PEG-3350, Sodium Sulfate, Sodium Chloride, Potassium Chloride, Sodium Ascorbate, Ascorbic Acid (MoviPrep)
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PEG-3350, Sodium Sulfate, Sodium Chloride, Potassium Chloride, Sodium Ascorbate, Ascorbic Acid (MoviPrep)

MoviPrep®
(moo-vee-prep) (polyethylene glycol (PEG) 3350, sodium sulfate, sodium chloride, potassium chloride, sodium ascorbate, and ascorbic acid) For Oral Solution

DRUG DESCRIPTION

MoviPrep (PEG-3350, sodium sulfate, sodium chloride, potassium chloride, sodium ascorbate, and ascorbic acid) For Oral Solution is an osmotic laxtive consisting of 4 pouches (2 of pouch A and 2 of pouch B) containing white to yellow powder for reconstitution. Each pouch A contains 100 grams of polyethylene glycol (PEG) 3350, NF, 7.5 grams of sodium sulfate, USP, 2.691 grams of sodium chloride, USP, and 1.015 grams of potassium chloride, USP, plus the following excipients: aspartame, NF (sweetener), acesulfame potassium, NF (sweetener), and lemon flavoring. Each pouch B contains 4.7 grams of ascorbic acid, USP and 5.9 grams of sodium ascorbate, USP. When 1 pouch A and 1 pouch B are dissolved together in water to a volume of 1 liter, MoviPrep (PEG-3350, sodium sulfate, sodium chloride, potassium chloride, sodium ascorbate, and ascorbic acid) is an oral solution having a lemon taste.

The entire, reconstituted, 2-liter MoviPrep colon preparation contains 200 grams of PEG-3350, 15 grams of sodium sulfate, 5.38 grams of sodium chloride, 2.03 grams of potassium chloride, 9.4 grams of ascorbic acid, and 11.8 grams of sodium ascorbate plus the following excipients: aspartame (sweetener), acesulfame potassium (sweetener), and lemon flavoring.

A container for reconstitution is enclosed.

What are the possible side effects of polyethylene glycol electrolyte solution?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor if you have any of these serious side effects:

  • severe stomach pain or bloating;
  • no bowel movement within 2 hours after use; or
  • gagging, choking, or vomiting.

If you have any of these side effects, you may need to drink the medication more slowly, or stop using it for a short time.

Less serious side effects may include:

  • mild...

Read All Potential Side Effects and See Pictures of MoviPrep »

What are the precautions when taking peg-3350, sodium sulfate, sodium chloride, potassium chloride, sodium ascorbate, ascorbic acid (MoviPrep)?

Before taking PEG with electrolyte, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: blocked intestines (gastrointestinal obstruction), hole in the intestines, severe infection in the intestines (such as toxic colitis, toxic megacolon).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: severe ulcers/swelling of the colon (ulcerative colitis), intestines that are not moving (ileus), problems...

Read All Potential Precautions of MoviPrep »

Last reviewed on RxList: 10/5/2012
This monograph has been modified to include the generic and brand name in many instances.

INDICATIONS

MoviPrep is an osmotic laxative indicated for cleansing of the colon as a preparation for colonoscopy in adults 18 years of age or older.

DOSAGE AND ADMINISTRATION

The MoviPrep dose for colon cleansing for adult patients is 2 liters (approximately 64 ounces) of MoviPrep solution (with 1 additional liter of clear liquid) taken orally prior to the colonoscopy in one of the following ways:

  1. Spllt-dose MoviPrep regimen: The evening before the colonoscopy, take the first liter of MoviPrep solution over one hour (one 8 ounce glass every 15 minutes) and then drink 0.5 liters (approximately 16 ounces) of clear liquid. Then, on the morning of the colonoscopy, take the second liter of MoviPrep solution over one hour and then drink 0.5 liters of clear liquid at least one hour prior to the start of the colonoscopy; or
  2. Evening only (full-dose) MoviPrep regimen: Around 6 PM in the evening before the colonoscopy, take the first liter of MoviPrep solution over one hour (one 8 ounce glass every 15 minutes) and then about 1.5 hours later take the second liter of MoviPrep solution over one hour. In addition, take 1 liter (approximately 32 ounces) of additional clear liquid during the evening before the colonoscopy.

Preparation of the MoviPrep solution

MoviPrep solution is prepared by emptying the contents of 1 pouch A and 1 pouch B into a suitable glass container (or the container provided) and adding to the container 1 liter of lukewarm water. Mix the solution to ensure that the ingredients are completely dissolved. If the patient prefers, the MoviPrep solution can be refrigerated prior to drinking. The reconstituted solution should be used within 24 hours.

No additional ingredients (e.g., flavorings) should be added to the MoviPrep solution.

After consumption of the first liter of MoviPrep solution, the above mixing procedure should be repeated with the second pouch A and pouch B to reconstitute the second liter of the MoviPrep solution.

HOW SUPPLIED

Dosage Forms And Strengths

MoviPrep is available in a carton that contains 4 pouches (2 of pouch A and 2 of pouch B). Each pouch A contains 100 grams of polyethylene glycol (PEG) 3350, NF, 7.5 grams of sodium sulfate,USP, 2.691 grams of sodium chloride, USP, and 1.015 grams of potassium chloride, USP, plus the following excipients: aspartame,NF (sweetener), acesulfame potassium, NF (sweetener), and lemon flavoring. Each pouch B contains 4.7 grams of ascorbic acid, USP and 5.9grams of sodium ascorbate, USP.

Storage And Handling

MoviPrep is supplied as a white to yellow powder. MoviPrep is administered as an oral solution after reconstitution.

NDC 65649-201-75, MoviPrep, single use carton.
NDC 65649-201-76, MoviPrep, professional sample carton.

Each carton contains a disposable container for reconstitution of MoviPrep and 4 pouches (2 of pouch A and 2 of pouch B).

