کلرپرومازین
Chlorpromazine (Thorazine)
کلرپرومازین

نام ژنریک

Chlorpromazine

شکل دارویی

اشكال دارويي:


Tablet: 25,100mg


Injection: 25 mg/ml, 2ml

موارد مصرف

موارد و مقدار مصرف


الف)‌ سايكوز.


بزرگسالان بستري: براي بيماران با مشكلات حاد يا مانيك 25 ميلي گرم عضلاني تزريق مي‌ شود. در صورت لزوم 25 تا 50 ميلي گرم عضلاني به فاصله 1 ساعت تزريق شود. دوز عضلاني را مي‌ توان به تدريج در مدت چند روز افزايش داد تا به 400 ميلي گرم هر 4 تا 6 ساعت برسد. در شرايط مناسب مي‌ توان دوز خوراكي را جايگزين آن كرد. 500 ميلي گرم خوراكي روزانه تا 1000 ميلي گرم معمولاً كافي مي‌باشد ، اما اين دوز تا 2000 ميلي گرم در روز نيز قابل افزايش مي‌ باشد. براي بيماران با علائم خفيف تر مي‌ توان دارو را 25 ميلي گرم خوراكي، سه بار در روز شروع كرد و به دوز مؤثر ( معمولاً 400 ميلي گرم در روز ) رساند.


بزرگسالان سرپايي: 10 ميلي گرم خوراكي 3-2 بار يا 25 ميلي گرم 2 تا 3 بار در روز. در موارد شديدتر به صورت 25 ميلي گرم سه بار در روز استفاده مي‌ شود. بعد از يك تا دو روز، دوز دارو ممكن است 20 تا 50 ميلي گرم روزانه به فاصله دوبار در هفته افزايش پيدا كند.


كودكان 6 ماه و بزرگتر: mg/kg 5/0 خوراكي هر 4 تا 6 ساعت يا عضلاني هر 6 تا 8 ساعت يا mg/kg 1 ركتال هر 6 تا 8 ساعت. حداكثر دوز عضلاني در كودكان كمتر از 5 سال يا وزن كمتر از 23 كيلوگرم ، 40 ميلي گرم و در كودكان 12-5 ساله يا وزن 45-23 كيلوگرم، 75 ميلي گرم مي‌ باشد.


ب) تهوع و استفراغ.


بزرگسالان: 10-25 ميلي گرم خوراكي هر 4 تا 6 ساعت در صورت لزوم يا 50 تا 100 ميلي گرم ركتال هر 6 تا 8 ساعت در صورت لزوم يا 25 ميلي گرم عضلاني در ابتداي مصرف چنانچه بيمار دچار افت فشار خون نشود، ‌25 تا 50 ميلي گرم عضلاني هر 3 تا 4 ساعت در صورت لزوم، تا هنگامي كه استفراغ متوقف شود، تزريق مي‌ شود.


كودكان 6 ماه و بزرگتر : mg/kg 55/0 خوراكي هر 4 تا 6 ساعت در صورت لزوم يا هر 6 تا 8 ساعت عضلاني در صورت لزوم يا mg/kg 1/1 ركتال هر 6 تا 8 ساعت در صورت لزوم. حداكثر دوز عضلاني در كودكان زير 5 سال يا وزن كمتر از 23 كيلوگرم ، 40 ميلي گرم و در كودكان 5 تا 12 ساله يا وزن
23 تا 45 كيلوگرم، 75 ميلي گرم مي‌ باشد.


پ) سكسكه‌هاي شديد، پورفيري حاد متناوب.


بزرگسالان: 25 تا 50 ميلي گرم خوراكي يا عضلاني، ‌3 تا 4 مرتبه در روز.


چنانچه سكسكه ادامه پيدا كند، 25 تا 50 ميلي گرم از دارو در 500 تا 1000 ميلي ليتر از نرمال سالين رقيق شده و در بيمار دراز كشيده به آهستگي انفوزيون وريدي مي‌ شود.


ت) كزاز.


بزرگسالان : 25 تا 50 ميلي گرم عضلاني يا وريدي 3 تا 4 بار در روز.


كودكان 6 ماه و بزرگتر: ‌ mg/kg 5/0 عضلاني يا وريدي هر 6 تا 8 ساعت حداكثر مقدار تزريقي در كودكان با وزن كمتر از 23 ميلي گرم، 40 ميلي گرم روزانه و در كودكان با وزن 23 تا 45 كيلوگرم، 75 ميلي گرم روزانه (به جز در موارد شديد) مي‌باشد.


ث) جراحي.


بزرگسالان: مقدار 25 تا 50 ميلي گرم خوراكي 2 تا 3 ساعت يا 5/12 تا 25 ميلي گرم عضلاني 1 تا 2 ساعت قبل از جراحي تجويز مي‌ شود. در طول جراحي، در صورت لزوم 5/12 ميلي گرم عضلاني در مدت 30 دقيقه تكرار شده يا به صورت 2 ميلي گرم وريدي با فواصل 2 دقيقه تا حداكثر 25 ميلي گرم تزريق مي‌ شود. پس از جراحي، ‌10 تا 25 ميلي گرم خوراكي هر 4 تا 6 ساعت يا 5/12 تا 25 ميلي گرم عضلاني كه در صورت لزوم در مدت 1 ساعت قابل تكرار مي‌ باشد، تزريق مي‌ شود.


كودكان 6 ماه و بزرگتر: mg/kg 5/0 خوراكي 2 تا 3 ساعت قبل از جراحي يا عضلاني 1 تا 2 ساعت قبل از جراحي مصرف مي‌ شود. در حين جراحي: mg/kg 25/0 عضلاني كه در صورت لزوم در مدت 30 دقيقه تكرار مي‌ شود، يا دوزهاي 1 ميلي گرم در فواصل 2 دقيقه كه به صورت وريدي
تزريق مي‌ شود و حداكثر دوز آن mg/kg 25/0 مي‌ باشد. پس از جراحي: mg/kg 55/0 خوراكي يا عضلاني دوز خوراكي هر 4 تا 6 ساعت يا دوز عضلاني در مدت يك ساعت تكرار مي‌ شود (در صورت لزوم و چنانچه بيمار دچار افت فشار خون نشود).


تنظيم دوز: در افراد مسن، ضعيف و بيماران لاغر بهتر است دوز دارو كاهش داده شود.

موارد منع مصرف

موارد منع مصرف و احتياط


سلامت اين دارو در كودكان زير 6 ماه اثبات نشده است.


در بيماران با سابقه تشنج، تضعيف مغز استخوان، ‌يا بيماري شديد كبدي با احتياط مصرف شود.


هنگامي كه دارو به صورت تزريقي مصرف مي‌ شود، مي‌ تواند باعث افت فشار شود.


