Dyphylline (Lufyllin)
برای این دارو، اطلاعات عمومی (فارسی) یافت نشد . برای افزودن اطلاعات فارسی به این دارو کلیک نمایید.
Dyphylline (Lufyllin)

DRUG DESCRIPTION

LUFYLLIN (dyphylline), a xanthine derivative, is a bronchodilator available for oral administration as tablets containing 200 mg and 400 mg of dyphylline. Other ingredients: magnesium stearate, microcrystalline cellulose.

Chemically, dyphylline is 7-(2,3-dihydroxypropyl)-theophylline, a white, extremely bitter, amorphous powder that is freely soluble in water and soluble in alcohol to the extent of 2 g/100 mL. Dyphylline forms a neutral solution that is stable in gastrointestinal fluids over a wide range of pH.

The molecular formula for dyphylline is C 10 H 14 N 4 O 4 with a molecular weight of 254.25. The structual formula is:

What are the possible side effects of dyphylline (Dilor, Dylix, Lufyllin, Neothylline)?

If you experience any of the following serious side effects, stop taking dyphylline and seek emergency medical attention:

  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
  • seizures;
  • increased or irregular heartbeats; or
  • severe nausea or vomiting.

Other, less serious side effects may occur although they are not common at appropriate doses. Continue to take dyphylline and talk to your doctor if you experience

  • slight nausea, decreased...

Read All Potential Side Effects and See Pictures of Lufyllin »

What are the precautions when taking dyphylline (Lufyllin)?

Before using dyphylline, tell your doctor or pharmacist if you are allergic to it; or to theophylline, theobromine or caffeine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: glaucoma, diabetes, heart problems (e.g., angina, irregular heartbeat), high blood pressure, kidney disease, seizures, stomach/intestinal ulcer, overactive thyroid (hyperthyroidism).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic...

Read All Potential Precautions of Lufyllin »

Last reviewed on RxList: 1/20/2005
This monograph has been modified to include the generic and brand name in many instances.

INDICATIONS

For relief of acute bronchial asthma and for reversible bronchospasm associated with chronic bronchitis and emphysema.

DOSAGE AND ADMINISTRATION

Dosage should be individually titrated according to the severity of the condition and the response of the patient.

Usual adult dosage:   Up to 15 mg/kg every six hours.

Appropriate dosage adjustments should be made in patients with impaired renal function (see Clinical PHARMACOLOGY ).

HOW SUPPLIED

LUFYLLIN Tablets contain 200 mg dyphylline and are white, rectangular, scored on one side and imprinted WALLACE 521 on the other side. The tablets are available in bottles of 100 (NDC 0037-0521-92), 1000 (NDC 0037-0521-97), and 5000 (NDC 0037-0521-98).

LUFYLLIN-400 Tablets contain 400 mg dyphylline and are white, capsule-shaped, scored on one side and imprinted WALLACE 731 on the other side. The tablets are available in bottles of 100 (NDC 0037-0731-92), 1000 (NDC 0037-0731-97), and 2500 (NDC 0037-0731-99).

Storage:   Store at controlled room temperature 20°-25°C (68°-77°F).

Dispense in a tight container.

WALLACE LABORATORIES
Division of
Carter-Wallace, Inc.
Cranbury, New Jersey 08512

Last reviewed on RxList: 1/20/2005
This monograph has been modified to include the generic and brand name in many instances.

SIDE EFFECTS

Adverse reactions with the use of LUFYLLIN (dyphylline) have been infrequent, relatively mild, and rarely required reduction in dosage or withdrawal of therapy.

The following adverse reactions which have been reported with other xanthine bronchodilators, and which have most often been related to excessive drug plasma levels, should be considered as potential adverse effects when dyphylline is administered:

Gastrointestinal:   nausea, vomiting, epigastric pain, hematemesis, diarrhea.

Central nervous system:   headache, irritability, restlessness, insomnia, hyperexcitability, agitation, muscle twitching, generalized clonic and tonic convulsions.

Cardiovascular:   palpitation, tachycardia, extrasystoles, flushing, hypotension, circulatory failure, ventricular arrhythmias.

Respiratory:   tachypnea.