Storage

Store carton/container at 25°C (77°F); excursions permitted to 15- 30°C (59-86°F). When reconstituted, store upright and keep solution refrigerated. Use within 24 hours.

Manufactured by: Novel Laboratories, Inc. Somerset, NJ 08873. For: Salix Pharmaceuticals, Inc. Raleigh, NC 27615. Revised: Jan 2012

Last reviewed on RxList: 10/5/2012
This monograph has been modified to include the generic and brand name in many instances.

SIDE EFFECTS

Clinical Studies Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.

In the MoviPrep trials, abdominal distension, anal discomfort, thirst, nausea, and abdominal pain were some of the most common adverse reactions to MoviPrep administration. Since diarrhea was considered as a part of the efficacy of MoviPrep, diarrhea was not defined as an adverse reaction in the clinical studies. Tables 1 and 2 display the most common drug-related adverse reactions of MoviPrep and its comparator in the controlled MoviPrep trials.

Table 1: The Most Common Drug-Related Adverse Reactions1 (≥ 2%) in the Study of MoviPrep vs. 4 Liter Polyethylene Glycol plus Electrolytes Solution

  MoviPrep® (split dose)
N=180
4L PEG + E2
N=179
n (% = n/N) n (% = n/N)
Malaise 35 (19.4) 32 (17.9)
Nausea 26 (14.4) 36 (20.1)
Abdominal pain 24 (13.3) 27 (15.1)
Vomiting 14 (7.8) 23 (12.8)
Upper abdominal pain 10 (5.6) 11 (6.1)
Dyspepsia 5 (2.8) 2 (1.1)
1 Drug-related adverse reactions were adverse events that were possibly, probably, or definitely related to the study drug.
2 4l PEG + E is 4 liter Polyethylene Glycol plus Electrolytes Solution

Table 2: The Most Common Drug-Related Adverse Reactions1 (≥ 5%) in the Study of MoviPrep vs. 90 mL Oral Sodium Phosphate Solution

  MoviPrep® (evening-only) (full dose)
N=169
90 mL OSPS2
N=171
n (% = n/N) n (% = n/N)
Abdominal distension 101 (59.8) 70 (40.9)
Anal discomfort 87 (51.5) 89 (52.0)
Thirst 80 (47.3) 112 (65.5)
Nausea 80 (47.3) 80 (46.8)
Abdominal pain 66 (39.1) 55 (32.2)
Sleep disorder 59 (34.9) 49 (28.7)
Rigors 57 (33.7) 51 (29.8)
Hunger 51 (30.2) 121 (70.8)
Malaise 45 (26.6) 90 (52.6)
Vomiting 12 (7.1) 14 (8.2)
Dizziness 11 (6.5) 31 (18.1)
Headache 3 (1.8) 9 (5.3)
Hypokalemia 0 (0) 10 (5.8)
Hyperphosphatemia 0 (0) 10 (5.8)
1 Drug-related adverse reactions were adverse events that were possibly, probably, or definitely related to the study drug. In addition to the recording of spontaneous adverse events, patients were also specifically asked about the occurrence of the following symptoms: shivering, anal irritations, abdominal bloating or fullness, sleep loss, nausea, vomiting, weakness, hunger sensation, abdominal cramps or pain, thirst sensation, and dizziness.
2 OSPS is Oral Sodium Phosphate Solution

Isolated cases of urticaria, rhinorrhea, dermatitis, and anaphylactic reaction have been reported with PEG-based products and may represent allergic reactions.

Published literature contains isolated reports of serious adverse events following the administration of PEG-based products in patients over 60 years of age. These adverse events included upper gastrointestinal bleeding from a Mallory-Weis tear, esophageal perforation, asystole, and acute pulmonary edema after aspirating PEG-based preparation.

Postmarketing Experience

In addition to adverse reactions reported from clinical trials, the following adverse events have been identified during postapproval use of MoviPrep. Because they are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. These events have been chosen for inclusion due to either their seriousness, frequency of reporting or causal connection to MoviPrep, or a combination of these factors.

General

Hypersensitivity reactions including anaphylaxis (some of which were severe, including shock), rash, urticaria, pruritis, lip, tongue and facial swelling, dyspnea, chest tightness and throat tightness. Fever, chills and dehydration.

Read the MoviPrep (peg-3350, sodium sulfate, sodium chloride, potassium chloride, sodium ascorbate, ascorbic acid) Side Effects Center for a complete guide to possible side effects »

DRUG INTERACTIONS

Drugs That May Increase Risks Due to Fluid and Electrolyte Abnormalities

Use caution when prescribing MoviPrep for patients with conditions, or who are using medications that increase the risk for fluid and electrolyte disturbances or may increase the risk of adverse events of seizure, arrhythmias, and prolonged QT in the setting of fluid and electrolyte abnormalities. Consider additional patient evaluations as appropriate. [see WARNINGS]

Potential for Altered Drug Absorption

Oral medication administered within 1 hour of the start of administration of MoviPrep may be flushed from the gastrointestinal tract and the medication may not be absorbed.

Last reviewed on RxList: 10/5/2012
This monograph has been modified to include the generic and brand name in many instances.

WARNINGS

Included as part of the PRECAUTIONS section.

PRECAUTIONS

Serious Fluid and Electrolyte Abnormalities

Advise patients to hydrate adequately before, during, and after the use of MoviPrep. If a patient develops significant vomiting or signs of dehydration after taking MoviPrep consider performing post-colonoscopy lab tests (electrolytes, creatinine, and BUN). Fluid and electrolyte disturbances can lead to serious adverse events including cardiac arrhythmias, seizures and renal impairment.