ديسكينزي ديررس: ميزان شروع آن در افراد مسن 40% مي‌ باشد. ايجاد اين سندرم با ماهيت برگشت ناپذير به مدت مصرف دارو و دوز تجمعي آن بستگي دارد و چنانچه زود تشخيص داده شود قابل برگشت مي‌ باشد. واكنشهاي اكستراپيراميدال در افراد مسن شايعتر است و در سن بالاي 60 سال شيوع آن به بيش از 50% مي‌ رسد. پاركينسونيسم دارويي معمولاً اتفاق مي‌ افتد و آكاتيژيا شايعترين علامت اكستراپيراميدال در افراد مسن مي‌ باشد. گيجي، اختلال حافظه، رفتارهاي سايكوتيك و آژيتاسيون عموماً نتيجه اثرات آنتي كولينرژيك مي‌ باشد.


افت فشار وضعيتي به علت بلاك گيرنده آلفا اتفاق مي‌ افتد و افراد مسن در اين مورد در ريسك بالاتري قرار مي‌ گيرند.


رخوت ناشي از اين دارو در بيماراني كه سايكوتيك نيستند به علت ايجاد derealization depersonalization و dysphoria بسيار ناخوشايند است.


آريتمي‌هاي شديد وخطرناك حتي با دوزهاي درماني اين داروها نيز اتفاق مي‌ افتد.

عوارض جانبی دارو

عوارض جانبي


اعصاب مرکزي : نشانه‌هاي اکستراپيراميدال، ديسکينزي د يررس، رخوت، سودوپارکينسونيسم، خواب آلودگي، سندرم بدخيم نورولپتيک، تشنج.


قلبي ـ عروقي: کمي فشار خون وضع يتي، تاکيکاردي، تغييرات الکتروکارديوگرافي (EKG).


چشم، گوش، حلق و بيني: تاري د يد، تغييرات چشمي، احتقان بيني.


دستگاه گوارش: خشکي دهان ، يبوست، تهوع.


کبد: زردي.


ادراري ـ تناسلي: احتباس ادرار، مهار انزال، بي نظم ي قاعدگي، پرياپيسم.


خون: لکوپني گذرا ، آگرانولوسيتوز، ترومبوسيتوپني، آنمي آپلاستيک، ائوزينوفيلي، آنمي هموليتيک.


پوست: واکنش‌هاي آلرژيک حساسيت به نور خفيف، درد در محل تزريق عضلاني، پيگمانتاسيون پوست، آبسه استريل.


ساير عوارض: ژن يکوماستي.


قطع ناگهاني مصرف دارو بعد از درمان طولاني با کلرپرومازين ممکن است موجب بروز گاستريت، تهوع، استفراغ، سرگيجه، و ترمور شود.


مسموميت و درمان


تظاهرات باليني: تضعيف CNS که با علائم زير مشخص مي‌ شود:


خواب بسيار عميق و احتمالاً اغما ، کمي و يا زيادي فشار خون ، نشانه‌هاي اکستراپيراميدال، حرکت غيرطبيعي و غيرارادي عضلات ، آشفتگي، تشنج، اختلال ريتم قلب، تغييرات الکتروکارديوگرام (EKG)، افزايش يا کاهش حرارت بدن و اختلال عملکرد سيستم اعصاب خودکار.


درمان: شامل درمان علائم ظاهرشده و اقدامات حمايتي، مانند حفظ علائم حياتي، باز نگه داشتن راه تنفسي، ثابت نگه داشتن حرارت بدن، و حفظ تعادل آب و الکتروليت مي‌ باشد.


القاي استفراغ نبايد صورت گيرد، زيرا کلرپرومازين از رفلکس سرفه جلوگيري مي‌ کند و ممکن است آسپيراسيون صورت گيرد. معده را شستشو داده و بعد از آن از ذغال فعال و مسهل ‌هاي نمکي استفاده شود. دياليز مؤثر نيست. در صورت لزوم حرارت بدن تنظيم شود.


براي درمان کمي فشار خون از مايعات وريدي استفاده مي‌ شود و نبايد از اپي نفرين استفاده کرد. براي درمان تشنج از ديازپام و يا باربيتورات‌هاي تزريقي، درمان اختلال ريتم قلب از فني توئين تزريقي ( mg/kg 1 و سرعت تزريق بايد با فشار خون تنظيم گردد)، و درمان واکنش‌هاي اکستراپيراميدال، بنزتروپين، يا ديفن هيدرامين تزريقي mg 50-10 استفاده مي‌ شود.

موارد قابل توجه

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تداخل دارویی

تداخل دارويي


مصرف همزمان با داروهاي مقلد سمپاتيك، ممكن است اثرات تحريكي و بالا برنده فشار خون اين داروها را كاهش دهد. كلرپرومازين ممكن است اثرات اپي نفرين را معكوس كند از استفاده توام پرهيز شود.


كلرپرومازين ممكن است پاسخ فشار خون به داروهاي كاهنده فشار خون، ‌كه از طريق مركزي عمل مي‌ كنند، را در صورت مصرف همزمان، ‌تقويت كند.


مصرف همزمان با داروهاي مضعف CNS (مانند الكل ، ‌مسكنها، باربيتوراتها، مخدرها، آرام بخشها و داروهاي بيهوش كننده عمومي و نخاعي و يا بيحس كننده ‌هاي اپي دورال) موجب تشديد اثرات اين داروها مي‌ شود.


همچنين، مصرف همزمان اين دارو با سولفات منيزيم تزريقي موجب رخوت بيش از حد (oversedation)، ضعف تنفسي و كمي فشار خون مي‌ شود.


مصرف همزمان با داروهاي ضد آريتمي، كينيدين، ديسوپيراميد ‌و پروكائين آميد موجب افزايش بروز بي نظمي ريتم قلب و اختلالات هدايتي مي‌ شود. مصرف همزمان با داروهاي آنتي كولينرژيك، باعث افزايش اثرات آنتي كولينرژيك شده و علائم پاركينسون را تشديد مي‌ كند. با احتياط مصرف شود.


استفاده توام با مپريدين باعث افزايش رخوت و افت فشار خون مي‌ شود. بهتر است از استفاده توام پرهيز شود.


داروهاي مسدود كننده گيرنده بتا ممكن است با مهار متابوليسم کلرپرومازين، غلظت پلاسمايي و سميت اين دارو را افزايش دهند.


مصرف همزمان با پروپيل تيواوراسيل احتمال بروز آگرانولوسيتوز را افزايش مي‌ دهد. از استفاده همزمان پرهيز شود.


