloxacillin and from 10-17 mg/mL for dicloxacillin.

Oral absorption of cloxacillin, dicloxacillin, oxacillin and nafcillin is delayed when the drugs are administered after meals.

Once absorbed, the penicillinase-resistant penicillins bind to serum protein, mainly albumin. The degree of protein binding reported varies with the method of study and the investigator (see TABLE 2).

Table 2.

Penicillinase-Resistant Penicillins Percent Protein Binding ± SD
Methicillin 37.3 ± 7.9
Nafcillin 89.9 ± 1.5
Oxacillin 94.2 ± 2.1
Cloxacillin 95.2 ± 0.5
Dicloxacillin 97.9 ± 0.6

The penicillinase-resistant penicillins vary in the extent to which they are distributed in the body fluids. With normal doses, insignificant concentrations are found in the cerebrospinal fluid and aqueous humor. All the drugs in this class are found in therapeutic concentrations in the pleural, bile and amniotic fluids.

The penicillinase-resistant penicillins are rapidly excreted, primarily as unchanged drug in the urine by glomerular filtration and active tubular secretion The elimination half-life for dicloxacillin is about 0.7 hour. Nonrenal elimination includes hepatic inactivation and excretion in bile.

Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.

Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

PATIENT INFORMATION

Patients receiving penicillins should be given the following information and instructions by the physician:

1. Patients should be told that penicillin is an antibacterial agent which will work with the body's natural defenses to control certain types of infections. They should be told that the drug should not be taken if they have had an allergic reaction to any form of penicillin previously, and to inform the physician of any allergies or previous allergic reactions to any drugs they may have had (see WARNINGS).

2. Patients who have previously experienced an anaphylactic reaction to penicillin should be instructed to wear a medical identification tag or bracelet.

3. Because most antibacterial drugs taken by mouth are best absorbed on an empty stomach, patients should be directed, unless circumstances warrant otherwise, to take penicillin one hour before meals or two hours after eating (see CLINICAL PHARMACOLOGY: Pharmacokinetics).

4. Patients should be told to take the entire course of therapy prescribed. even if fever and other symptoms have stopped (see PRECAUTIONS - General).

5. If any of the following reactions occur stop taking your prescription and notify the physiclan shortness of breath wheezing, skin rash, mouth irritation, black tongue, sore throat, nausea, vomiting, diarrhea, fever, swollen joints or any unusual bleeding or bruising (see ADVERSE REACTIONS).

6. Do not take any additional medications without physician approval including nonprescription drugs such as antacids laxatives or vitamins.

7. Discard any liquid forms of penicillin after seven days if stored at room temperature or after 14 days it refrigerated.

Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.

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Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

PATIENT INFORMATION

Patients receiving penicillins should be given the following information and instructions by the physician:

1. Patients should be told that penicillin is an antibacterial agent which will work with the body's natural defenses to control certain types of infections. They should be told that the drug should not be taken if they have had an allergic reaction to any form of penicillin previously, and to inform the physician of any allergies or previous allergic reactions to any drugs they may have had (see WARNINGS).

2. Patients who have previously experienced an anaphylactic reaction to penicillin should be instructed to wear a medical identification tag or bracelet.

3. Because most antibacterial drugs taken by mouth are best absorbed on an empty stomach, patients should be directed, unless circumstances warrant otherwise, to take penicillin one hour before meals or two hours after eating (see CLINICAL PHARMACOLOGY: Pharmacokinetics).

4. Patients should be told to take the entire course of therapy prescribed. even if fever and other symptoms have stopped (see PRECAUTIONS - General).

5. If any of the following reactions occur stop taking your prescription and notify the physiclan shortness of breath wheezing, skin rash, mouth irritation, black tongue, sore throat, nausea, vomiting, diarrhea, fever, swollen joints or any unusual bleeding or bruising (see ADVERSE REACTIONS).

6. Do not take any additional medications without physician approval including nonprescription drugs such as antacids laxatives or vitamins.