Patients with electrolyte abnormalities should have them corrected before treatment with MoviPrep. MoviPrep should be used with caution in patients using concomitant medications that increase the risk of electrolyte abnormalities [such as diuretics, angiotensin converting enzyme (ACE)-inhibitors or angiotensin receptor blockers (ARBs)] or in patients with known or suspected hyponatremia. Consider performing pre-dose and post-colonoscopy laboratory tests (sodium, potassium, calcium, creatinine, and BUN) in these patients, [see DRUG INTERACTIONS]

Cardiac Arrhythmias

There have been rare reports of serious arrhythmias associated with the use of ionic osmotic laxative products for bowel preparation. Use caution when prescribing MoviPrep for patients at increased risk of arrhythmias (e.g., patients with a history of prolonged QT, uncontrolled arrhythmias, recent myocardial infarction, unstable angina, congestive heart failure, or cardiomyopathy). Pre-dose and post-colonoscopy ECGs should be considered in patients at increased risk of serious cardiac arrhythmias.

Seizures

There have been rare reports of generalized tonic-clonic seizures and/or loss of consciousness associated with use of bowel preparation products in patients with no prior history of seizures. The seizure cases were associated with electrolyte abnormalities (e.g., hyponatremia, hypokalemia, hypocalcemia, and hypomagnesemia) and low serum osmolality. The neurologic abnormalities resolved with correction of fluid and electrolyte abnormalities.

Use caution when prescribing MoviPrep for patients with a history of seizures and in patients at increased risk of seizure, such as patients taking medications that lower the seizure threshold (e.g., tricyclic antidepressants), patients withdrawing from alcohol or benzodiazepines, or patients with known or suspected hyponatremia.

Renal Impairment

Use with caution in patients with impaired renal function or patients taking concomitant medications that affect renal function (such as diuretics, angiotensin converting enzyme inhibitors, angiotensin receptor blockers, or non-steroidal antiinflammatory drugs). Advise these patients of the importance of adequate hydration, and consider performing pre-dose and post-colonoscopy laboratory tests (electrolytes, creatinine, and BUN) in these patients.

(Colonic) Mucosal Ulceration, Ischemic Colitis and UlcerativeColitis

Osmotic laxatives may produce colonic mucosal aphthous ulcerations and there have been reports of more serious cases of ischemic colitis requiring hospitalization. Concurrent use of stimulant laxatives and MoviPrep may increase the risk and is not recommended. The potential for mucosal ulcerations resulting from the bowel preparation should be considered when interpreting colonoscopy findings in patients with known or suspected inflammatory bowel disease.

Use in Patients with Significant Gastrointestinal Disease

If gastrointestinal obstruction or perforation is suspected, perform appropriate diagnostic studies to rule out these conditions before administering MoviPrep. If a patient experiences severe bloating, abdominal distension, or abdominal pain, administration should be slowed or temporarily discontinued until symptoms abate.

Use with caution in patients with severe ulcerative colitis.

Aspiration

Patients with impaired gag reflex and patients prone to regurgitation or aspiration should be observed during the administration of MoviPrep. Use with caution in these patients.

Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency

Since MoviPrep contains sodium ascorbate and ascorbic acid, MoviPrep should be used with caution in patients with glucose- 6-phosphate dehydrogenase (G-6-PD) deficiency, especially G-6-PD deficiency patients with an active infection, with a history of hemolysis, or taking concomitant medications known to precipitate hemolytic reactions.

Contains Phenylalanine

Phenylketonurics: Contains Phenylalanine 233 mg of phenylalanine per treatment).

Patient Counseling Information

  • Advise patients who require a diet low in phenylalanine that MoviPrep contains phenylalanine - a maximum of 233 mg of phenylalanine per treatment.
  • Ask patients to inform you if they have trouble swallowing or are prone to regurgitation or aspiration.
  • Instruct patients that each pouch needs to be diluted in water before ingestion and that they need to drink additional clear liquid (e.g., water, clear soup, fruit juice without pulp, soft drinks, tea and/or coffee without milk) according to instructions.
  • Inform patients that oral medications may not be absorbed properly if they are taken within one hour of starting each dose of MoviPrep.
  • Tell patients not to take other laxatives while they are taking MoviPrep.
  • Tell patients that MoviPrep produces a watery stool (diarrhea) which cleanses the colon before colonoscopy. Advise patients receiving MoviPrep to adequately hydrate before, during, and after the use of MoviPrep. Patients may have clear soup and/or plain yogurt for dinner, finishing the evening meal at least one hour prior to the start of MoviPrep treatment. No solid food should be taken from the start of MoviPrep treatment until after the colonoscopy.
  • Tell patients that the first bowel movement may occur approximately 1 hour after the start of MoviPrep administration. Abdominal bloating and distention may occur before the first bowel movement. If severe abdominal discomfort or distention occurs, stop drinking MoviPrep temporarily or drink each portion at longer intervals until these symptoms diminish. If severe symptoms persist, notify your health provider.

Nonclinical Toxicology

Carcinogenesis, Mutagenesis, Impairment of Fertility

Long-term studies in animals to evaluate the carcinogenic potential have not been performed with MoviPrep. Studies to evaluate potential for impairment of fertility or mutagenic potential have not been performed with MoviPrep.

Use In Specific Populations

Pregnancy

Pregnancy Category C. Animal reproduction studies have not been performed with MoviPrep. It is also not known if MoviPrep can cause fetal harm when administered to a pregnant woman or can affect reproductive capacity. MoviPrep should be given to a pregnant woman only if clearly needed.

Nursing Mothers

It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when MoviPrep is administered to a nursing woman.

Pediatric Use

The safety and effectiveness of MoviPrep in pediatric patients has not been established.

Geriatric Use

Of the 413 patients in clinical studies receiving MoviPrep, 91 (22%) patients were aged 65 or older, while 25 (6%) patients were over 75 years of age. No overall differences in safety or effectiveness were observed between geriatric patients and younger patients, and other reported clinical experience has not identified differences in responses between geriatric patients and younger patients, but greater sensitivity of some older individuals cannot be ruled out.

