Ertaczo (Sertaconazole Nitrate)
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Ertaczo (Sertaconazole Nitrate)

ERTACZO®
(sertaconazole nitrate) Cream, 2%.

For Topical Dermatologic Use Only - Not for Oral, Ophthalmic or Intravaginal Use

DRUG DESCRIPTION

ERTACZO® (sertaconazole nitrate) Cream, 2%, contains the imidazole antifungal, sertaconazole nitrate. Sertaconazole nitrate contains one asymmetric carbon atom and exists as a racemic mixture of equal amounts of R and S enantiomers.

Sertaconazole nitrate is designated chemically as (±)-1-[2,4-dichloro-β-[(7-chlorobenzo-[b]thien-3-yl)methoxy]phenethyl]imidazole nitrate. It has a molecular weight of 500.8. The molecular formula is C20H15Cl3N2OS• HNO3, and the structural formula is as follows:

ERTACZO® (sertaconazole nitrate)   Structural Formula Illustration

Sertaconazole nitrate is a white or almost white powder. It is practically insoluble in water, sol-uble in methanol, sparingly soluble in alcohol and in methylene chloride. Each gram of ERTACZO® (sertaconazole nitrate) Cream, 2%, contains 17.5 mg of sertaconazole (as sertaconazole nitrate, 20 mg) in a white cream base of ethylene glycol and polyethylene glycol palmitostearate, glyceryl isostearate, light mineral oil, methylparaben, polyoxyethylened saturated glycerides and glycol-ized saturated glycerides, sorbic acid and purified water.

What are the possible side effects of sertaconazole topical (Ertaczo)?

Serious side effects are not expected to occur with the use of sertaconazole topical. Stop using sertaconazole topical and contact your doctor if you experience unusual or severe itching, redness, burning, blistering, swelling, oozing, or irritation of the skin.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at...

Read All Potential Side Effects and See Pictures of Ertaczo »

What are the precautions when taking sertaconazole nitrate (Ertaczo)?

Before using sertaconazole, tell your doctor or pharmacist if you are allergic to it; or to other azole antifungals such as clotrimazole, ketoconazole, or miconazole; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before...

Read All Potential Precautions of Ertaczo »

Last reviewed on RxList: 12/29/2008
This monograph has been modified to include the generic and brand name in many instances.

INDICATIONS

ERTACZO® (sertaconazole nitrate) Cream, 2%, is indicated for the topical treatment of interdigital tinea pedis in immunocompetent patients 12 years of age and older, caused by: Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum (see Clinical Studies Section).

DOSAGE AND ADMINISTRATION

In the treatment of interdigital tinea pedis, ERTACZO® (sertaconazole nitrate) Cream, 2%, should be applied twice daily for 4 weeks. Sufficient ERTACZO® (sertaconazole nitrate) Cream, 2%, should be applied to cover both the affected areas between the toes and the immediately surrounding healthy skin of patients with interdig-ital tinea pedis. If a patient shows no clinical improvement 2 weeks after the treatment period, the diagnosis should be reviewed.

HOW SUPPLIED

ERTACZO® (sertaconazole nitrate) Cream, 2%, is supplied in tubes in the following sizes:

30-gram tube NDC 0062-1650-03
60-gram tube NDC 0062-1650-02

Store at 25°C (77°F); excursions permitted to 15°-30°C (59°-86°F) [see USP Controlled Room Temperature].

Distributed By: OrthoNeutrogena, Division Of Ortho-Mcneil Pharmaceutical, Inc. Los Angeles, CA 90045. Revised November 2005. FDA revision date: 11/22/2005

Last reviewed on RxList: 12/29/2008
This monograph has been modified to include the generic and brand name in many instances.

SIDE EFFECTS

In clinical trials, cutaneous adverse events occurred in 7 of 297 (2%) patients (2 of them severe) receiving ERTACZO® (sertaconazole nitrate) Cream, 2%, and in 7 of 291 (2%) patients (2 of them severe) receiving vehicle. These reported cutaneous adverse events included contact dermatitis, dry skin, burning skin, application site reaction and skin tenderness.