در صورت مصرف همزمان با ليتيم ممکن است مسموميت شديد نورولوژيک بروز کند و پاسخ درماني به کلرپرومازين کاهش يابد. از استفاده همزمان پرهيز شود.


کلرپرومازين مي‌ تواند اثر ضدانعقاد وارفارين را کاهش دهد. PT و INR چک شود.


کافئين مي‌ تواند فارماکوکينتيک دارو را تغيير داده و اثر درماني آن را کم کند. به بيماران توصيه کنيد از مصرف غذاها و نوشيدني‌هاي محتوي کافئين پرهيز کنند.


استفاده از الکل باعث افزايش دپرسيون سيستم اعصاب مرکزي، بويژه مهارتهاي سايکوموتور مي‌ شود.


سيگار کشيدن مي‌ تواند پاسخ به کلر پرومازين را کاهش دهد.


واکنشهاي حساسيت به نور مي‌ تواند به علت در معرض آفتاب قرار گرفتن اتفاق بيفتد.

مکانیزم اثر

تداخل دارويي


مصرف همزمان با داروهاي مقلد سمپاتيك، ممكن است اثرات تحريكي و بالا برنده فشار خون اين داروها را كاهش دهد. كلرپرومازين ممكن است اثرات اپي نفرين را معكوس كند از استفاده توام پرهيز شود.


كلرپرومازين ممكن است پاسخ فشار خون به داروهاي كاهنده فشار خون، ‌كه از طريق مركزي عمل مي‌ كنند، را در صورت مصرف همزمان، ‌تقويت كند.


مصرف همزمان با داروهاي مضعف CNS (مانند الكل ، ‌مسكنها، باربيتوراتها، مخدرها، آرام بخشها و داروهاي بيهوش كننده عمومي و نخاعي و يا بيحس كننده ‌هاي اپي دورال) موجب تشديد اثرات اين داروها مي‌ شود.


همچنين، مصرف همزمان اين دارو با سولفات منيزيم تزريقي موجب رخوت بيش از حد (oversedation)، ضعف تنفسي و كمي فشار خون مي‌ شود.


مصرف همزمان با داروهاي ضد آريتمي، كينيدين، ديسوپيراميد ‌و پروكائين آميد موجب افزايش بروز بي نظمي ريتم قلب و اختلالات هدايتي مي‌ شود. مصرف همزمان با داروهاي آنتي كولينرژيك، باعث افزايش اثرات آنتي كولينرژيك شده و علائم پاركينسون را تشديد مي‌ كند. با احتياط مصرف شود.


استفاده توام با مپريدين باعث افزايش رخوت و افت فشار خون مي‌ شود. بهتر است از استفاده توام پرهيز شود.


داروهاي مسدود كننده گيرنده بتا ممكن است با مهار متابوليسم کلرپرومازين، غلظت پلاسمايي و سميت اين دارو را افزايش دهند.


مصرف همزمان با پروپيل تيواوراسيل احتمال بروز آگرانولوسيتوز را افزايش مي‌ دهد. از استفاده همزمان پرهيز شود.


در صورت مصرف همزمان با ليتيم ممکن است مسموميت شديد نورولوژيک بروز کند و پاسخ درماني به کلرپرومازين کاهش يابد. از استفاده همزمان پرهيز شود.


کلرپرومازين مي‌ تواند اثر ضدانعقاد وارفارين را کاهش دهد. PT و INR چک شود.


کافئين مي‌ تواند فارماکوکينتيک دارو را تغيير داده و اثر درماني آن را کم کند. به بيماران توصيه کنيد از مصرف غذاها و نوشيدني‌هاي محتوي کافئين پرهيز کنند.


استفاده از الکل باعث افزايش دپرسيون سيستم اعصاب مرکزي، بويژه مهارتهاي سايکوموتور مي‌ شود.


سيگار کشيدن مي‌ تواند پاسخ به کلر پرومازين را کاهش دهد.


واکنشهاي حساسيت به نور مي‌ تواند به علت در معرض آفتاب قرار گرفتن اتفاق بيفتد.

فارماكوكینتیك

فارماكوكينتيك


جذب: سرعت و ميزان جذب اين دارو به طريقه مصرف آن بستگي دارد. جذب خوراكي آن نامنظم و متغير است و غلظت فرم خوراكي و شربت بيشتر قابل پيش بيني مي‌ باشد. جذب عضلاني اين دارو سريع است.


پخش: به طور گسترده در بدن، از جمله در شير، ‌انتشار مي‌ يابد. معمولاً غلظت اين دارو در CNS بيشتر از پلاسما است. غلظت پايدار سرمي آن طي 7-4 روز حاصل مي‌ شود. حدود 99-91 درصد به پروتئين پيوند مي‌ يابد.


متابوليسم: به طور عمده در كبد متابوليزه شده و به 12-10 متابوليت تبديل مي‌ شود، كه بعضي از اين متابوليتها فعال هستند.


دفع: بيشتر به صورت متابوليت از طريق كليه‌ها دفع شده و مقداري هم از طريق مجراي صفراوي و از مدفوع دفع مي‌ شود. اين دارو ممكن است به گردش روده‌اي ـ‌ كبدي وارد شود.

سایر اطلاعات

طبقه‌بندي فارماكولوژيك: فنوتيازين آليفاتيك.


طبقه‌بندي درماني: ضد سايكوز، ضد تهوع.


طبقه‌بندي مصرف در بارداري: رده C


نکات قابل توصيه به بيمار


احتمال بروز واکنش‌هاي ديستونيک و ديسکينزي ديررس وجود دارد. در صورت بروز حرکات غيرطبيعي بدن و انقباضات دردناک عضلاني فوراً به پزشک مراجعه کن يد.


از قرار گرفتن در برابر آفتاب خودداري کرده تا از واکنشها ي ناشي از حساسيت به نور جلوگيري شود (نور لامپ نيز ممکن است موجب تغيير رنگ پوست شود).


از حمام خيلي داغ و خيلي سرد و با قرار گرفتن در درجه حرارتهاي خيلي پايين يا خيلي بالا خوددار ي کنيد، زيرا اين دارو ممکن است موجب تغيير درجه حرارت بدن شود.


فرم خوراکي دارو مي‌ تواند ناراحتي گوارشي ا يجاد کند، به همين دليل مي‌ تواند با غذا يا مايعات خورده شود.


دارو را طبق دستور مصرف و در صورت فراموش کردن يک نوبت، از دو برابر کردن مقدار مصرف خودداري کنيد.


در صورت بروز اشکال در ادرار کردن، گلودرد، سرگيجه، و از حال رفتن به پزشک اطلاع دهيد.


از انجام فعاليت‌هاي مخاطره آميز که احتياج به هوشياري دارند ، پرهيز کنيد. اثرات رخوت زاي شديد اين دارو بعد از چند هفته قطع مي‌ شود.