Last reviewed on RxList: 10/5/2012
This monograph has been modified to include the generic and brand name in many instances.

OVERDOSE

There have been no reported cases of overdose with MoviPrep. Purposeful or gross accidental ingestion of more than the recommended dose of MoviPrep might be expected to lead to severe electrolyte disturbances, including hyponatremia and/or hypokalemia, as well as dehydration and hypovolemia, with signs and symptoms of these disturbances. The patient who has taken an overdose should be monitored carefully, and treated symptomatically for complications.

CONTRAINDICATIONS

MoviPrep is contraindicated in the following conditions:

  • Gastrointestinal (Gl) obstruction
  • Bowel perforation
  • Gastric retention
  • Ileus
  • Toxic colitis or toxic megacolon
  • Hypersensitivity to any components of MoviPrep [see DESCRIPTION]

Last reviewed on RxList: 10/5/2012
This monograph has been modified to include the generic and brand name in many instances.

CLINICAL PHARMACOLOGY

Mechanism of Action

The primary mode of action is thought to be through the osmotic effect of polyethylene glycol 3350, sodium sulfate, sodium chloride, potassium chloride, sodium ascorbate, and ascorbic acid, which causes water to be retained in the colon and produces a watery stool.

Pharmacokinetics

The pharmacokinetics of MoviPrep have not been studied in patients with renal or hepatic insufficiency.

Clinical Studies

The colon cleansing efficacy and safety of MoviPrep was evaluated in two randomized, actively-controlled, multi-center, investigator-blinded, phase 3 trials in patients scheduled to have an elective colonoscopy.

In the first study, patients were randomized to one of the following two colon preparation treatments: 1) 2 liters of MoviPrep with 1 additional liter of clear liquid split into two doses (during the evening before and the morning of the colonoscopy) and 2) 4 liters of polyethylene glycol plus electrolytes solution (4L PEG + E) split into two doses (during the evening before and the morning of the colonoscopy). Patients were allowed to have a morning breakfast, a light lunch, clear soup and/or plain yogurt for dinner. Dinner had to be completed at least one hour prior to initiation of the colon preparation administration.

The primary efficacy endpoint was the proportion of patients with effective colon cleansing as judged by blinded gastroenterologists on the basis of videotapes recorded during the colonoscopy.

The blinded gastroenterologists graded the colon cleansing twice (during introduction and withdrawal of the colonoscope) and the poorer of the two assessments was used in the primary efficacy analysis.

The efficacy analysis included 308 adult patients who had an elective colonoscopy. Patients ranged in age from 18 to 88 years old (mean age about 59 years old) with 52% female and 48% male patients. Table 3 displays the results.

Table 3: Effectiveness of Overall Colon Cleansing in the Study of MoviPrep vs 4 Liter Polyethylene Glycol plus Electrolytes Solution

  Responders A2 or B3 (%) C4 (%) D5 (%)
MoviPrep® (N=153) 88.9 9.8 1.3
4L PEG + E1 (N=155) 94.8 4.5 0.6
1 4L PEG + E is 4 Liter Polyethylene Glycol plus Electrolytes Solution
2 A: colon empty and clean or presence of clear liquid, but easily removed by suction
3 B: brown liquid or semisolid remaining amounts of stool, fully removable by suction or displaceable, thus allowing a complete visualization of the gut mucosa
4 C: semisolid amounts of stool, only partially removable with a risk of incomplete visualization of the gut mucosa
5 D: semisolid or solid amounts of stool; consequently colonoscopy incomplete or needed to be terminated.

4 L PEG+E's responder rate was not significantly higher than MoviPrep's responder rate.

In the second study, patients were randomized to one of the following two colon preparation treatments: 1) 2 liters of MoviPrep with 1 additional liter of clear liquid in the evening prior to the colonoscopy and 2) 90 mL of oral sodium phosphate solution (90 mL OSPS) with at least 2 liters of additional clear liquid during the day and evening prior to the colonoscopy. Patients randomized to MoviPrep therapy were allowed to have a morning breakfast; a light lunch; and clear soup and/or plain yogurt for dinner. Dinner had to be completed at least one hour prior to initiation of the colon preparation administration.

The primary efficacy endpoint was the proportion of patients with effective colon cleansing as judged by the colonoscopist and one blinded gastroenterologist (on the basis of videotapes recorded during the colonoscopy). In case of a discrepancy between the colonoscopist and the blinded gastroenterologist, a second blinded gastroenterologist made the final efficacy determination.

The efficacy analysis included 280 adult patients who had an elective colonoscopy. Patients ranged in age from 21 to 76 years old (mean age about 53 years old) with 47% female and 53% male patients. Table 4 displays the results.

Table 4: Effectiveness of Overall Colon Cleansing in the Study of MoviPrep vs 90mL Oral Sodium Phosphate Solution

  Responders A2 or B3 (%) C4 (%) D5 (%)
MoviPrep® (N=137) 73.0 23.4 3.6
90 mL OSPS1 (N=143) 64.4 29.4 6.3
1 OSPS is Oral Sodium Phosphate Solution
2 A: empty and clean or clear liquid (transparent, yellow, or green)
3 B: brown liquid or semisolid remaining small amounts of stool, fully removable by suction or displaceable allowing a complete visualization of the underlying mucosa
4 C: semi solid only partially removable/displaceable stools; risk of incomplete examination of the underlying mucosa
5 D: heavy and hard stool making the segment examination uninterpretable and, consequently, the colonoscopy needed to be terminated

MoviPrep's responder rate was not significantly higher than OSPS's responder rate.

Last reviewed on RxList: 10/5/2012
This monograph has been modified to include the generic and brand name in many instances.

PATIENT INFORMATION

MoviPrep®
(moo-vee-prep) (polyethylene glycol (PEG) 3350, sodium sulfate, sodium chloride, potassium chloride, sodium ascorbate, and ascorbic acid) Oral Solution

Read this Medication Guide before you start taking MoviPrep and each time you get a new prescription. There may be new information. This Medication Guide does not take the place of talking with your healthcare provider about your medical condition or your treatment.