In a dermal sensitization study, 8 of 202 evaluable patients tested with ERTACZO® (sertaconazole nitrate) Cream, 2%, and 4 of 202 evaluable patients tested with vehicle, exhibited a slight erythematous reaction in the challenge phase. There was no evidence of cumulative irritation or contact sensitization in a repeated insult patch test involving 202 healthy volunteers. In non-US post-marketing surveillance for ERTACZO® (sertaconazole nitrate) Cream, 2%, the following cutaneous adverse events were reported: contact dermatitis, erythema, pruritus, vesiculation, desquamation, and hyperpigmentation.

Read the Ertaczo (sertaconazole nitrate) Side Effects Center for a complete guide to possible side effects »

DRUG INTERACTIONS

Drug/Laboratory Test Interactions: Potential interactions between ERTACZO® (sertaconazole nitrate) Cream, 2%, and other drugs or laboratory tests have not been systematically evaluated.

Last reviewed on RxList: 12/29/2008
This monograph has been modified to include the generic and brand name in many instances.

WARNINGS

ERTACZO® (sertaconazole nitrate) Cream, 2%, is not indicated for ophthalmic, oral or intravaginal use.

PRECAUTIONS

General: ERTACZO® (sertaconazole nitrate) Cream, 2%, is for use on the skin only. If irritation or sensitivity develops with the use of ERTACZO® (sertaconazole nitrate) Cream, 2%, treatment should be discontinued and appropriate therapy instituted.

Diagnosis of the disease should be confirmed either by direct microscopic examination of infected superficial epidermal tissue in a solution of potassium hydroxide or by culture on an appropriate medium.

Physicians should exercise caution when prescribing ERTACZO® (sertaconazole nitrate) Cream, 2%, to patients known to be sensitive to imidazole antifungals, since cross-reactivity may occur.

Carcinogenesis, Mutagenesis, Impairment of Fertility

Long-term studies to evaluate the car-cinogenic potential of sertaconazole nitrate have not been conducted. No clastogenic potential was observed in a mouse micronucleus test. Sertaconazole nitrate was considered negative for sister chromatid exchange (SCE) in the in vivo mouse bone marrow SCE assay. There was no evidence that sertaconazole nitrate induced unscheduled DNA synthesis in rat primary hepatocyte cultures. Sertaconazole nitrate exhibited no toxicity or adverse effects on reproductive performance or fertility of male or female rats given up to 60 mg/kg/day orally by gastric intubation (16 times the maximum recommended human dose based on a body surface area comparison).

Pregnancy

Teratogenic Effects

Pregnancy Category C: Oral reproduction studies in rats and rabbits did not produce any evidence of maternal toxicity, embryotoxicity or teratogenicity of ser-taconazole nitrate at an oral dose of 160 mg/kg/day (40 times (rats) and 80 times (rabbits) the maximum recommended human dose on a body surface area comparison). In an oral peri-postnatal study in rats, a reduction in live birth indices and an increase in the number of still-born pups was seen at 80 and 160 mg/kg/day.

There are no adequate and well-controlled studies that have been conducted on topically applied ERTACZO® (sertaconazole nitrate) Cream, 2%, in pregnant women. Because animal reproduction studies are not always predictive of human response, ERTACZO® (sertaconazole nitrate) Cream, 2%, should be used during pregnancy only if clearly needed.

Nursing Mothers

It is not known if sertaconazole is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when prescribing ERTACZO® (sertaconazole nitrate) Cream, 2%, to a nursing woman.

Pediatric Use

The efficacy and safety of ERTACZO® (sertaconazole nitrate) Cream, 2%, have not been established in pediatric patients below the age of 12 years.

Geriatric Use

Clinical studies of ERTACZO® (sertaconazole nitrate) Cream, 2%, did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.

Last reviewed on RxList: 12/29/2008
This monograph has been modified to include the generic and brand name in many instances.

OVERDOSE

Overdosage with ERTACZO® (sertaconazole nitrate) Cream, 2%, has not been reported to date. ERTACZO® (sertaconazole nitrate) Cream, 2%, is intended for topical dermatologic use only. It is not for oral, ophthalmic, or intravaginal use.