Renal:   albuminuria, gross and microscopic hematuria, diuresis.

Other:   hyperglycemia, inappropriate ADH syndrome.

Read the Lufyllin (dyphylline) Side Effects Center for a complete guide to possible side effects »

DRUG INTERACTIONS

Synergism between xanthine bronchodilators (e.g., theophylline), ephedrine, and other sympathomimetic bronchodilators has been reported. This should be considered whenever these agents are prescribed concomitantly.

Concurrent administration of dyphylline and probenecid, which competes for tubular secretion, has been shown to increase the plasma half-life of dyphylline (see Clinical PHARMACOLOGY ).

Last reviewed on RxList: 1/20/2005
This monograph has been modified to include the generic and brand name in many instances.

WARNINGS

LUFYLLIN (dyphylline) is not indicated in the management of status asthmaticus, which is a serious medical emergency.

Although the relationship between plasma levels of dyphylline and appearance of toxicity is unknown, excessive doses may be expected to be associated with an increased risk of adverse effects.

PRECAUTIONS

General:   Use LUFYLLIN (dyphylline) with caution in patients with severe cardiac disease, hypertension, hyperthyroidism, acute myocardial injury, or peptic ulcer.

Carcinogenesis, mutagenesis, impairment of fertility:   No long-term animal studies have been performed with LUFYLLIN (dyphylline) .

Pregnancy:   Teratogenic effects Pregnancy Category C. Animal reproduction studies have not been conducted with LUFYLLIN (dyphylline) . It is also not known if LUFYLLIN (dyphylline) can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. LUFYLLIN (dyphylline) should be given to a pregnant woman only if clearly needed.

Nursing mothers:   Dyphylline is present in human milk at approximately twice the maternal plasma concentration. Caution should be exercised when LUFYLLIN (dyphylline) is administered to a nursing woman.

Pediatric use:   Safety and effectiveness in children have not been established.

Geriatric Use: Clinical studies of LUFYLLIN (dyphylline) did not include sufficient numbers of subjects age 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy

Last reviewed on RxList: 1/20/2005
This monograph has been modified to include the generic and brand name in many instances.

OVERDOSE

There have been no reports, in the literature, of overdosage with LUFYLLIN (dyphylline) . However, the following information based on reports of theophylline overdosage are considered typical of the xanthine class of drugs and should be kept in mind.

Signs and symptoms:   Restlessness, anorexia, nausea, vomiting, diarrhea, insomnia, irritability, and headache. Marked overdosage with resulting severe toxicity has produced agitation, severe vomiting, dehydration, excessive thirst, tinnitus, cardiac arrhythmias, hyperthermia, diaphoresis, and generalized clonic and tonic convulsions. Cardiovascular collapse has also occurred, with some fatalities. Seizures have occurred in some cases associated with very high theophylline plasma concentrations, without any premonitory symptoms of toxicity.

Treatment:   There is no specific antidote for overdosage with drugs of the xanthine class. Symptomatic treatment and general supportive measures should be instituted with careful monitoring and maintenance of vital signs, fluids, and electrolytes. The stomach should be emptied by inducing emesis if the patient is conscious and responsive, or by gastric lavage, taking care to protect against aspiration, especially in stuporous or comatose patients. Maintenance of an adequate airway is essential in case oxygen or assisted respiration is needed. Sympathomimetic agents should be avoided but sedatives such as short-acting barbiturates may be useful.

Dyphylline is dialyzable and, although not recommended as a routine procedure in overdosage cases, hemodialysis may be of some benefit when severe intoxication is present or when the patient has not responded to general supportive and symptomatic treatment.

CONTRAINDICATIONS

Hypersensitivity to dyphylline or related xanthine compounds.

Last reviewed on RxList: 1/20/2005
This monograph has been modified to include the generic and brand name in many instances.

CLINICAL PHARMACOLOGY

Dyphylline is a xanthine derivative with pharmacologic actions similar to theophylline and other members of this class of drugs. Its primary action is that of bronchodilation, but it also exhibits peripheral vasodilatory and other smooth muscle relaxant activity to a lesser degree. The bronchodilatory action of dyphylline, as with other xanthines, is thought to be mediated through competitive inhibition of phosphodiesterase with a resulting increase in cyclic AMP producing relaxation of bronchial smooth muscle.