What is the most important information I should know about MoviPrep?

MoviPrep can cause serious side effects, including:

Serious loss of body fluid (dehydration) and changes in blood salts (electrolytes) in your blood.

These changes can cause:

  • abnormal heartbeats that can cause death
  • seizures. This can happen even if you have never had a seizure.
  • kidney problems

Your chance of having fluid loss and changes in body salts with MoviPrep is higher if you:

  • have heart problems
  • have kidney problems
  • take water pills (diuretics), high blood pressure medication, or non-steroidal anti-inflammatory drugs (NSAIDS)

Tell your healthcare provider right away if you have any of these symptoms of a loss of too much body fluid (dehydration) while taking MoviPrep:

See “What are the possible side effects of MoviPrep?” for more information about side effects.

What is MoviPrep?

MoviPrep is a prescription medicine used by adults 18 years and older to clean the colon before a colonoscopy. MoviPrep cleans your colon by causing you to have diarrhea. Cleaning your colon helps your healthcare provider see the inside of your colon more clearly during your colonoscopy.

It is not known if MoviPrep is safe and effective in children.

Who should not take MoviPrep?

Do not take MoviPrep if your healthcare provider has told you that you have:

  • a blockage in your bowel (obstruction)
  • an opening in the wall of your stomach or intestine (bowel perforation)
  • problems with food and fluid emptying from your stomach (gastric retention)
  • a very dilated intestine (bowel)
  • an allergy to any of the ingredients in MoviPrep. See the end of this leaflet for a complete list of ingredients in MoviPrep.

What should I tell my healthcare provider before taking MoviPrep?

Before you take MoviPrep, tell your healthcare provider if you:

  • have heart problems
  • have a history of seizures
  • have kidney problems
  • have stomach or bowel problems, including ulcerative colitis
  • have problems with swallowing or gastric reflux
  • have a condition that destroys red blood cells called Glucose-6-phosphate dehydrogenase (G6PD) deficiency
  • are withdrawing from drinking alcohol
  • have a low blood salt (sodium) level (hyponatremia)
  • are on a diet low in phenylalanine
  • have any other medical conditions
  • are pregnant. It is not known if MoviPrep will harm your unborn baby. Talk to your healthcare provider if you are pregnant or plan to become pregnant.
  • are breastfeeding or plan to breast-feed. It is not known if MoviPrep passes into your breast milk. You and your healthcare provider should decide if you will take MoviPrep while breastfeeding.

Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

MoviPrep may affect how other medicines work. Medicines taken by mouth may not be absorbed properly when taken within 1 hour before the start of MoviPrep.

Especially tell your healthcare provider if you take:

  • medicines for blood pressure or heart problems
  • medicines for kidney problems
  • medicines for seizures
  • water pills (diuretics)
  • non-steroidal anti-inflammatory medicines (NSAID); pain medicines
  • laxatives

Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure if you are taking any of the medicines listed above.

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

How should I take MoviPrep?

See the Patient Instructions on the outer product carton for dosing instructions. You must read, understand, and follow these instructions to take MoviPrep the right way.

  • Take MoviPrep exactly as your healthcare provider tells you to take it.
  • It is important for you to drink the additional prescribed amount of clear liquid (e.g. water, clear soup, fruit juice without pulp, soft drinks, tea and/or coffee without milk) listed in the Patient Instructions to prevent fluid loss (dehydration).
  • Do not take MoviPrep that has not been mixed with water (diluted).
  • Do not take other laxatives while taking MoviPrep.
  • Do not eat solid foods while taking MoviPrep. Only clear liquids are allowed while taking and after taking MoviPrep until your colonoscopy.
  • Stop drinking MoviPrep solution temporarily or allow for longer time between each dose if you have stomach discomfort, pain or bloating until your symptoms improve. If symptoms continue, tell your healthcare provider.
  • If you take too much MoviPrep, call your healthcare provider or get medical help right away.

What are the possible side effects of MoviPrep?

MoviPrep can cause serious side effects, including:

  • See Section “What is the most important information I should know about MoviPrep?”
  • Changes in certain blood tests. Your healthcare provider may do blood tests after you take MoviPrep to check your blood for changes. Tell your healthcare provider if you have any symptoms of too much fluid loss, including:
  • Heart problems (arrhythmias). MoviPrep may cause irregular heartbeats.
  • Seizures or fainting (black-outs)
  • Ulcers of the bowel or bowel problems

The most common side effects of MoviPrep for split dosing include:

  • malaise
  • nausea
  • stomach (abdominal) pain
  • vomiting, bloating

The most common side effects of MoviPrep for evening-only full dosing include:

  • stomach swelling (abdominal distention)
  • anal discomfort
  • thirst
  • nausea
  • stomach (abdominal) pain
  • sleep disorder
  • rigors
  • hunger
  • malaise
  • vomiting
  • dizziness

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of MoviPrep. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store MoviPrep?

  • Store MoviPrep between 59°F to 86°F (15°C to 30°C).
  • MoviPrep solution that has been mixed with water may be refrigerated. Mixed solution should be taken within 24 hours.

Keep MoviPrep and all medicines out of the reach of children.

General information about the safe and effective use of MoviPrep.

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use MoviPrep for a condition for which it was not prescribed. Do not give MoviPrep to other people, even if they are going to have the same procedure you are. It may harm them.

This Medication Guide summarizes the most important information about MoviPrep. If you would like more information, talk with your healthcare provider or pharmacist. You can ask your pharmacist or healthcare provider for information that is written for healthcare professionals.

For more information, call 1-866-669-7597 or go to www.MoviPrep.com.

What are the ingredients in MoviPrep?

Active ingredients:

Pouch A: polyethylene glycol (PEG) 3350, sodium sulfate, sodium chloride, potassium chloride.