CONTRAINDICATIONS

ERTACZO® (sertaconazole nitrate) Cream, 2%, is contraindicated in patients who have a known or suspected sensitivity to sertaconazole nitrate or any of its components or to other imidazoles.

Last reviewed on RxList: 12/29/2008
This monograph has been modified to include the generic and brand name in many instances.

CLINICAL PHARMACOLOGY

Pharmacokinetics

In a multiple dose pharmacokinetic study that included 5 male patients with interdigital tinea pedis (range of diseased area, 42 - 140 cm²; mean, 93 cm²), ERTACZO® (sertaconazole nitrate) Cream, 2%, was topically applied every 12 hours for a total of 13 doses to the diseased skin (0.5 grams sertaconazole nitrate per 100 cm²). Sertaconazole concentrations in plasma measured by serial blood sampling for 72 hours after the thirteenth dose were below the limit of quantitation (2.5 ng/mL) of the analytical method used.

Microbiology

Sertaconazole is an antifungal that belongs to the imidazole class of antifungals. While the exact mechanism of action of this class of antifungals is not known, it is believed that they act primarily by inhibiting the cytochrome P450-dependent synthesis of ergosterol. Ergosterol is a key component of the cell membrane of fungi, and lack of this component leads to fungal cell injury primarily by leakage of key constituents in the cytoplasm from the cell.

Activity In Vivo

Sertaconazole nitrate has been shown to be active against isolates of the fol-lowing microorganisms in clinical infections as described in the INDICATIONS AND USAGE section:

Trichophyton rubrum
Trichophyton mentagrophytes
Epidermophyton floccosum

Clinical studies

In two randomized, double-blind, clinical trials, patients 12 years and older with interdigital tinea pedis applied either ERTACZO® (sertaconazole nitrate) Cream, 2%, or vehicle, twice daily for four weeks.Patients with moccasin-type (plantar) tinea pedis and/or onychomycosis were excluded from the study. Two weeks after completion of therapy (six weeks after beginning therapy), patients were evaluated for signs and symptoms related to interdigital tinea pedis.

Treatment outcomes are summarized in the table below.

Treatment Outcomes as Percent (%) of Total Subjects

  Study 1 Study 2
Sertaconazole Vehicle Sertaconazole Vehicle
Complete Cure*
(Primary Efficacy Variable)
13/99 (13.1%) 3/92 (3.3 %) 28/103 (27.2%) 5/103 (4.9%)
Effective Treatment** 32/99 (32.3%) 11/92 (12.0%) 52/103 (50.5%) 16/103 (15.5%)
Mycological Cure*** 49/99 (49.5%) 18/92 (19.6%) 71/103 (68.9%) 20/103 (19.4%)
*Complete Cure - Patients who had complete clearing of signs and symptoms and Mycological Cure.
** Effective Treatment - Patients who had minimal residual signs and symptoms of interdigital tinea pedis and Mycological Cure.
*** Mycological Cure - Patients who had both negative microscopic KOH preparation and a negative fungal culture.

In clinical trials, complete cure in sertaconazole treated patients was achieved in 32 of 160 (20%) patients with Trichophyton rubrum, in 7 of 28 (25%) patients with Trichophyton menta-grophytes and in 2 of 13 (15%) patients with Epidermophyton floccosum.

Last reviewed on RxList: 12/29/2008
This monograph has been modified to include the generic and brand name in many instances.

PATIENT INFORMATION

The patient should be instructed to:

  1. Use ERTACZO® (sertaconazole nitrate) Cream, 2%, as directed by the physician. The hands should be washed after applying the medication to the affected area(s). Avoid contact with the eyes, nose, mouth and other mucous membranes. ERTACZO® (sertaconazole nitrate) Cream, 2%, is for external use only.
  2. Dry the affected area(s) thoroughly before application, if you wish to use ERTACZO® (sertaconazole nitrate) Cream, 2%, after bathing.
  3. Use the medication for the full treatment time recommended by the physician, even though symptoms may have improved. Notify the physician if there is no improvement after the end of the prescribed treatment period, or sooner, if the condition worsens.
  4. Inform the physician if the area of application shows signs of increased irritation, redness, itching, burning, blistering, swelling or oozing.
  5. Avoid the use of occlusive dressings unless otherwise directed by the physician.
  6. Do not use this medication for any disorder other than that for which it was prescribed.