7. Discard any liquid forms of penicillin after seven days if stored at room temperature or after 14 days it refrigerated.

Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.

Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Dynapen
(dicloxacillin sodium)

DRUG DESCRIPTION

Dicloxacillin sodium is a semisynthetic antibiotic substance which resists destruction by the enzyme penicillinase (beta-lactamase). It is monosodium (2S,5R,6R)-6-(3-(2,6-dichlorophenyl)5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-OXO-4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylate monohydrate.

Dicloxacillin is administered orally via capsule form or powder for reconstitution.

Inactive Ingredients: Capsules: Magnesium Stearate.

  • Capsule Shell and print Constituents:
  • D& C Yellow #10 Aluminum Lake,
  • FD& C Blue #l Aluminum Lake,
  • FD& C Blue #2 Aluminum Lake,
  • FD& C Red #40 Aluminum Lake,
  • Gelatin, Pharmaceutical Glaze, Silicon Dioxide, Sodium Lauryl Sulfate, Synthetic Black Iron Oxide, Tiinium Dioxide and may contain Carboxymethylcellulose Sodium and/or Propylene Glycol.

Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.

Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Dynapen
(dicloxacillin sodium)

DRUG DESCRIPTION

Dicloxacillin sodium is a semisynthetic antibiotic substance which resists destruction by the enzyme penicillinase (beta-lactamase). It is monosodium (2S,5R,6R)-6-(3-(2,6-dichlorophenyl)5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-OXO-4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylate monohydrate.

Dicloxacillin is administered orally via capsule form or powder for reconstitution.

Inactive Ingredients: Capsules: Magnesium Stearate.

  • Capsule Shell and print Constituents:
  • D& C Yellow #10 Aluminum Lake,
  • FD& C Blue #l Aluminum Lake,
  • FD& C Blue #2 Aluminum Lake,
  • FD& C Red #40 Aluminum Lake,
  • Gelatin, Pharmaceutical Glaze, Silicon Dioxide, Sodium Lauryl Sulfate, Synthetic Black Iron Oxide, Tiinium Dioxide and may contain Carboxymethylcellulose Sodium and/or Propylene Glycol.

Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.

Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Dynapen
(dicloxacillin sodium)

DRUG DESCRIPTION

Dicloxacillin sodium is a semisynthetic antibiotic substance which resists destruction by the enzyme penicillinase (beta-lactamase). It is monosodium (2S,5R,6R)-6-(3-(2,6-dichlorophenyl)5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-OXO-4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylate monohydrate.

Dicloxacillin is administered orally via capsule form or powder for reconstitution.

Inactive Ingredients: Capsules: Magnesium Stearate.

  • Capsule Shell and print Constituents:
  • D& C Yellow #10 Aluminum Lake,
  • FD& C Blue #l Aluminum Lake,
  • FD& C Blue #2 Aluminum Lake,
  • FD& C Red #40 Aluminum Lake,
  • Gelatin, Pharmaceutical Glaze, Silicon Dioxide, Sodium Lauryl Sulfate, Synthetic Black Iron Oxide, Tiinium Dioxide and may contain Carboxymethylcellulose Sodium and/or Propylene Glycol.

Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.

Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Dynapen Patient Information Including Side Effects

Brand Names: Dycill, Dynapen

Generic Name: dicloxacillin (Pronunciation: dye klox a SIL in)

What is dicloxacillin (Dynapen)?

Dicloxacillin is an antibiotic in the penicillin group of drugs. It fights bacteria in your body.

Dicloxacillin is used to treat many different types of infections caused by bacteria such as bronchitis, pneumonia, or staphylococcal (also called "staph") infections.

Dicloxacillin may also be used for other purposes not listed in this medication guide.