Pouch B: ascorbic acid and sodium ascorbate.

Inactive ingredients:

Pouch A: aspartame, acesulfame potassium, and lemon flavor.

This Medication Guide has been approved by the U.S. Food and Drug Administration.

Last reviewed on RxList: 10/5/2012
This monograph has been modified to include the generic and brand name in many instances.

>

PATIENT INFORMATION

MoviPrep®
(moo-vee-prep) (polyethylene glycol (PEG) 3350, sodium sulfate, sodium chloride, potassium chloride, sodium ascorbate, and ascorbic acid) Oral Solution

Read this Medication Guide before you start taking MoviPrep and each time you get a new prescription. There may be new information. This Medication Guide does not take the place of talking with your healthcare provider about your medical condition or your treatment.

What is the most important information I should know about MoviPrep?

MoviPrep can cause serious side effects, including:

Serious loss of body fluid (dehydration) and changes in blood salts (electrolytes) in your blood.

These changes can cause:

  • abnormal heartbeats that can cause death
  • seizures. This can happen even if you have never had a seizure.
  • kidney problems

Your chance of having fluid loss and changes in body salts with MoviPrep is higher if you:

  • have heart problems
  • have kidney problems
  • take water pills (diuretics), high blood pressure medication, or non-steroidal anti-inflammatory drugs (NSAIDS)

Tell your healthcare provider right away if you have any of these symptoms of a loss of too much body fluid (dehydration) while taking MoviPrep:

See “What are the possible side effects of MoviPrep?” for more information about side effects.

What is MoviPrep?

MoviPrep is a prescription medicine used by adults 18 years and older to clean the colon before a colonoscopy. MoviPrep cleans your colon by causing you to have diarrhea. Cleaning your colon helps your healthcare provider see the inside of your colon more clearly during your colonoscopy.

It is not known if MoviPrep is safe and effective in children.

Who should not take MoviPrep?

Do not take MoviPrep if your healthcare provider has told you that you have:

  • a blockage in your bowel (obstruction)
  • an opening in the wall of your stomach or intestine (bowel perforation)
  • problems with food and fluid emptying from your stomach (gastric retention)
  • a very dilated intestine (bowel)
  • an allergy to any of the ingredients in MoviPrep. See the end of this leaflet for a complete list of ingredients in MoviPrep.

What should I tell my healthcare provider before taking MoviPrep?

Before you take MoviPrep, tell your healthcare provider if you:

  • have heart problems
  • have a history of seizures
  • have kidney problems
  • have stomach or bowel problems, including ulcerative colitis
  • have problems with swallowing or gastric reflux
  • have a condition that destroys red blood cells called Glucose-6-phosphate dehydrogenase (G6PD) deficiency
  • are withdrawing from drinking alcohol
  • have a low blood salt (sodium) level (hyponatremia)
  • are on a diet low in phenylalanine
  • have any other medical conditions
  • are pregnant. It is not known if MoviPrep will harm your unborn baby. Talk to your healthcare provider if you are pregnant or plan to become pregnant.
  • are breastfeeding or plan to breast-feed. It is not known if MoviPrep passes into your breast milk. You and your healthcare provider should decide if you will take MoviPrep while breastfeeding.

Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

MoviPrep may affect how other medicines work. Medicines taken by mouth may not be absorbed properly when taken within 1 hour before the start of MoviPrep.

Especially tell your healthcare provider if you take:

  • medicines for blood pressure or heart problems
  • medicines for kidney problems
  • medicines for seizures
  • water pills (diuretics)
  • non-steroidal anti-inflammatory medicines (NSAID); pain medicines
  • laxatives

Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure if you are taking any of the medicines listed above.

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

How should I take MoviPrep?

See the Patient Instructions on the outer product carton for dosing instructions. You must read, understand, and follow these instructions to take MoviPrep the right way.

  • Take MoviPrep exactly as your healthcare provider tells you to take it.
  • It is important for you to drink the additional prescribed amount of clear liquid (e.g. water, clear soup, fruit juice without pulp, soft drinks, tea and/or coffee without milk) listed in the Patient Instructions to prevent fluid loss (dehydration).
  • Do not take MoviPrep that has not been mixed with water (diluted).
  • Do not take other laxatives while taking MoviPrep.
  • Do not eat solid foods while taking MoviPrep. Only clear liquids are allowed while taking and after taking MoviPrep until your colonoscopy.
  • Stop drinking MoviPrep solution temporarily or allow for longer time between each dose if you have stomach discomfort, pain or bloating until your symptoms improve. If symptoms continue, tell your healthcare provider.
  • If you take too much MoviPrep, call your healthcare provider or get medical help right away.

What are the possible side effects of MoviPrep?

MoviPrep can cause serious side effects, including:

  • See Section “What is the most important information I should know about MoviPrep?”
  • Changes in certain blood tests. Your healthcare provider may do blood tests after you take MoviPrep to check your blood for changes. Tell your healthcare provider if you have any symptoms of too much fluid loss, including:
  • Heart problems (arrhythmias). MoviPrep may cause irregular heartbeats.
  • Seizures or fainting (black-outs)
  • Ulcers of the bowel or bowel problems

The most common side effects of MoviPrep for split dosing include:

  • malaise
  • nausea
  • stomach (abdominal) pain
  • vomiting, bloating

The most common side effects of MoviPrep for evening-only full dosing include:

  • stomach swelling (abdominal distention)
  • anal discomfort
  • thirst
  • nausea
  • stomach (abdominal) pain
  • sleep disorder
  • rigors
  • hunger
  • malaise
  • vomiting
  • dizziness

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of MoviPrep. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store MoviPrep?

  • Store MoviPrep between 59°F to 86°F (15°C to 30°C).
  • MoviPrep solution that has been mixed with water may be refrigerated. Mixed solution should be taken within 24 hours.