Last reviewed on RxList: 12/29/2008
This monograph has been modified to include the generic and brand name in many instances.

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PATIENT INFORMATION

The patient should be instructed to:

  1. Use ERTACZO® (sertaconazole nitrate) Cream, 2%, as directed by the physician. The hands should be washed after applying the medication to the affected area(s). Avoid contact with the eyes, nose, mouth and other mucous membranes. ERTACZO® (sertaconazole nitrate) Cream, 2%, is for external use only.
  2. Dry the affected area(s) thoroughly before application, if you wish to use ERTACZO® (sertaconazole nitrate) Cream, 2%, after bathing.
  3. Use the medication for the full treatment time recommended by the physician, even though symptoms may have improved. Notify the physician if there is no improvement after the end of the prescribed treatment period, or sooner, if the condition worsens.
  4. Inform the physician if the area of application shows signs of increased irritation, redness, itching, burning, blistering, swelling or oozing.
  5. Avoid the use of occlusive dressings unless otherwise directed by the physician.
  6. Do not use this medication for any disorder other than that for which it was prescribed.

Last reviewed on RxList: 12/29/2008
This monograph has been modified to include the generic and brand name in many instances.

Disclaimer

Ertaczo Consumer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

SERTACONAZOLE - TOPICAL

(ser-ta-CAW-nah-zole)

COMMON BRAND NAME(S): Ertaczo

USES: This medication is used to treat athlete's foot. It is an azole antifungal that works by preventing the growth of fungus.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This medication may also be used for other fungal skin infections such as ringworm or jock itch.

HOW TO USE: Use this medication on the skin only. Clean and thoroughly dry the area to be treated. Apply this medication to the affected skin twice daily or as directed by your doctor. Apply enough medication to cover the affected skin and some of the surrounding skin. After applying this medication, wash your hands. Do not wrap, cover or bandage the area unless directed to do so by your doctor. Do not apply this more often than prescribed. Your condition will not clear faster, but side effects may be increased.

Do not apply this medication in the eyes, nose, mouth, or vagina.

Use this medication regularly in order to get the most benefit from it. Remember to use it at the same times each day.

Continue to use this medication until the full prescribed amount is finished, even if symptoms disappear after starting sertaconazole. Stopping the medication too early may allow the fungus to continue to grow, which may result in a relapse of the infection.

Inform your doctor if your condition persists after 2 weeks of treatment or worsens at any time.

Disclaimer

Ertaczo Consumer (continued)

SIDE EFFECTS: Burning, swelling, irritation, tenderness, discoloration, or dry skin may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: blistering, oozing, open sores.

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the Ertaczo (sertaconazole nitrate) Side Effects Center for a complete guide to possible side effects »

PRECAUTIONS: Before using sertaconazole, tell your doctor or pharmacist if you are allergic to it; or to other azole antifungals such as clotrimazole, ketoconazole, or miconazole; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

Disclaimer

Ertaczo Consumer (continued)

DRUG INTERACTIONS: Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use.

Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

OVERDOSE: This medicine may be harmful if swallowed. If swallowing is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.

NOTES: Do not share this medication with others.

This medication has been prescribed for your current condition only. Do not use it later for another infection unless told to do so by your doctor. A different medication may be necessary in those cases.

MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

STORAGE: Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised May 2010. Copyright(c) 2010 First Databank, Inc.

Ertaczo Patient Information Including Side Effects

Brand Names: Ertaczo

Generic Name: sertaconazole topical (Pronunciation: ser ta CAW nah zole)

What is sertaconazole topical (Ertaczo)?

Sertaconazole topical is an antifungal medication. Sertaconazole topical prevents fungus from growing on the skin.

