Lacrisert (Cellulose)
برای این دارو، اطلاعات عمومی (فارسی) یافت نشد . برای افزودن اطلاعات فارسی به این دارو کلیک نمایید.
Lacrisert (Cellulose)

LACRISERT®
(hydroxypropyl cellulose ophthalmic insert)

DRUG DESCRIPTION

LACRISERT* (hydroxypropyl cellulose ophthalmic insert) is a sterile, translucent, rod-shaped, water soluble, ophthalmic insert made of hydroxypropyl cellulose, for administration into the inferior cul-de-sac of the eye.

The chemical name for hydroxypropyl cellulose is cellulose, 2-hydroxypropyl ether. It is an ether of cellulose in which hydroxypropyl groups (-CH2CHOHCH3) are attached to the hydroxyls present in the anhydroglucose rings of cellulose by ether linkages. A representative structure of the monomer is:

LACRISERT® (HYDROXYPROPYL CELLULOSE OPHTHALMIC INSERT) Structural Formula Illustration

The molecular weight is typically 1 x 106.

Hydroxypropyl cellulose is an off-white, odorless, tasteless powder. It is soluble in water below 38°C, and in many polar organic solvents such as ethanol, propylene glycol, dioxane, methanol, isopropyl alcohol (95%), dimethyl sulfoxide, and dimethyl formamide.

Each LACRISERT is 5 mg of hydroxypropyl cellulose. LACRISERT (cellulose) contains no preservatives or other ingredients. It is about 1.27 mm in diameter by about 3.5 mm long.

LACRISERT (cellulose) is supplied in packages of 60 units, together with illustrated instructions and a special applicator for removing LACRISERT (cellulose) from the unit dose blister and inserting it into the eye. A spare applicator is included in each package.

What are the precautions when taking cellulose (Lacrisert)?

Before using hydroxypropyl cellulose, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: eye surgery/injury/infection/disease.

After you apply this drug, your vision may become temporarily blurred. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this...

Read All Potential Precautions of Lacrisert »

*Registered trademark of ATON PHARMA, INC. COPYRIGHT © ATON PHARMA, INC., 2007 All rights reserved

What are the precautions when taking cellulose (Lacrisert)?

Before using hydroxypropyl cellulose, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: eye surgery/injury/infection/disease.

After you apply this drug, your vision may become temporarily blurred. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this...

Read All Potential Precautions of Lacrisert »

Last reviewed on RxList: 3/13/2008
This monograph has been modified to include the generic and brand name in many instances.

INDICATIONS

LACRISERT (cellulose) is indicated in patients with moderate to severe dry eye syndromes, including keratoconjunctivitis sicca. LACRISERT (cellulose) is indicated especially in patients who remain symptomatic after an adequate trial of therapy with artificial tear solutions.

LACRISERT (cellulose) is also indicated for patients with:

Exposure keratitis
Decreased corneal sensitivity
Recurrent corneal erosions

DOSAGE AND ADMINISTRATION

One LACRISERT (cellulose) ophthalmic insert in each eye once daily is usually sufficient to relieve the symptoms associated with moderate to severe dry eye syndromes. Individual patients may require more flexibility in the use of LACRISERT (cellulose) ; some patients may require twice daily use for optimal results.

Clinical experience with LACRISERT (cellulose) indicates that in some patients several weeks may be required before satisfactory improvement of symptoms is achieved.

LACRISERT (cellulose) is inserted into the inferior cul-de-sac of the eye beneath the base of the tarsus, not in apposition to the cornea, nor beneath the eyelid at the level of the tarsal plate. If not properly positioned, it will be expelled into the interpalpebral fissure, and may cause symptoms of a foreign body. Illustrated instructions are included in each package. While in the licensed practitioner's office, the patient should read the instructions, then practice insertion and removal of LACRISERT (cellulose) until proficiency is achieved.

NOTE: Occasionally LACRISERT (cellulose) is inadvertently expelled from the eye, especially in patients with shallow conjunctival fornices. The patient should be cautioned against rubbing the eye(s) containing LACRISERT (cellulose) , especially upon awakening, so as not to dislodge or expel the insert. If required, another LACRISERT (cellulose) ophthalmic insert may be inserted. If experience indicates that transient blurred vision develops in an individual patient, the patient may want to remove LACRISERT (cellulose) a few hours after insertion to avoid this. Another LACRISERT (cellulose) ophthalmic insert maybe inserted if needed.