Keep MoviPrep and all medicines out of the reach of children.

General information about the safe and effective use of MoviPrep.

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use MoviPrep for a condition for which it was not prescribed. Do not give MoviPrep to other people, even if they are going to have the same procedure you are. It may harm them.

This Medication Guide summarizes the most important information about MoviPrep. If you would like more information, talk with your healthcare provider or pharmacist. You can ask your pharmacist or healthcare provider for information that is written for healthcare professionals.

For more information, call 1-866-669-7597 or go to www.MoviPrep.com.

What are the ingredients in MoviPrep?

Active ingredients:

Pouch A: polyethylene glycol (PEG) 3350, sodium sulfate, sodium chloride, potassium chloride.

Pouch B: ascorbic acid and sodium ascorbate.

Inactive ingredients:

Pouch A: aspartame, acesulfame potassium, and lemon flavor.

This Medication Guide has been approved by the U.S. Food and Drug Administration.

Last reviewed on RxList: 10/5/2012
This monograph has been modified to include the generic and brand name in many instances.

Disclaimer

MoviPrep Consumer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

PEG/ELECTROLYTE 2 LITERS - ORAL

(PEG/ih-LECK-troh-lite)

COMMON BRAND NAME(S): MoviPrep

USES: PEG (polyethylene glycol) with electrolyte is used to clean out the intestines before certain bowel exam procedures such as colonoscopy or barium enema X-rays. It is a laxative that works by drawing large amounts of water into the colon. This effect results in watery bowel movements. Clearing stool from the intestines helps your doctor to better examine the intestines during your procedure.

HOW TO USE: Read the Medication Guide provided by your pharmacist before you start taking this medication and each time you get a new prescription for it. If you have any questions, ask your doctor or pharmacist.

Follow any special diet instructions provided by your doctor. Be sure to ask your doctor about acceptable foods/liquids you may eat or drink before the procedure; otherwise the exam may have to be repeated. Finish your evening meal at least 1 hour before starting this medication. After you start drinking this medication, do not eat any solid food until after your procedure is done. To prevent losing too much body water (becoming dehydrated), drink plenty of clear liquids as directed by your doctor.

Before using this product, mix it as directed. Read and follow all directions provided by the manufacturer to mix this product. After mixing, you may place the container in the refrigerator until ready to drink. Chilling the mixed liquid may improve its taste.

Take this product by mouth without food or as directed by your doctor. Dosage is based on your age and medical condition.

The night before your procedure, quickly drink one 8-ounce glass (240 milliliters) of the mixture every 15 minutes until you finish the first container (1 liter), or take as directed by your doctor. After drinking the first liter of the prepared solution, drink 2 glasses (480 milliliters/2 cups/16 ounces) of water or other clear liquid. Drink the second liter of prepared solution either the night before your procedure (one-and-a-half hours after the first liter) or on the morning of your procedure as directed by your doctor. After drinking the second liter of prepared solution, drink 2 more glasses (480 milliliters/2 cups/16 ounces) of water or other clear liquid.

It is best to drink the mixed liquid quickly instead of sipping slowly. Ask your doctor or pharmacist if you have any questions about how to mix or take this product or what to expect after taking this product.

Watery bowel movements usually begin about 1 hour after you start to drink the mixed liquid. The bowel movements can be very large and watery.

Do not take any other medications by mouth within 1 hour of starting to drink the mixed liquid because your body may not absorb the other medications. Ask your doctor or pharmacist if you are not sure when to take your other medications.

Disclaimer

MoviPrep Consumer (continued)

SIDE EFFECTS: Very watery bowel movements are expected with this medication. Nausea, bloating, or feelings of fullness in the stomach/abdomen are very common. Stomach/abdominal cramps, vomiting, and anal irritation occur less often. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

If severe bloating or abdominal pain occurs, drink the mixture more slowly or temporarily stop drinking the mixture until the symptoms improve.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these rare but very serious side effects occur: vomit that is bloody or looks like coffee grounds, chest pain, fast/slow/irregular heartbeat, dizziness, fainting, seizures, sudden shortness of breath, unusual change in the amount of urine.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the MoviPrep (peg-3350, sodium sulfate, sodium chloride, potassium chloride, sodium ascorbate, ascorbic acid) Side Effects Center for a complete guide to possible side effects »

PRECAUTIONS: Before taking PEG with electrolyte, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: blocked intestines (gastrointestinal obstruction), hole in the intestines, severe infection in the intestines (such as toxic colitis, toxic megacolon).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: severe ulcers/swelling of the colon (ulcerative colitis), intestines that are not moving (ileus), problems with the normal urge to close the throat when the back of the mouth/throat is touched (poor gag reflex), history of vomiting easily/often, history of breathing food/other substances into the lungs, certain metabolic problem (G6PD deficiency), kidney problems, heart problems (such as irregular heartbeat).

Special caution should be taken if this medication is given to an unconscious or partly conscious person.

This medicine may contain aspartame. If you have phenylketonuria (PKU) or any other condition that requires you to restrict your intake of aspartame (or phenylalanine), consult your doctor or pharmacist about using this drug safely.

Caution is advised when using this drug in the elderly because they may be more sensitive to its effects, especially dehydration and loss of salts in the blood (such as potassium, sodium).

Caution is advised when using this drug in children because they may be more sensitive to its effects, especially dehydration and loss of salts in the blood (such as potassium, sodium).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

Disclaimer

MoviPrep Consumer (continued)

DRUG INTERACTIONS: See also How to Use section.

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially drugs that can change the amount of water, sodium, or potassium in your body such as: "water pills" such as thiazide diuretics, some heart/blood pressure medications called ACE inhibitors (such as captopril, enalapril).

Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center.

NOTES: Do not share this medication with others.

Laboratory tests (such as sodium, potassium levels) may be performed before or after taking this medication to check for side effects. Consult your doctor for more details.

MISSED DOSE: Not applicable.