Sertaconazole topical is used to treat fungal infections of the skin such as athlete's foot.

Sertaconazole topical may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of sertaconazole topical (Ertaczo)?

Serious side effects are not expected to occur with the use of sertaconazole topical. Stop using sertaconazole topical and contact your doctor if you experience unusual or severe itching, redness, burning, blistering, swelling, oozing, or irritation of the skin.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Read the Ertaczo (sertaconazole nitrate) Side Effects Center for a complete guide to possible side effects »

What is the most important information I should know about sertaconazole topical (Ertaczo)?

Use this medication for the full amount of time prescribed. Your symptoms may start to improve before the infection is completely healed, however it is important to complete the full course of treatment.

Do not use bandages or dressings that do not allow air circulation over the affected area (occlusive dressings) unless otherwise directed by your doctor. If the affected area is the feet, be sure to wear clean, cotton socks and sandals or shoes that allow air circulation.

Do not get this medication in the eyes, nose, or mouth. If this happens, rinse with water and seek medical attention if irritation occurs.

Side Effects Centers

Ertaczo Patient Information including How Should I Take

What should I discuss with my healthcare provider before using sertaconazole topical (Ertaczo)?

Do not use sertaconazole topical without first talking to your doctor if you have had an allergic reaction to it in the past.

Sertaconazole topical is in the FDA pregnancy category C. This means that it is not known whether sertaconazole topical will be harmful to an unborn baby. Do not use this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment.

It is not known whether sertaconazole passes into breast milk. Do not use sertaconazole topical without first talking to your doctor if you are breast-feeding a baby.

How should I use sertaconazole topical (Ertaczo)?

Use sertaconazole exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Wash your hands before and after using this medication.

If the cream is used after bathing or showering, dry the skin thoroughly before application.

Apply the cream to the affected area twice a day as directed by your healthcare provider.

Use this medication for the full amount of time prescribed. Your symptoms may start to improve before the infection is completely healed, however it is important to complete the full course of treatment.

It is important to use sertaconazole topical regularly to get the most benefit.

If the infection does not clear up in a few weeks, or if it appears to get worse, contact your doctor.

Do not use bandages or dressings that do not allow air circulation over the affected area (occlusive dressings) unless otherwise directed by your doctor. If the affected area is the feet, be sure to wear clean, cotton socks and sandals or shoes that allow air circulation.

Do not get this medication in the eyes, nose, or mouth. If this happens, rinse with water and seek medical attention if irritation occurs.

Store sertaconazole topical at room temperature away from moisture and heat.

Side Effects Centers

Ertaczo Patient Information including If I Miss a Dose

What happens if I miss a dose (Ertaczo)?

Apply the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the dose you missed and apply only the regular amount of sertaconazole topical. Do not use a double dose unless otherwise directed by your doctor.

What happens if I overdose (Ertaczo)?

An overdose of sertaconazole topical is unlikely to threaten life. If an overdose is suspected or if sertaconazole topical has been ingested, contact an emergency room or a poison control center for advice.

What should I avoid while using sertaconazole topical (Ertaczo)?

Do not use bandages or dressings that do not allow air circulation over the affected area (occlusive dressings) unless otherwise directed by your doctor. A light cotton-gauze dressing may be used to protect clothing, unless otherwise directed by your doctor. If the affected area is the feet, be sure to wear clean, cotton socks and sandals or shoes that allow air circulation.

What other drugs will affect sertaconazole topical (Ertaczo)?

Do not use other topical products on the treated area, unless otherwise directed by your doctor. Other topical products may affect the absorption or effectiveness of sertaconazole topical.

Although it is unlikely that sertaconazole topical will interact with other medications taken by mouth, some interactions may occur. Talk to your doctor and pharmacist before taking or using any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Where can I get more information?

Your pharmacist has additional information about sertaconazole written for health professionals that you may read.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 1.04. Revision date: 12/15/2010.

Your use of the content provided in this service indicates that you have read,understood and agree to the End-User License Agreement,which can be accessed by clicking on this link.

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Side Effects Centers

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