LUFYLLIN (dyphylline) is well tolerated and produces less nausea than aminophylline and other alkaline theophylline compounds when administered orally. Unlike the hydrolyzable salts of theophylline, dyphylline is not converted to free theophylline in vivo. It is absorbed rapidly in therapeutically active form and in healthy volunteers reaches a mean peak plasma concentration of 17.1 mcg/mL in approximately 45 minutes following a single oral dose of 1000 mg of LUFYLLIN.

Dyphylline exerts its bronchodilatory effects directly and, unlike theophylline, is excreted unchanged by the kidneys without being metabolized by the liver. Because of this, dyphylline pharmacokinetics and plasma levels are not influenced by various factors that affect liver function and hepatic enzyme activity, such as smoking, age, congestive heart failure, or concomitant use of drugs which affect liver function.

The elimination half-life of dyphylline is approximately two hours (1.8-2.1 hr) and approximately 88% of a single oral dose can be recovered from the urine unchanged. The renal clearance would be correspondingly reduced in patients with impaired renal function. In anuric patients, the half-life may be increased 3 to 4 times normal.

Dyphylline plasma levels are dose-related and generally predictable. The range of plasma levels within which dyphylline can be expected to produce effective bronchodilation has not been determined.

Dyphylline plasma concentrations can be accurately determined using high pressure liquid chromatography (HPLC) * or gas-liquid chromatography (GLC).


* See Valia, et al., J. Chromatogr. 221 : 170 (1980). Small quantities of pure dyphylline powder may be obtained from Wallace Laboratories, Cranbury, N.J. The internal standard, (beta)-hydroxyethyl-theophylline, may be obtained from companies supplying analytical chemicals.

 

Last reviewed on RxList: 1/20/2005
This monograph has been modified to include the generic and brand name in many instances.

PATIENT INFORMATION

No Information Provided.

See WARNINGS and PRECAUTIONS sections

Last reviewed on RxList: 1/20/2005
This monograph has been modified to include the generic and brand name in many instances.

>

PATIENT INFORMATION

No Information Provided.

See WARNINGS and PRECAUTIONS sections

Last reviewed on RxList: 1/20/2005
This monograph has been modified to include the generic and brand name in many instances.

Disclaimer

Lufyllin Consumer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

DYPHYLLINE - ORAL

(DYE-fi-lin)

COMMON BRAND NAME(S): Dilor, Lufyllin

USES: This medication is used to treat and prevent wheezing and trouble breathing caused by ongoing lung disease (e.g., asthma, emphysema, chronic bronchitis). Dyphylline belongs to a class of drugs known as xanthines. It works in the airways by relaxing muscles, opening air passages to improve breathing, and decreasing the lungs' response to irritants. Controlling symptoms of breathing problems can decrease time lost from work or school.

HOW TO USE: Take this medication by mouth with or without food, usually 4 times daily or as directed by your doctor. If this medication upsets your stomach, you may take it with food.

If you are taking a liquid form, use a medication-measuring device to carefully measure the prescribed dose. Do not use a household spoon.

If you are taking a tablet scored with a line, you may break it before swallowing.

Dosage is based on your medical condition and response to therapy.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

Inform your doctor if your condition persists or worsens.

Disclaimer

Lufyllin Consumer (continued)

SIDE EFFECTS: Stomach pain/cramping, nausea, vomiting, diarrhea, loss of appetite, headache, trouble sleeping, irritability, restlessness, nervousness, shaking, flushing, and increased urination may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: confusion, dizziness, mental/mood changes, muscle twitching/pain/tenderness, weakness, rapid breathing.

Tell your doctor immediately if any of these rare but very serious side effects occur: fainting, fast/slow/irregular heartbeat, vomit that looks like coffee grounds, dark/tarry stools, blood in urine, seizures.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, red/scaly skin, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the Lufyllin (dyphylline) Side Effects Center for a complete guide to possible side effects »

PRECAUTIONS: Before using dyphylline, tell your doctor or pharmacist if you are allergic to it; or to theophylline, theobromine or caffeine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: glaucoma, diabetes, heart problems (e.g., angina, irregular heartbeat), high blood pressure, kidney disease, seizures, stomach/intestinal ulcer, overactive thyroid (hyperthyroidism).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Liquid preparations of this product may contain sugar and/or alcohol. Caution is advised if you have diabetes, alcohol dependence, or liver disease. Ask your doctor or pharmacist about using this product safely.