If LACRISERT (cellulose) causes worsening of symptoms, the patient should be instructed to inspect the conjunctival sac to make certain LACRISERT (cellulose) is in the proper location, deep in the inferior cul-de-sac of the eye beneath the base of the tarsus. If these symptoms persist, LACRISERT (cellulose) should be removed and the patient should contact the practitioner.

HOW SUPPLIED

LACRISERT (cellulose) , a sterile, translucent, rod-shaped, water-soluble, ophthalmic insert made of hydroxypropyl cellulose, 5 mg, is supplied as follows:

NDC 25010-805-68 in packages containing 60 unit doses (each wrapped in an aluminum blister), two reusable applicators, and a plastic storage container to store the applicators after use.

Storage

Store below 30°C (86°F).

Distributed by: ATON PHARMA, INC. Lawrenceville, NJ 08648, USA. Manufactured by: Merck and Co., Inc. West Point, PA 19486 USA. Issued June 2007. FDA rev date: 2/21/2008

Last reviewed on RxList: 3/13/2008
This monograph has been modified to include the generic and brand name in many instances.

SIDE EFFECTS

The following adverse reactions have been reported in patients treated with LACRISERT (cellulose) , but were in most instances mild and transient:

Transient blurring of vision (See PRECAUTIONS)
 Ocular discomfort or irritation
 Matting or stickiness of eyelashes
 Photophobia
 Hypersensitivity
 Edema of the eyelids
 Hyperemia

Read the Lacrisert (cellulose) Side Effects Center for a complete guide to possible side effects »

DRUG INTERACTIONS

Application of hydroxypropyl cellulose ophthalmic inserts to the eyes of unanesthetized rabbits immediately prior to or two hours before instilling pilocarpine, proparacaine HCl (0.5%), or phenylephrine (5%) did not markedly alter the magnitude and/or duration of the miotic, local corneal anesthetic, or mydriatic activity, respectively, of these agents. Under various treatment schedules, the anti-inflammatory effect of ocularly instilled dexamethasone (0.1%) in unanesthetized rabbits with primary uveitis was not affected by the presence of hydroxypropyl cellulose inserts.

Last reviewed on RxList: 3/13/2008
This monograph has been modified to include the generic and brand name in many instances.

WARNINGS

Instructions for inserting and removing LACRISERT (cellulose) should be carefully followed.

PRECAUTIONS

General

If improperly placed, LACRISERT (cellulose) may result in corneal abrasion (see DOSAGE AND ADMINISTRATION).

Information for Patients

Patients should be advised to follow the instructions for using LACRISERT (cellulose) which accompany the package.

Because this product may produce transient blurring of vision, patients should be instructed to exercise caution when operating hazardous machinery or driving a motor vehicle.

Carcinogenesis, Mutagenesis, Impairment of Fertility

Feeding of hydroxypropyl cellulose to rats at levels up to 5% of their diet produced no gross or histopathologic changes or other deleterious effects.

Pediatric Use

Safety and effectiveness in pediatric patients have not been established.

Geriatric Use

No overall differences in safety or effectiveness have been observed between elderly and younger patients.

Last reviewed on RxList: 3/13/2008
This monograph has been modified to include the generic and brand name in many instances.

OVERDOSE

No information provided.

CONTRAINDICATIONS

LACRISERT (cellulose) is contraindicated in patients who are hypersensitive to hydroxypropyl cellulose.

Last reviewed on RxList: 3/13/2008
This monograph has been modified to include the generic and brand name in many instances.

CLINICAL PHARMACOLOGY

Pharmacodynamics

LACRISERT (cellulose) acts to stabilize and thicken the precorneal tear film and prolong the tear film breakup time which is usually accelerated in patients with dry eye states. LACRISERT (cellulose) also acts to lubricate and protect the eye.

LACRISERT (cellulose) usually reduces the signs and symptoms resulting from moderate to severe dry eye syndromes, such as conjunctival hyperemia, corneal and conjunctival staining with rose bengal, exudation, itching, burning, foreign body sensation, smarting, photophobia, dryness and blurred or cloudy vision. Progressive visual deterioration which occurs in some patients may be retarded, halted, or sometimes reversed.