براي برطرف کردن خشکي دهان مي‌ توان از آب نبات، آدامس و يا تکه‌هاي يخ استفاده کرد.


دارو را به صورت ناگهاني قطع نکنيد.


مصرف در سالمندان: بيماران سالخورده به مقدار کمتري از اين دارو احتياج دارند. مقدار مصرف براي هر بيمار به طور جداگانه تنظيم مي‌ شود. امکان بروز عوارض جانبي، بخصوص ديسکينزي ديررس و ديگر اثرات اکستراپيراميدال، در بيماران سالخورده بيشتر است.


مصرف در کودکان: مصرف کلرپرومازين در کودکان کوچکتر از شش ماه توصيه نمي‌ شود. سندرم مرگ ناگهاني شيرخوار در کودکان کوچکتر از يک سال که از اين دارو استفاده مي‌ کردند، گزارش شده است. اثرات اکستراپيراميدال در بچه‌ها شايع تر است.


مصرف در شيردهي: کلرپرومازين در شير مادر ترشح مي‌ شود. منافع اين دارو در برابر مضرات آن بايد سنجيده شود.


ملاحظات اختصاصي


علاوه بر ملاحظات مربوط به تمامي فنوت يازينها، رعايت موارد زير توصيه مي‌ شود:


در صورت تحريک بافت مي‌ توان محلول تزريقي کلرپرومازين را با محلول نمکي نرمال و با پروکائين دو درصد رقيق کرد.


اين دارو فقط در مواقع جراحي يا سکسکه‌هاي شديد تزريق وريدي شود.


محلول تزريقي با محلول نمکي نرمال تا غلظت 1 ليتر رقيق شده و با سرعت 1mg/2min براي کودکان و mg/min 1 براي بزرگسالان تزريق مي‌ شود.


تزريق عضلاني اين دارو بايد به طور عمقي در ربع فوقاني - خارجي عضله سريني صورت گيرد. تزريق، معمولاً دردناک است. ماساژ دادن محل تزريق از تشکيل آبسه جلوگيري مي‌ کند.


در صورت تماس شکل تزريقي و مايع کلرپرومازين با پوست، امکان بروز بثورات پوستي وجود دارد.


محلول تزريقي کلرپرومازين ممکن است اندکي تغيير رنگ دهد. در صورت تغيير رنگ شديد و يا وجود رسوبات، از مصرف دارو خودداري شود.


بيمار از لحاظ علائم و نشانه‌هاي ديسکينزي تأخيري بررسي شود.


CBC بيماراني که به مدت طولاني تحت درمان هستند ، چک شود.


بيمار براي بررسي علائم زردي انسدادي شامل درد بالا ي شکم ، تهوع، پوست زرد، علائم شبيه سرماخوردگي، بثورات جلدي، تب، ائوزينوفيلي، وجود صفرا در ادرار، افزايش بيلي روبين سرم، آلکالن فسفاتاز و ترانس آمينازها کنترل شود. تست هفتگي بيلي روبين ادرار در ماه اول درمان ممکن است زردي انسدادي را نشان دهد.


اثر بر آزمايشهاي تشخيصي


کلرپرومازين در پاسخ آزمونهاي ادرار براي پورفيرين، اوروبيلي نوژن ، آميلاز، 5- هيدروکسي ايندول استيک اسيد (5-HIAA) نتايج مثبت کاذب ايجاد مي‌ کند. زيرا متابوليت‌هاي اين دارو موجب نتايج مثبت کاذب مي‌شود.


کلرپرومازين مي‌ تواند شمارش ائوزينوفيل و آنزيم‌هاي کبدي را افزايش و سطح هموگلوبين و هماتوکريت و شمارش گلبول‌هاي سفيد، گرانولوسيتها و پلاکتها را کاهش دهد.

Chlorpromazine (Thorazine)

THORAZINE®
brand of chlorpromazine antipsychotic• tranquilizer • antiemetic

DRUG DESCRIPTION

Thorazine (chlorpromazine) is 10-(3-dimethylaminopropyl)-2-chlorphenothiazine, a dimethylamine derivative of phenothiazine. It is present in oral and injectable forms as the hydrochloride salt, and in the suppositories as the base.

THORAZINE® (chlorpromazine)   Structural Formula Illustration

Tablets — Each round, orange, coated tablet contains chlorpromazine hydrochloride as follows: 10 mg imprinted SKF and T73; 25 mg imprinted SKF and T74; 50 mg imprinted SKF and T76; 100 mg imprinted SKF and T77; 200 mg imprinted SKF and T79. Inactive ingredients consist of benzoic acid, croscarmellose sodium, D&C Yellow No. 10, FD&C Blue No. 2, FD&C Yellow No. 6, gelatin, hydroxypropyl methylcellulose, lactose, magnesium stearate, methylparaben, polyethylene glycol, propylparaben, talc, titanium dioxide and trace amounts of other inactive ingredients.

Spansule® sustained release capsules — Each Thorazine (chlorpromazine) Spansule® capsule is so prepared that an initial dose is released promptly and the remaining medication is released gradually over a prolonged period.

Each capsule, with opaque orange cap and natural body, contains chlorpromazine hydrochloride as follows: 30 mg imprinted SKF and T63; 75 mg imprinted SKF and T64; 150 mg imprinted SKF and T66. Inactive ingredients consist of benzyl alcohol, calcium sulfate, cetylpyridinium chloride, FD&C Yellow No. 6, gelatin, glyceryl distearate, glyceryl monostearate, iron oxide, povidone, silicon dioxide, sodium lauryl sulfate, starch, sucrose, titanium dioxide, wax and trace amounts of other inactive ingredients.

Ampuls — Each mL contains, in aqueous solution, chlorpromazine hydrochloride, 25 mg; ascorbic acid, 2 mg; sodium bisulfite, 1 mg; sodium chloride, 6 mg; sodium sulfite, 1 mg.

Multi-Dose Vials — Each mL contains, in aqueous solution, chlorpromazine hydrochloride, 25 mg; ascorbic acid, 2 mg; sodium bisulfite, 1 mg; sodium chloride, 1 mg; sodium sulfite, 1 mg; benzyl alcohol, 2%, as a preservative.

Syrup — Each 5 mL (1 teaspoonful) of clear, orange-custard flavored liquid contains chlorpromazine hydrochloride, 10 mg. Inactive ingredients consist of citric acid, flavors, sodium benzoate, sodium citrate, sucrose and water.

Suppositories — Each suppository contains chlorpromazine, 25 or 100 mg, glycerin, glyceryl monopalmitate, glyceryl monostearate, hydrogenated coconut oil fatty acids and hydrogenated palm kernel oil fatty acids.