STORAGE: Store the unmixed powder at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Do not store in the bathroom. After mixing the solution, you may store it in the refrigerator. Use within 24 hours after mixing. Discard any unused mixture. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised March 2012. Copyright(c) 2012 First Databank, Inc.

MoviPrep Patient Information Including Side Effects

Brand Names: Colyte, Colyte with Flavor Packs, GoLYTELY, MoviPrep, NuLYTELY, NuLYTELY Cherry, NuLYTELY Lemon Lime, NuLYTELY Orange, NuLYTELY with Flavor Packs, PEG-3350 with Electolytes, TriLyte with Flavor Packs

Generic Name: polyethylene glycol electrolyte solution (Pronunciation: pall ee ETH il een GLYE kol ee LEK troe lyte)

What is polyethylene glycol electrolyte solution (MoviPrep)?

Polyethylene glycol electrolyte solution is a laxative solution that increases the amount of water in the intestinal tract to stimulate bowel movements. This medication also contains potassium, sodium, and other minerals to replace electrolytes that are passed from the body in the stool.

Polyethylene glycol electrolyte solution is used to clean the bowel before colonoscopy, a barium x-ray, or other intestinal procedures.

Polyethylene glycol electrolyte solution may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of polyethylene glycol electrolyte solution?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor if you have any of these serious side effects:

  • severe stomach pain or bloating;
  • no bowel movement within 2 hours after use; or
  • gagging, choking, or vomiting.

If you have any of these side effects, you may need to drink the medication more slowly, or stop using it for a short time.

Less serious side effects may include:

  • mild stomach cramps, gas, or bloating;
  • rectal pain or irritation;
  • nausea; or
  • passing gas.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Read the MoviPrep (peg-3350, sodium sulfate, sodium chloride, potassium chloride, sodium ascorbate, ascorbic acid) Side Effects Center for a complete guide to possible side effects »

What is the most important information I should know about polyethylene glycol electrolyte solution?

Do not use this medication if you are allergic to polyethylene glycol or any other electrolyte solutions (such as Pedialyte or Gatorade).

You should also not take polyethylene glycol electrolyte solution if you have a perforated bowel, a bowel obstruction or severe constipation, or colitis or toxic megacolon. If you have any these conditions, you could have dangerous or life-threatening side effects from polyethylene glycol electrolyte solution.

People with eating disorders (such as anorexia or bulimia) should not take polyethylene glycol electrolyte solution without the advice of a doctor.

Talk to your healthcare provider if you are not able to consume all of the solution. Incomplete cleansing of the bowel may affect the scheduled procedure.

Side Effects Centers

MoviPrep Patient Information including How Should I Take

What should I discuss with my health care provider before taking polyethylene glycol electrolyte solution?

Do not use this medication if you are allergic to polyethylene glycol or any other electrolyte solutions (such as Pedialyte or Gatorade), or if you have:

  • a perforated bowel;
  • a bowel obstruction or severe constipation; or
  • colitis or toxic megacolon.

If you have any these conditions, you could have dangerous or life-threatening side effects from polyethylene glycol electrolyte solution.

People with eating disorders (such as anorexia or bulimia) should not use this medication without the advice of a doctor.

Before taking polyethylene glycol electrolyte solution, tell your doctor if you are allergic to any drugs, or if you have:

  • nausea or vomiting;
  • trouble swallowing; or
  • a history of bowel obstruction, diverticulitis, ulcerative colitis, or other chronic bowel disease.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take polyethylene glycol electrolyte solution.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether polyethylene glycol electrolyte solution passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Older adults may be more likely to have serious side effects from this medicine.

How should I take polyethylene glycol electrolyte solution?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Do not take polyethylene glycol electrolyte solution if it has been less than 2 hours since you last ate solid food. For best results, take the medicine 3 to 4 hours after you last ate.

Do not add any flavorings to this medicine, such as sugar, honey, artificial sweetener, fruit juices, or other beverages.

Chilling the medicine in a refrigerator may make it taste better.

Shake the liquid well just before you measure a dose. Drink this medicine in the exact portions at the exact time intervals prescribed by your doctor.

Polyethylene glycol electrolyte solution will produce watery diarrhea. Keep taking the medicine until your stool is watery and clear. In most cases, at least 3 liters of polyethylene glycol electrolyte solution is needed for the full effect.

The usual dose of the medication is 8 ounces every 10 minutes. Drink each portion as quickly as possible, rather than sipping it slowly. The first watery stool should appear within 1 hour after you start drinking polyethylene glycol electrolyte solution.

You may be instructed not to drink or eat anything before your medical test or procedure. Follow your doctor's instructions about the type and amount of liquids you should drink for at least 24 hours before and after your test or procedure.

Throw away any polyethylene glycol electrolyte solution you have not used within 48 hours after it was mixed.

Side Effects Centers

MoviPrep Patient Information including If I Miss a Dose

What happens if I miss a dose?

Talk to your doctor if you cannot drink all of the medication prescribed for you. Your test or procedure may need to be rescheduled if your bowel is not completely cleansed.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine at one time.

An overdose of this medication is not expected to produce life-threatening symptoms.

What should I avoid while taking polyethylene glycol electrolyte solution?

Avoid taking other medications, vitamins, or mineral supplements within 1 hour before drinking polyethylene glycol electrolyte solution. Any medications you take just before a bowel cleansing will not be properly absorbed into your body.

Do not use other laxatives while using polyethylene glycol electrolyte solution unless your doctor has told you to.

What other drugs will affect polyethylene glycol electrolyte solution?

There may be other drugs that can interact with polyethylene glycol electrolyte solution. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about polyethylene glycol electrolyte solution.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 2.03. Revision date: 12/15/2010.

Your use of the content provided in this service indicates that you have read,understood and agree to the End-User License Agreement,which can be accessed by clicking on this link.

Healthwise

Side Effects Centers

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