Dicloxacillin 250 mg-APH

turquoise, imprinted with SQUIBB W048

Dicloxacillin 250 mg-TEV

green, imprinted with 93 3123

Dicloxacillin 500 mg-APH

turquoise, imprinted with SQUIBB W058

Dicloxacillin 500 mg-TEV

green, imprinted with 93 3125

What are the possible side effects of dicloxacillin (Dynapen)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • diarrhea that is watery or bloody;
  • fever, chills, body aches, flu symptoms;
  • easy bruising or bleeding, unusual weakness;
  • urinating less than usual or not at all;
  • severe skin rash, itching, or peeling;
  • agitation, confusion, unusual thoughts or behavior; or
  • seizure (black-out or convulsions).

Less serious side effects may include:

  • nausea, vomiting, stomach pain;
  • vaginal itching or discharge;
  • headache;
  • swollen, black, or "hairy" tongue; or
  • thrush (white patches or inside your mouth or throat).

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Read the Dynapen (dicloxacillin) Side Effects Center for a complete guide to possible side effects »

What is the most important information I should know about dicloxacillin (Dynapen)?

Do not use this medication if you are allergic to dicloxacillin or to any other penicillin antibiotic, such as amoxicillin (Amoxil), ampicillin (Omnipen, Principen), carbenicillin (Geocillin), oxacillin (Bactocill), penicillin (Beepen-VK, Ledercillin VK, Pen-V, Pen-Vee K, Pfizerpen, V-Cillin K, Veetids), and others.

Before using dicloxacillin, tell your doctor if you are allergic to cephalosporins such as Ceclor, Ceftin, Duricef, Keflex, and others, or if you have asthma, liver disease, kidney disease, or a history of any type of allergy.

Dicloxacillin can make birth control pills less effective, which may result in pregnancy. Before taking dicloxacillin, tell your doctor if you use birth control pills.

Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Dicloxacillin will not treat a viral infection such as the common cold or flu.

Do not share this medication with another person, even if they have the same symptoms you have.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Side Effects Centers

Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Dynapen Patient Information including How Should I Take

What should I discuss with my healthcare provider before taking dicloxacillin (Dynapen)?

Do not use this medication if you are allergic to dicloxacillin or to any other penicillin antibiotic, such as:

  • amoxicillin (Amoxil, Amoxicot, Biomox, Dispermox, Trimox);
  • ampicillin (Omnipen, Principen);
  • carbenicillin (Geocillin);
  • oxacillin (Bactocill); or
  • penicillin (Beepen-VK, Ledercillin VK, Pen-V, Pen-Vee K, Pfizerpen, V-Cillin K, Veetids, and others).

Before using dicloxacillin, tell your doctor if you are allergic to any drugs (especially cephalosporins such as Ceclor, Ceftin, Duricef, Keflex, and others), or if you have:

  • asthma;
  • liver disease;
  • kidney disease;
  • a bleeding or blood clotting disorder;
  • a history of diarrhea caused by taking antibiotics; or
  • a history of any type of allergy.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take dicloxacillin.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Dicloxacillin can make birth control pills less effective, which may result in pregnancy. Before taking dicloxacillin, tell your doctor if you use birth control pills.

Dicloxacillin can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take dicloxacillin (Dynapen)?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Take the medicine with a full glass of water.

Dicloxacillin should be taken on an empty stomach, at least 1 hour before or 2 hours after eating a meal.

To be sure this medication is helping your condition, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled visits to your doctor.

Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Dicloxacillin will not treat a viral infection such as the common cold or flu.

Do not share this medication with another person, even if they have the same symptoms you have.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using dicloxacillin.

Store dicloxacillin at room temperature away from moisture, heat, and light.

Side Effects Centers

Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Dynapen Patient Information including If I Miss a Dose

What happens if I miss a dose (Dynapen)?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose (Dynapen)?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include confusion, behavior changes, a severe skin rash, urinating less than usual, or seizure (black-out or convulsions).

What should I avoid while taking dicloxacillin (Dynapen)?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

What other drugs will affect dicloxacillin (Dynapen)?

Before taking dicloxacillin, tell your doctor if you are using any of the following drugs:

  • methotrexate (Rheumatrex, Trexall); or
  • probenecid (Benemid).

This list is not complete and there may be other drugs that can interact with dicloxacillin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about dicloxacillin.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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