What are the possible side effects of chlorpromazine (Thorazine)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking chlorpromazine and call your doctor at once if you have a serious side effect such as:

  • twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
  • tremor (uncontrolled shaking), drooling, trouble swallowing, problems with balance or walking;
  • feeling restless, jittery, or agitated;
  • feeling like you might pass out;
  • seizure (black-out or...

Read All Potential Side Effects and See Pictures of Thorazine »

Last reviewed on RxList: 6/2/2008
This monograph has been modified to include the generic and brand name in many instances.

INDICATIONS

For the treatment of schizophrenia.

To control nausea and vomiting.

For relief of restlessness and apprehension before surgery.

For acute intermittent porphyria.

As an adjunct in the treatment of tetanus.

To control the manifestations of the manic type of manic-depressive illness.

For relief of intractable hiccups.

For the treatment of severe behavioral problems in children (1 to 12 years of age) marked by combativeness and/or explosive hyperexcitable behavior (out of proportion to immediate provocations), and in the short-term treatment of hyperactive children who show excessive motor activity with accompanying conduct disorders consisting of some or all of the following symptoms: impulsivity, difficulty sustaining attention, aggressivity, mood lability and poor frustration tolerance.

DOSAGE AND ADMINISTRATION

ADULTS

Adjust dosage to individual and the severity of his condition, recognizing that the milligram for milligram potency relationship among all dosage forms has not been precisely established clinically. It is important to increase dosage until symptoms are controlled. Dosage should be increased more gradually in debilitated or emaciated patients. In continued therapy, gradually reduce dosage to the lowest effective maintenance level, after symptoms have been controlled for a reasonable period.

In general, dosage recommendations for other oral forms of the drug may be applied to Spansule® brand sustained release capsules on the basis of total daily dosage in milligrams.

The 100 mg and 200 mg tablets are for use in severe neuropsychiatric conditions.

Increase parenteral dosage only if hypotension has not occurred. Before using I.M., see IMPORTANT NOTES ON INJECTION.

Elderly Patients — In general, dosages in the lower range are sufficient for most elderly patients. Since they appear to be more susceptible to hypotension and neuromuscular reactions, such patients should be observed closely. Dosage should be tailored to the individual, response carefully monitored, and dosage adjusted accordingly. Dosage should be increased more gradually in elderly patients.

Psychotic Disorders — Increase dosage gradually until symptoms are controlled. Maximum improvement may not be seen for weeks or even months. Continue optimum dosage for 2 weeks; then gradually reduce dosage to the lowest effective maintenance level. Daily dosage of 200 mg is not unusual. Some patients require higher dosages (e.g., 800 mg daily is not uncommon in discharged mental patients).

HOSPITALIZED PATIENTS: ACUTE SCHIZOPHRENIC OR MANIC STATES — I.M.: 25 mg (1 mL). If necessary, give additional 25 to 50 mg injection in 1 hour. Increase subsequent I.M. doses gradually over several days— up to 400 mg q4 to 6h in exceptionally severe cases— until patient is controlled. Usually patient becomes quiet and cooperative within 24 to 48 hours and oral doses may be substituted and increased until the patient is calm. 500 mg a day is generally sufficient. While gradual increases to 2,000 mg a day or more may be necessary, there is usually little therapeutic gain to be achieved by exceeding 1,000 mg a day for extended periods. In general, dosage levels should be lower in the elderly, the emaciated and the debilitated. LESS ACUTELY DISTURBED— Oral: 25 mg t.i.d. Increase gradually until effective dose is reached— usually 400 mg daily. OUTPATIENTS— Oral: 10 mg t.i.d. or q.i.d., or 25 mg b.i.d. or t.i.d. MORE SEVERE CASES— Oral: 25 mg t.i.d. After 1 or 2 days, daily dosage may be increased by 20 to 50 mg at semiweekly intervals until patient becomes calm and cooperative. PROMPT CONTROL OF SEVERE SYMPTOMS— I.M.: 25 mg (1 mL). If necessary, repeat in 1 hour. Subsequent doses should be oral, 25 to 50 mg t.i.d.

Nausea and Vomiting — Oral: 10 to 25 mg q4 to 6h, p.r.n., increased, if necessary. I.M.: 25 mg (1 mL). If no hypotension occurs, give 25 to 50 mg q3 to 4h, p.r.n., until vomiting stops. Then switch to oral dosage. Rectal: One 100 mg suppository q6 to 8h, p.r.n. In some patients, half this dose will do.

DURING SURGERY— I.M.: 12.5 mg (0.5 mL). Repeat in 1 / 2 hour if necessary and if no hypotension occurs. I.V.: 2 mg per fractional injection, at 2-minute intervals. Do not exceed 25 mg. Dilute to 1 mg/mL, i.e., 1 mL (25 mg) mixed with 24 mL of saline.

Presurgical Apprehension — Oral: 25 to 50 mg, 2 to 3 hours before the operation. I.M.: 12.5 to 25 mg (0.5 to 1 mL), 1 to 2 hours before operation.

Intractable HiccupsOral: 25 to 50 mg t.i.d. or q.i.d. If symptoms persist for 2 to 3 days, give 25 to 50 mg (1 to 2 mL) I.M. Should symptoms persist, use slow I.V. infusion with patient flat in bed: 25 to 50 mg (1 to 2 mL) in 500 to 1,000 mL of saline. Follow blood pressure closely.

Acute Intermittent Porphyria — Oral: 25 to 50 mg t.i.d. or q.i.d. Can usually be discontinued after several weeks, but maintenance therapy may be necessary for some patients. I.M.: 25 mg (1 mL) t.i.d. or q.i.d. until patient can take oral therapy.

Tetanus — I.M.: 25 to 50 mg (1 to 2 mL) given 3 or 4 times daily, usually in conjunction with barbiturates. Total doses and frequency of administration must be determined by the patient's response, starting with low doses and increasing gradually. I.V.: 25 to 50 mg (1 to 2 mL). Dilute to at least 1 mg per mL and administer at a rate of 1 mg per minute.

DOSAGE AND ADMINISTRATION— PEDIATRIC PATIENTS (6 months to 12 years of age)

Thorazine (chlorpromazine) should generally not be used in pediatric patients under 6 months of age except where potentially lifesaving. It should not be used in conditions for which specific pediatric dosages have not been established.

Severe Behavioral Problems — OUTPATIENTS— Select route of administration according to severity of patient's condition and increase dosage gradually as required. Oral: 1 / 4 mg/lb body weight q4 to 6h, p.r.n. (e.g., for 40 lb child— 10 mg q4 to 6h). Rectal: 1 / 2 mg/lb body weight q6 to 8h, p.r.n. (e.g., for 20 to 30 lb child— half a 25 mg suppository q6 to 8h). I.M.: 1 / 4 mg/lb body weight q6 to 8h, p.r.n.