In a multicenter crossover study the 5 mg LACRISERT (cellulose) administered once a day during the waking hours was compared to artificial tears used four or more times daily. There was a prolongation of tear film breakup time and a decrease in foreign body sensation associated with dry eye syndrome in patients during treatment with inserts as compared to artificial tears; these findings were statistically significantly different between the treatment groups. Improvement, as measured by amelioration of symptoms, by slit lamp examination and by rose bengal staining of the cornea and conjunctiva, was greater in most patients with moderate to severe symptoms during treatment with LACRISERT (cellulose) . Patient comfort was usually better with LACRISERT (cellulose) than with artificial tears solution, and most patients preferred LACRISERT (cellulose) .

In most patients treated with LACRISERT (cellulose) for over one year, improvement was observed as evidenced by amelioration of symptoms generally associated with keratoconjunctivitis sicca such as burning, tearing, foreign body sensation, itching, photophobia and blurred or cloudy vision.

During studies in healthy volunteers, a thickened precorneal tear film was usually observed through the slit-lamp while LACRISERT (cellulose) was present in the conjunctival sac.

Pharmacokinetics and Metabolism

Hydroxypropyl cellulose is a physiologically inert substance. In a study of rats fed hydroxypropyl cellulose or unmodified cellulose at levels up to 5% of their diet, it was found that the two were biologically equivalent in that neither was metabolized.

Studies conducted in rats fed 14C-labeled hydroxypropyl cellulose demonstrated that when orally administered, hydroxypropyl cellulose is not absorbed from the gastrointestinal tract and is quantitatively excreted in the feces.

Dissolution studies in rabbits showed that hydroxypropyl cellulose inserts became softer within 1 hour after they were placed in the conjunctival sac. Most of the inserts dissolved completely in 14 to 18 hours; with a single exception, all had disappeared by 24 hours after insertion. Similar dissolution of the inserts was observed during prolonged administration (up to 54 weeks).

Last reviewed on RxList: 3/13/2008
This monograph has been modified to include the generic and brand name in many instances.

PATIENT INFORMATION

LACRISERT (cellulose) ®
(hydroxypropyl cellulose ophthalmic insert)

Note: Your licensed practitioner or a trained associate can demonstrate the proper use of LACRISERT (cellulose) *. Please read and follow these instructions carefully for your subsequent use.

Clinical experience with LACRISERT (cellulose) indicates that in some patients several weeks may be required before satisfactory improvement of symptoms is achieved.

Two applicators (one spare) are supplied with each package.

Before opening the package of LACRISERT (cellulose) , wash your hands thoroughly with soap and water.

Open blister pocket slowly and smoothly by peeling back label area - illustration

STEP 1: On a flat surface, open blister pocket slowly and smoothly by peeling back label area. Each blister pocket contains one LACRISERT (cellulose) ophthalmic insert.

Open applicator package with label side up-  Illustration

STEP 2: Open applicator package with label side up. Avoid touching grooved tip of the applicator. Pick up applicator by the wide end and rinse the tip thoroughly under hot running tap water. Gently shake off excess water.

Hold applicator with tip facing down and with forefinger on top to guide and apply gentle pressure -  Illustration

STEP 3: Hold applicator with tip facing down and with forefinger on top to guide and apply gentle pressure. Lightly press the grooved tip of the applicator onto the LACRISERT (cellulose) ophthalmic insert and it will adhere to the applicator.

It is important to follow STEPS 4 and 5 carefully or you might experience difficulty in keeping LACRISERT (hydroxypropyl cellulose ophthalmic insert) in your eye.

Pull the lid away from the eyeball and create a pocket between the white part of the eyeball and the lid - Illustration

STEP 4: Look into a mirror. Starting with the right eye, turn your head to the right so that the colored part of the eye is close to your nose. Use your free hand to grasp the lower lid between the thumb and index finger. Pull the lid away from the eyeball and create a pocket between the white part of the eyeball and the lid.

Place the tip of the applicator containing LACRISERT into the pocket. - Illustration

STEP 5: Place the tip of the applicator containing LACRISERT (cellulose) into the pocket. Avoid touching the colored part of the eye.

Remove the applicator. It is important, after removing the applicator, to look down, then release the lower eyelid. LACRISERT (hydroxypropyl cellulose ophthalmic insert) should remain deep in the lower pocket recess of the eye and not near the lower eyelid.