Before having surgery, tell your doctor or dentist that you are using this medication.

Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, caution is advised when using this drug in the elderly because they may be more sensitive to its effects.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This drug passes into breast milk and may have undesirable effects on a nursing infant (e.g., irritability). Consult your doctor before breast-feeding.

Disclaimer

Lufyllin Consumer (continued)

DRUG INTERACTIONS: Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: adenosine, adrenaline-like drugs (e.g., ephedrine, phenylephrine, pseudoephedrine), certain antiarrhythmic drugs (e.g., mexiletine, propafenone), benzodiazepines (e.g., diazepam, flurazepam), certain beta blockers (e.g., propranolol), digoxin, isoproterenol, lithium, probenecid.

Check the labels on all your medicines (e.g., cough-and-cold products, diet aids) because they may contain ingredients that could increase the side effects of this medication. Ask your pharmacist about using those products safely.

Caffeine and alcohol can increase the side effects of this medication. Avoid drinking large amounts of beverages containing alcohol or caffeine (e.g., coffee, tea, colas), or eating large amounts of chocolate.

This medication may interfere with certain medical/laboratory tests (e.g., dipyridamole-thallium imaging tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: agitation, nausea, frequent vomiting, trouble sleeping, unusual thirst, fever, ringing in the ears, fast/irregular heartbeat, seizures, confusion, chest pain.

NOTES: Do not share this medication with others.

MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

STORAGE: Store in a tightly closed container at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store in the bathroom. Do not freeze liquid forms of this medication. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

MEDICAL ALERT: Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-800-854-1166 (USA) or 1-800-668-1507 (Canada).

Information last revised May 2010. Copyright(c) 2010 First Databank, Inc.

Lufyllin Patient Information Including Side Effects

Brand Names: Dilor, Dylix, Lufyllin, Neothylline

Generic Name: dyphylline (Pronunciation: dye FI lin)

What is dyphylline (Lufyllin)?

Dyphylline is a bronchodilator. Dyphylline works in several ways: It relaxes muscles in your lungs and chest to allow more air in, it decreases the sensitivity of your lungs to allergens and other substances that cause inflammation, and it increases the contractions of your diaphragm to draw more air into the lungs.

Dyphylline is used to treat the symptoms of asthma, bronchitis, and emphysema.

Dyphylline may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of dyphylline (Lufyllin)?

If you experience any of the following serious side effects, stop taking dyphylline and seek emergency medical attention:

  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
  • seizures;
  • increased or irregular heartbeats; or
  • severe nausea or vomiting.

Other, less serious side effects may occur although they are not common at appropriate doses. Continue to take dyphylline and talk to your doctor if you experience

  • slight nausea, decreased appetite, or weight loss;
  • restlessness, tremor, or insomnia; or
  • headache, lightheadedness, or dizziness.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Read the Lufyllin (dyphylline) Side Effects Center for a complete guide to possible side effects »

What is the most important information I should know about dyphylline (Lufyllin)?

Call your doctor right away if you experience nausea, vomiting, insomnia, restlessness, seizures, an increased heart rate, or a headache. These could be signs of too much dyphylline in your blood.

Do not start or stop smoking without your doctor's knowledge. Smoking may affect your dosage.

Do not take more of this medicine than is prescribed without consulting your doctor. Seek medical attention if you are having increasing difficulty breathing.

Side Effects Centers

Lufyllin Patient Information including How Should I Take

Who should not take dyphylline (Lufyllin)?

Before taking this medication, tell your doctor if you have

  • a stomach ulcer;
  • seizures;
  • high blood pressure, a heart condition, or any type of heart disease;
  • fluid in your lungs;
  • a thyroid condition;
  • liver disease; or
  • kidney disease.

You may not be able to take dyphylline, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

Dyphylline is in the FDA pregnancy category C. This means that it is not known whether dyphylline will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant.