HOSPITALIZED PATIENTS— As with outpatients, start with low doses and increase dosage gradually. In severe behavior disorders, higher dosages (50 to 100 mg daily, and in older children, 200 mg daily or more) may be necessary. There is little evidence that behavior improvement in severely disturbed mentally retarded patients is further enhanced by doses beyond 500 mg per day. Maximum I.M. Dosage: Children up to 5 years (or 50 lbs), not over 40 mg/day; 5 to 12 years (or 50 to 100 lbs), not over 75 mg/day except in unmanageable cases.

Nausea and Vomiting — Dosage and frequency of administration should be adjusted according to the severity of the symptoms and response of the patient. The duration of activity following intramuscular administration may last up to 12 hours. Subsequent doses may be given by the same route if necessary. Oral: 1 / 4 mg/lb body weight (e.g., 40 lb child— 10 mg q4 to 6h). Rectal: 1 / 2 mg/lb body weight q6 to 8h, p.r.n. (e.g., 20 to 30 lb child— half of a 25 mg suppository q6 to 8h). I.M.: 1 / 4 mg/lb body weight q6 to 8h, p.r.n. Maximum I.M. Dosage: Pediatric patients 6 months to 5 yrs. (or 50 lbs), not over 40 mg/day; 5 to 12 yrs. (or 50 to 100 lbs), not over 75 mg/day except in severe cases. DURING SURGERY— I.M.: 1 / 8 mg/lb body weight. Repeat in 1 / 2 hour if necessary and if no hypotension occurs. I.V.: 1 mg per fractional injection at 2-minute intervals and not exceeding recommended I.M. dosage. Always dilute to 1 mg/ mL, i.e., 1 mL (25 mg) mixed with 24 mL of saline.

Presurgical Apprehension — 1 / 4 mg/lb body weight, either orally 2 to 3 hours before operation, or I.M. 1 to 2 hours before.

Tetanus — I.M. or I.V.: 1 / 4 mg/lb body weight q6 to 8h. When given I.V., dilute to at least 1 mg/mL and administer at rate of 1 mg per 2 minutes. In patients up to 50 lbs, do not exceed 40 mg daily; 50 to 100 lbs, do not exceed 75 mg, except in severe cases.

Important Notes On Injection

Inject slowly, deep into upper outer quadrant of buttock.

Because of possible hypotensive effects, reserve parenteral administration for bedfast patients or for acute ambulatory cases, and keep patient lying down for at least 1 / 2 hour after injection. If irritation is a problem, dilute Injection with saline or 2% procaine; mixing with other agents in the syringe is not recommended. Subcutaneous injection is not advised. Avoid injecting undiluted Thorazine (chlorpromazine) into vein. I.V. route is only for severe hiccups, surgery and tetanus.

Because of the possibility of contact dermatitis, avoid getting solution on hands or clothing. This solution should be protected from light. This is a clear, colorless to pale yellow solution; a slight yellowish discoloration will not alter potency. If markedly discolored, solution should be discarded. For information on sulfite sensitivity, see the WARNINGS section of this labeling.

Note on Concentrate: When the Concentrate is to be used, add the desired dosage of Concentrate to 60 mL (2 fl oz) or more of diluent just prior to administration. This will insure palatability and stability. Vehicles suggested for dilution are: tomato or fruit juice, milk, simple syrup, orange syrup, carbonated beverages, coffee, tea or water. Semisolid foods (soups, puddings, etc.) may also be used. The Concentrate is light sensitive; it should be protected from light and dispensed in amber glass bottles. Refrigeration is not required.

HOW SUPPLIED

Tablets: 10 mg, in bottles of 100; 25 mg or 50 mg, in bottles of 100 and 1000. For use in severe neuropsychiatric conditions, 100 mg and 200 mg, in bottles of 100 and 1000.

NDC 0007-5073-20 10 mg 100's
NDC 0007-5074-20 25 mg 100's
NDC 0007-5074-30 25 mg 1000's
NDC 0007-5076-20 50 mg 100's
NDC 0007-5076-30 50 mg 1000's
NDC 0007-5077-20 100 mg 100's
NDC 0007-5077-30 100 mg 1000's
NDC 0007-5079-20 200 mg 100's
NDC 0007-5079-30 200 mg 1000's

Spansule® brand of sustained release capsules: 30 mg, 75 mg or 150 mg, in bottles of 50.

NDC 0007-5063-15 30 mg 50's
NDC 0007-5064-15 75 mg 50's
NDC 0007-5066-15 150 mg 50's

Ampuls: 1 mL and 2 mL (25 mg/mL), in boxes of 10.

NDC 0007-5060-11 25 mg/mL in 1 mL Ampuls (box of 10)
NDC 0007-5061-11 25 mg/mL in 2 mL Ampuls (box of 10)

Multi-Dose Vials: 10 mL (25 mg/mL), in boxes of 1.

NDC 0007-5062-01 25 mg/mL in 10 mL Multi-Dose Vials (box of 1)

Syrup: 10 mg/5 mL, in 4 fl oz bottles.

NDC 0007-5072-44 10 mg/5 mL 4 fl oz

Suppositories: 25 mg or 100 mg, in boxes of 12.

NDC 0007-5070-03 25 mg (box of 12)
NDC 0007-5071-03 100 mg (box of 12)

All dosage forms except Syrup should be stored between 15° and 30°C (59° and 86°F). Syrup should be stored below 25°C (77°F).

*phenytoin, Parke-Davis.
† metrizamide, Sanofi Winthrop Pharmaceuticals.
‡ norepinephrine bitartrate, Sanofi Winthrop Pharmaceuticals.
§phenylephrine hydrochloride, Sanofi Winthrop Pharmaceuticals.
||
diphenhydramine hydrochloride, Parke-Davis.

WARNING: Thorazine® (chlorpromazine) Spansule capsules are manufactured with carbon tetrachloride and methyl chloroform, substances which harm public health and environment by destroying ozone in the upper atmosphere.

FDA revision date: 4/22/1998. Manufacturer information: n/a

Last reviewed on RxList: 6/2/2008
This monograph has been modified to include the generic and brand name in many instances.

SIDE EFFECTS

Note: Some adverse effects of Thorazine (chlorpromazine) may be more likely to occur, or occur with greater intensity, in patients with special medical problems, e.g., patients with mitral insufficiency or pheochromocytoma have experienced severe hypotension following recommended doses.

Drowsiness, usually mild to moderate, may occur, particularly during the first or second week, after which it generally disappears. If troublesome, dosage may be lowered.