Repeat procedure with left eye, turning head to the left so that the colored part of the eye is close to your nose.

Rinse the applicator thoroughly under hot running tap water after use. Gently shake off visible water droplets and promptly return it to the storage container. Note that the storage container provides space for a strip of two LACRISERT (cellulose) ophthalmic inserts next to the applicator storage compartment.

IMPORTANT

If LACRISERT (cellulose) causes worsening of symptoms, or if new symptoms develop, it should be removed and your prescriber contacted.

Should the removal of the LACRISERT (cellulose) ophthalmic insert be necessary, follow these instructions.

  1. Locate LACRISERT (cellulose) by pulling the lid away from the eyeball while looking for LACRISERT (cellulose) in a mirror.
  2. Then close the eyelids.
  3. When located, move LACRISERT (cellulose) upward with your fingers through the closed eyelids.
  4. Keep the lids against the eyeball and LACRISERT (cellulose) should slip over the lid margin so that you can remove it with a clean facial tissue without touching the colored part of the eye.

CAUTION: Because this product may produce transient blurring of vision, you should exercise caution when operating hazardous machinery or driving a motor vehicle.

Store below 30°C (86°F).

Last reviewed on RxList: 3/13/2008
This monograph has been modified to include the generic and brand name in many instances.

>

PATIENT INFORMATION

LACRISERT (cellulose) ®
(hydroxypropyl cellulose ophthalmic insert)

Note: Your licensed practitioner or a trained associate can demonstrate the proper use of LACRISERT (cellulose) *. Please read and follow these instructions carefully for your subsequent use.

Clinical experience with LACRISERT (cellulose) indicates that in some patients several weeks may be required before satisfactory improvement of symptoms is achieved.

Two applicators (one spare) are supplied with each package.

Before opening the package of LACRISERT (cellulose) , wash your hands thoroughly with soap and water.

Open blister pocket slowly and smoothly by peeling back label area - illustration

STEP 1: On a flat surface, open blister pocket slowly and smoothly by peeling back label area. Each blister pocket contains one LACRISERT (cellulose) ophthalmic insert.

Open applicator package with label side up-  Illustration

STEP 2: Open applicator package with label side up. Avoid touching grooved tip of the applicator. Pick up applicator by the wide end and rinse the tip thoroughly under hot running tap water. Gently shake off excess water.

Hold applicator with tip facing down and with forefinger on top to guide and apply gentle pressure -  Illustration

STEP 3: Hold applicator with tip facing down and with forefinger on top to guide and apply gentle pressure. Lightly press the grooved tip of the applicator onto the LACRISERT (cellulose) ophthalmic insert and it will adhere to the applicator.

It is important to follow STEPS 4 and 5 carefully or you might experience difficulty in keeping LACRISERT (hydroxypropyl cellulose ophthalmic insert) in your eye.

Pull the lid away from the eyeball and create a pocket between the white part of the eyeball and the lid - Illustration

STEP 4: Look into a mirror. Starting with the right eye, turn your head to the right so that the colored part of the eye is close to your nose. Use your free hand to grasp the lower lid between the thumb and index finger. Pull the lid away from the eyeball and create a pocket between the white part of the eyeball and the lid.

Place the tip of the applicator containing LACRISERT into the pocket. - Illustration

STEP 5: Place the tip of the applicator containing LACRISERT (cellulose) into the pocket. Avoid touching the colored part of the eye.

Remove the applicator. It is important, after removing the applicator, to look down, then release the lower eyelid. LACRISERT (hydroxypropyl cellulose ophthalmic insert) should remain deep in the lower pocket recess of the eye and not near the lower eyelid.

Repeat procedure with left eye, turning head to the left so that the colored part of the eye is close to your nose.

Rinse the applicator thoroughly under hot running tap water after use. Gently shake off visible water droplets and promptly return it to the storage container. Note that the storage container provides space for a strip of two LACRISERT (cellulose) ophthalmic inserts next to the applicator storage compartment.

IMPORTANT

If LACRISERT (cellulose) causes worsening of symptoms, or if new symptoms develop, it should be removed and your prescriber contacted.

Should the removal of the LACRISERT (cellulose) ophthalmic insert be necessary, follow these instructions.