Dyphylline passes into breast milk and could affect a nursing baby. Do not take dyphylline without first talking to your doctor if you are breast-feeding a baby.

If you are over 60 years of age, you may be more likely to experience side effects from dyphylline. You may require a lower dose of this medication.

How should I take dyphylline (Lufyllin)?

Take dyphylline exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

You can take dyphylline with food to lessen stomach upset.

Take your doses at the same time every day to keep a constant level of dyphylline in your blood.

Shake the liquid forms of this medication well before use. To ensure that you get a correct dose, measure the liquid with a dose-measuring cup or spoon, not a regular tablespoon. If a spoon or cup is not provided with the medication and you do not have one, ask your pharmacist where you can get one.

Do not switch to another brand or a generic form of dyphylline without the approval of your doctor.

Store dyphylline at room temperature away from moisture and heat.

Side Effects Centers

Lufyllin Patient Information including If I Miss a Dose

What happens if I miss a dose (Lufyllin)?

Take the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take a double dose of this medication.

What happens if I overdose (Lufyllin)?

Seek emergency medical attention.

Symptoms of a dyphylline overdose include nausea, vomiting, headache, insomnia, tremor (shaking hands or twitching,), restlessness, seizures, and irregular heartbeats.

What should I avoid while taking dyphylline (Lufyllin)?

Use caution when driving, operating machinery, or performing other hazardous activities. Dyphylline may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Do not start or stop smoking without the approval of your doctor. Smoking changes the way your body uses dyphylline, and you may need a dose adjustment.

Avoid changing your dose or changing the time of your daily doses.

Do not change the brand, generic form, or formulation (tablet, capsule, liquid) of dyphylline that you are taking without the approval of your doctor. Different brands or formulations may require different dosages.

Avoid eating excessive amounts of grilled or char-broiled foods. Doing so may also change the dose of dyphylline that you need.

Avoid caffeinated beverages such as coffee, tea, and cola. Dyphylline is related chemically to caffeine, and you may experience some side effects if you consume too much caffeine.

What other drugs will affect dyphylline (Lufyllin)?

Dyphylline interacts with many other drugs. Tell your doctor and pharmacist about all other medications that you are taking, including herbal remedies, vitamins, and other nonprescription items.

The following drugs may increase the levels of dyphylline in your blood, leading to dangerous side effects:

  • alcohol;
  • cimetidine (Tagamet, Tagamet HB);
  • fluoroquinolone antibiotics such as enoxacin (Penetrex), lomefloxacin (Maxaquin), ciprofloxacin (Cipro), norfloxacin (Noroxin), and ofloxacin (Floxin);
  • clarithromycin (Biaxin) and erythromycin (Ery-Tab, E.E.S., E-Mycin, others);
  • disulfiram (Antabuse);
  • estrogens (Ogen, Premarin, and many other types);
  • fluvoxamine (Luvox);
  • methotrexate (Folex, Rheumatrex);
  • mexiletine (Mexitil) and propafenone (Rythmol);
  • propranolol (Inderal);
  • tacrine (Cognex);
  • ticlopidine (Ticlid); and
  • verapamil (Verelan, Calan, Isoptin).

The following drugs may decrease dyphylline levels in your blood, leading to poor asthma control:

  • aminoglutethimide (Cytadren),
  • carbamazepine (Tegretol),
  • isoproterenol (Isuprel),
  • moricizine (Ethmozine),
  • phenobarbital (Luminal, Solfoton),
  • phenytoin (Dilantin),
  • rifampin (Rifadin), and
  • sucralfate (Carafate).

Drugs other than those listed here may also interact with dyphylline or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

Your pharmacist has additional information about dyphylline written for health professionals that you may read.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 2.05. Revision date: 12/15/2010.

Your use of the content provided in this service indicates that you have read,understood and agree to the End-User License Agreement,which can be accessed by clicking on this link.

Healthwise

Side Effects Centers

توزیع کنندگان این دارو
شرکت های تولید کننده یا وارد کننده دارو

دارونـــما
نوآوری برای سلامت

طراحی و اجرا M.Ramezani
ارتباط با ما Info@darunama.com