B Overall incidence has been low, regardless of indication or dosage. Most investigators conclude it is a sensitivity reaction. Most cases occur between the second and fourth weeks of therapy. The clinical picture resembles infectious hepatitis, with laboratory features of obstructive jaundice, rather than those of parenchymal damage. It is usually promptly reversible on withdrawal of the medication; however, chronic jaundice has been reported.

There is no conclusive evidence that preexisting liver disease makes patients more susceptible to jaundice. Alcoholics with cirrhosis have been successfully treated with Thorazine (chlorpromazine) without complications. Nevertheless, the medication should be used cautiously in patients with liver disease. Patients who have experienced jaundice with a phenothiazine should not, if possible, be reexposed to Thorazine (chlorpromazine) or other phenothiazines.

If fever with grippe-like symptoms occurs, appropriate liver studies should be conducted. If tests indicate an abnormality, stop treatment.

Liver function tests in jaundice induced by the drug may mimic extrahepatic obstruction; withhold exploratory laparotomy until extrahepatic obstruction is confirmed.

Hematological Disorders, including agranulocytosis, eosinophilia, leukopenia, hemolytic anemia, aplastic anemia, thrombocytopenic purpura and pancytopenia have been reported.

Agranulocytosis — Warn patients to report the sudden appearance of sore throat or other signs of infection. If white blood cell and differential counts indicate cellular depression, stop treatment and start antibiotic and other suitable therapy.

Most cases have occurred between the fourth and tenth weeks of therapy; patients should be watched closely during that period.

Moderate suppression of white blood cells is not an indication for stopping treatment unless accompanied by the symptoms described above.

Cardiovascular

Hypotensive EffectsPostural hypotension, simple tachycardia, momentary fainting and dizziness may occur after the first injection; occasionally after subsequent injections; rarely, after the first oral dose. Usually recovery is spontaneous and symptoms disappear within 1 / 2 to 2 hours. Occasionally, these effects may be more severe and prolonged, producing a shock-like condition.

To minimize hypotension after injection, keep patient lying down and observe for at least 1 / 2 hour. To control hypotension, place patient in head-low position with legs raised. If a vasoconstrictor is required, Levophed® *** and Neo-Synephrine® § are the most suitable. Other pressor agents, including epinephrine, should not be used as they may cause a paradoxical further lowering of blood pressure.

EKG Changes — particularly nonspecific, usually reversible Q and T wave distortions— have been observed in some patients receiving phenothiazine tranquilizers, including Thorazine (chlorpromazine).

Note: Sudden death, apparently due to cardiac arrest, has been reported.

CNS Reactions

Neuromuscular (Extrapyramidal) Reactions — Neuromuscular reactions include dystonias, motor restlessness, pseudo-parkinsonism and tardive dyskinesia, and appear to be dose-related. They are discussed in the following paragraphs:

Dystonias: Symptoms may include spasm of the neck muscles, sometimes progressing to acute, reversible torticollis; extensor rigidity of back muscles, sometimes progressing to opisthotonos; carpopedal spasm, trismus, swallowing difficulty, oculogyric crisis and protrusion of the tongue.

These usually subside within a few hours, and almost always within 24 to 48 hours after the drug has been discontinued.

In mild cases, reassurance or a barbiturate is often sufficient. In moderate cases, barbiturates will usually bring rapid relief. In more severe adult cases, the administration of an anti-parkinsonism agent, except levodopa, usually produces rapid reversal of symptoms. In children (1 to 12 years of age), reassurance and barbiturates will usually control symptoms. (Or, parenteral Benadryl® ll may be useful. See Benadryl prescribing information for appropriate children's dosage.) If appropriate treatment with anti-parkinsonism agents or Benadryl fails to reverse the signs and symptoms, the diagnosis should be reevaluated.

Suitable supportive measures such as maintaining a clear airway and adequate hydration should be employed when needed. If therapy is reinstituted, it should be at a lower dosage. Should these symptoms occur in children or pregnant patients, the drug should not be reinstituted.

Motor Restlessness: Symptoms may include agitation or jitteriness and sometimes insomnia. These symptoms often disappear spontaneously. At times these symptoms may be similar to the original neurotic or psychotic symptoms. Dosage should not be increased until these side effects have subsided.

If these symptoms become too troublesome, they can usually be controlled by a reduction of dosage or change of drug. Treatment with anti-parkinsonian agents, benzodiazepines or propranolol may be helpful.

Pseudo-parkinsonism: Symptoms may include: mask-like facies, drooling, tremors, pillrolling motion, cogwheel rigidity and shuffling gait. In most cases these symptoms are readily controlled when an anti-parkinsonism agent is administered concomitantly. Anti-parkinsonism agents should be used only when required. Generally, therapy of a few weeks to 2 or 3 months will suffice. After this time patients should be evaluated to determine their need for continued treatment. (Note: Levodopa has not been found effective in antipsychotic-induced pseudo-parkinsonism.) Occasionally it is necessary to lower the dosage of Thorazine (chlorpromazine) or to discontinue the drug.

Tardive Dyskinesia: As with all antipsychotic agents, tardive dyskinesia may appear in some patients on long-term therapy or may appear after drug therapy has been discontinued. The syndrome can also develop, although much less frequently, after relatively brief treatment periods at low doses. This syndrome appears in all age groups. Although its prevalence appears to be highest among elderly patients, especially elderly women, it is impossible to rely upon prevalence estimates to predict at the inception of antipsychotic treatment which patients are likely to develop the syndrome. The symptoms are persistent and in some patients appear to be irreversible. The syndrome is characterized by rhythmical involuntary movements of the tongue, face, mouth or jaw (e.g., protrusion of tongue, puffing of cheeks, puckering of mouth, chewing movements). Sometimes these may be accompanied by involuntary movements of extremities. In rare instances, these involuntary movements of the extremities are the only manifestations of tardive dyskinesia. A variant of tardive dyskinesia, tardive dystonia, has also been described.

There is no known effective treatment for tardive dyskinesia; anti-parkinsonism agents do not alleviate the symptoms of this syndrome. If clinically feasible, it is suggested that all antipsychotic agents be discontinued if these symptoms appear. Should it be necessary to reinstitute treatment, or increase the dosage of the agent, or switch to a different antipsychotic agent, the syndrome may be masked.

It has been reported that fine vermicular movements of the tongue may be an early sign of the syndrome and if the medication is stopped at that time the syndrome may not develop.

Adverse Behavioral Effects — Psychotic symptoms and catatonic-like states have been reported rarely.

Other CNS EffectsNeuroleptic Malignant Syndrome (NMS) has been reported in association with antipsychotic drugs. (See WARNINGS.) Cerebral edema has been reported.

Convulsive seizures (petit mal and grand mal) have been reported, particularly in patients with EEG abnormalities or history of such disorders.