  1. Locate LACRISERT (cellulose) by pulling the lid away from the eyeball while looking for LACRISERT (cellulose) in a mirror.
  2. Then close the eyelids.
  3. When located, move LACRISERT (cellulose) upward with your fingers through the closed eyelids.
  4. Keep the lids against the eyeball and LACRISERT (cellulose) should slip over the lid margin so that you can remove it with a clean facial tissue without touching the colored part of the eye.

CAUTION: Because this product may produce transient blurring of vision, you should exercise caution when operating hazardous machinery or driving a motor vehicle.

Store below 30°C (86°F).

Last reviewed on RxList: 3/13/2008
This monograph has been modified to include the generic and brand name in many instances.

Disclaimer

Lacrisert Consumer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

HYDROXYPROPYL CELLULOSE INSERT - OPHTHALMIC

(hye-DROX-ee-PROE-pil SEL-ue-lose)

COMMON BRAND NAME(S): Lacrisert

USES: This medication is an insert that is placed in your eye to treat dry eyes. It is usually used when an artificial tears solution is not successful. This medication may also be used to treat certain other eye disorders (keratitis, decreased corneal sensitivity). It works by keeping the eye moist, helping to protect the eye from injury and infection and to decrease symptoms of dry eyes such as burning, itching, and feeling as if something is in the eye.

HOW TO USE: Read the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill. Learn all preparation and usage instructions. If you have any questions, consult your doctor or pharmacist.

To apply this medication, wash your hands first. To avoid contamination, do not touch the insert or let it touch any other surface besides the applicator.

If you wear contact lenses, remove them before using this medication. Ask your doctor when you may replace your contact lenses.

Use the supplied applicator to place 1 insert into the eye, usually 1 to 2 times daily or as directed by your doctor.

Rinse the applicator with hot running water after use. Shake off any visible water droplets, and then replace the applicator in the storage container.

Avoid rubbing your eyes when using this medication. If the insert comes out, you may replace it with another one.

Your doctor may direct you to also use an artificial tears solution or saline drops with this medication. Use those medications exactly as prescribed.

Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time(s) each day.

It may take several weeks to see the full benefit of this medication. Tell your doctor if your condition does not improve or worsens.

Disclaimer

Lacrisert Consumer (continued)

SIDE EFFECTS: Eye discomfort/irritation/redness, tearing, eye sensitivity to light, sticky eyelashes, or temporary blurred vision may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Remove the insert and tell your doctor immediately if any of these unlikely but serious side effects occur: eye pain, persistent eye redness/irritation, swelling in or around the eyes, vision changes.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the Lacrisert (cellulose) Side Effects Center for a complete guide to possible side effects »

PRECAUTIONS: Before using hydroxypropyl cellulose, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: eye surgery/injury/infection/disease.

After you apply this drug, your vision may become temporarily blurred. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

Disclaimer

Lacrisert Consumer (continued)

DRUG INTERACTIONS: Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: other eye medications.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

OVERDOSE: This medicine may be harmful if swallowed. If swallowing or overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center.

NOTES: Do not share this medication with others.

MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

STORAGE: Store at room temperature below 86 degrees F (30 degrees C) away from heat. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised May 2010. Copyright(c) 2010 First Databank, Inc.

LACRISERT®
(hydroxypropyl cellulose ophthalmic insert)

DRUG DESCRIPTION

LACRISERT* (hydroxypropyl cellulose ophthalmic insert) is a sterile, translucent, rod-shaped, water soluble, ophthalmic insert made of hydroxypropyl cellulose, for administration into the inferior cul-de-sac of the eye.

The chemical name for hydroxypropyl cellulose is cellulose, 2-hydroxypropyl ether. It is an ether of cellulose in which hydroxypropyl groups (-CH2CHOHCH3) are attached to the hydroxyls present in the anhydroglucose rings of cellulose by ether linkages. A representative structure of the monomer is:

LACRISERT® (HYDROXYPROPYL CELLULOSE OPHTHALMIC INSERT) Structural Formula Illustration

The molecular weight is typically 1 x 106.

Hydroxypropyl cellulose is an off-white, odorless, tasteless powder. It is soluble in water below 38°C, and in many polar organic solvents such as ethanol, propylene glycol, dioxane, methanol, isopropyl alcohol (95%), dimethyl sulfoxide, and dimethyl formamide.

Each LACRISERT is 5 mg of hydroxypropyl cellulose. LACRISERT (cellulose) contains no preservatives or other ingredients. It is about 1.27 mm in diameter by about 3.5 mm long.

LACRISERT (cellulose) is supplied in packages of 60 units, together with illustrated instructions and a special applicator for removing LACRISERT (cellulose) from the unit dose blister and inserting it into the eye. A spare applicator is included in each package.

*Registered trademark of ATON PHARMA, INC. COPYRIGHT © ATON PHARMA, INC., 2007 All rights reserved

Last reviewed on RxList: 3/13/2008
This monograph has been modified to include the generic and brand name in many instances.

LACRISERT®
(hydroxypropyl cellulose ophthalmic insert)

DRUG DESCRIPTION

LACRISERT* (hydroxypropyl cellulose ophthalmic insert) is a sterile, translucent, rod-shaped, water soluble, ophthalmic insert made of hydroxypropyl cellulose, for administration into the inferior cul-de-sac of the eye.

The chemical name for hydroxypropyl cellulose is cellulose, 2-hydroxypropyl ether. It is an ether of cellulose in which hydroxypropyl groups (-CH2CHOHCH3) are attached to the hydroxyls present in the anhydroglucose rings of cellulose by ether linkages. A representative structure of the monomer is:

LACRISERT® (HYDROXYPROPYL CELLULOSE OPHTHALMIC INSERT) Structural Formula Illustration

The molecular weight is typically 1 x 106.

Hydroxypropyl cellulose is an off-white, odorless, tasteless powder. It is soluble in water below 38°C, and in many polar organic solvents such as ethanol, propylene glycol, dioxane, methanol, isopropyl alcohol (95%), dimethyl sulfoxide, and dimethyl formamide.

Each LACRISERT is 5 mg of hydroxypropyl cellulose. LACRISERT (cellulose) contains no preservatives or other ingredients. It is about 1.27 mm in diameter by about 3.5 mm long.

LACRISERT (cellulose) is supplied in packages of 60 units, together with illustrated instructions and a special applicator for removing LACRISERT (cellulose) from the unit dose blister and inserting it into the eye. A spare applicator is included in each package.

*Registered trademark of ATON PHARMA, INC. COPYRIGHT © ATON PHARMA, INC., 2007 All rights reserved

Last reviewed on RxList: 3/13/2008
This monograph has been modified to include the generic and brand name in many instances.

LACRISERT®
(hydroxypropyl cellulose ophthalmic insert)

DRUG DESCRIPTION

LACRISERT* (hydroxypropyl cellulose ophthalmic insert) is a sterile, translucent, rod-shaped, water soluble, ophthalmic insert made of hydroxypropyl cellulose, for administration into the inferior cul-de-sac of the eye.

The chemical name for hydroxypropyl cellulose is cellulose, 2-hydroxypropyl ether. It is an ether of cellulose in which hydroxypropyl groups (-CH2CHOHCH3) are attached to the hydroxyls present in the anhydroglucose rings of cellulose by ether linkages. A representative structure of the monomer is:

LACRISERT® (HYDROXYPROPYL CELLULOSE OPHTHALMIC INSERT) Structural Formula Illustration

The molecular weight is typically 1 x 106.

Hydroxypropyl cellulose is an off-white, odorless, tasteless powder. It is soluble in water below 38°C, and in many polar organic solvents such as ethanol, propylene glycol, dioxane, methanol, isopropyl alcohol (95%), dimethyl sulfoxide, and dimethyl formamide.

Each LACRISERT is 5 mg of hydroxypropyl cellulose. LACRISERT (cellulose) contains no preservatives or other ingredients. It is about 1.27 mm in diameter by about 3.5 mm long.

LACRISERT (cellulose) is supplied in packages of 60 units, together with illustrated instructions and a special applicator for removing LACRISERT (cellulose) from the unit dose blister and inserting it into the eye. A spare applicator is included in each package.

*Registered trademark of ATON PHARMA, INC. COPYRIGHT © ATON PHARMA, INC., 2007 All rights reserved

Last reviewed on RxList: 3/13/2008
This monograph has been modified to include the generic and brand name in many instances.

توزیع کنندگان این دارو
شرکت های تولید کننده یا وارد کننده دارو

دارونـــما
نوآوری برای سلامت

طراحی و اجرا M.Ramezani
ارتباط با ما Info@darunama.com