Abnormality of the cerebrospinal fluid proteins has also been reported.

Allergic Reactions of a mild urticarial type or photosensitivity are seen. Avoid undue exposure to sun. More severe reactions, including exfoliative dermatitis, have been reported occasionally.

Contact dermatitis has been reported in nursing personnel; accordingly, the use of rubber gloves when administering Thorazine (chlorpromazine) liquid or injectable is recommended.

In addition, asthma, laryngeal edema, angioneurotic edema and anaphylactoid reactions have been reported.

Endocrine Disorders: Lactation and moderate breast engorgement may occur in females on large doses. If persistent, lower dosage or withdraw drug. False-positive pregnancy tests have been reported, but are less likely to occur when a serum test is used. Amenorrhea and gynecomastia have also been reported. Hyperglycemia, hypoglycemia and glycosuria have been reported.

Autonomic Reactions: Occasional dry mouth; nasal congestion; nausea; obstipation; constipation; adynamic ileus; urinary retention; priapism; miosis and mydriasis, atonic colon, ejaculatory disorders/impotence.

Special Considerations in Long-Term Therapy: Skin pigmentation and ocular changes have occurred in some patients taking substantial doses of Thorazine (chlorpromazine) for prolonged periods.

Skin Pigmentation — Rare instances of skin pigmentation have been observed in hospitalized mental patients, primarily females who have received the drug usually for 3 years or more in dosages ranging from 500 mg to 1500 mg daily. The pigmentary changes, restricted to exposed areas of the body, range from an almost imperceptible darkening of the skin to a slate gray color, sometimes with a violet hue. Histological examination reveals a pigment, chiefly in the dermis, which is probably a melanin-like complex. The pigmentation may fade following discontinuance of the drug.

Ocular Changes — Ocular changes have occurred more frequently than skin pigmentation and have been observed both in pigmented and nonpigmented patients receiving Thorazine (chlorpromazine) usually for 2 years or more in dosages of 300 mg daily and higher. Eye changes are characterized by deposition of fine particulate matter in the lens and cornea. In more advanced cases, star-shaped opacities have also been observed in the anterior portion of the lens. The nature of the eye deposits has not yet been determined. A small number of patients with more severe ocular changes have had some visual impairment. In addition to these corneal and lenticular changes, epithelial keratopathy and pigmentary retinopathy have been reported. Reports suggest that the eye lesions may regress after withdrawal of the drug.

Since the occurrence of eye changes seems to be related to dosage levels and/or duration of therapy, it is suggested that long-term patients on moderate to high dosage levels have periodic ocular examinations.

Etiology — The etiology of both of these reactions is not clear, but exposure to light, along with dosage/duration of therapy, appears to be the most significant factor. If either of these reactions is observed, the physician should weigh the benefits of continued therapy against the possible risks and, on the merits of the individual case, determine whether or not to continue present therapy, lower the dosage, or withdraw the drug.

Other Adverse Reactions: Mild fever may occur after large I.M. doses. Hyperpyrexia has been reported. Increases in appetite and weight sometimes occur. Peripheral edema and a systemic lupus erythematosus-like syndrome have been reported.

Note: There have been occasional reports of sudden death in patients receiving phenothiazines. In some cases, the cause appeared to be cardiac arrest or asphyxia due to failure of the cough reflex.

Read the Thorazine (chlorpromazine) Side Effects Center for a complete guide to possible side effects »

DRUG INTERACTIONS

No information provided.

Last reviewed on RxList: 6/2/2008
This monograph has been modified to include the generic and brand name in many instances.

WARNINGS

The extrapyramidal symptoms which can occur secondary to Thorazine (chlorpromazine) may be confused with the central nervous system signs of an undiagnosed primary disease responsible for the vomiting, e.g., Reye's syndrome or other encephalopathy. The use of Thorazine (chlorpromazine) and other potential hepatotoxins should be avoided in children and adolescents whose signs and symptoms suggest Reye's syndrome.

Tardive Dyskinesia: Tardive dyskinesia, a syndrome consisting of potentially irreversible, involuntary, dyskinetic movements, may develop in patients treated with antipsychotic drugs. Although the prevalence of the syndrome appears to be highest among the elderly, especially elderly women, it is impossible to rely upon prevalence estimates to predict, at the inception of antipsychotic treatment, which patients are likely to develop the syndrome. Whether antipsychotic drug products differ in their potential to cause tardive dyskinesia is unknown.

Both the risk of developing the syndrome and the likelihood that it will become irreversible are believed to increase as the duration of treatment and the total cumulative dose of antipsychotic drugs administered to the patient increase. However, the syndrome can develop, although much less commonly, after relatively brief treatment periods at low doses.

There is no known treatment for established cases of tardive dyskinesia, although the syndrome may remit, partially or completely, if antipsychotic treatment is withdrawn. Antipsychotic treatment itself, however, may suppress (or partially suppress) the signs and symptoms of the syndrome and thereby may possibly mask the underlying disease process. The effect that symptomatic suppression has upon the long-term course of the syndrome is unknown.

Given these considerations, antipsychotics should be prescribed in a manner that is most likely to minimize the occurrence of tardive dyskinesia. Chronic antipsychotic treatment should generally be reserved for patients who suffer from a chronic illness that, 1) is known to respond to antipsychotic drugs, and, 2) for whom alternative, equally effective, but potentially less harmful treatments are not available or appropriate. In patients who do require chronic treatment, the smallest dose and the shortest duration of treatment producing a satisfactory clinical response should be sought. The need for continued treatment should be reassessed periodically.

If signs and symptoms of tardive dyskinesia appear in a patient on antipsychotics, drug discontinuation should be considered. However, some patients may require treatment despite the presence of the syndrome.

For further information about the description of tardive dyskinesia and its clinical detection, please refer to the sections on PRECAUTIONS and ADVERSE REACTIONS.

Neuroleptic Malignant Syndrome (NMS): A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome (NMS) has been reported in association with antipsychotic drugs. Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability (irregular pulse or blood pressure, tachycardia, diaphoresis and cardiac dysrhythmias).

The diagnostic evaluation of patients with this syndrome is complicated. In arriving at a diagnosis, it is important to identify cases where the clinical presentation includes both serious medical illness (e.g., pneumonia, systemic infection, etc.) and untreated or inadequately treated extrapyramidal signs and symptoms (EPS). Other important considerations in the differential diagnosis include central anticholinergic toxicity, heat stroke, drug fever and primary central nervous system (CNS) pathology.

The management of NMS should include 1) immediate discontinuation of antipsychotic drugs and other drugs not essential to concurrent therapy, 2) intensive symptomatic treatment and medical monitoring, and 3) treatment of any concomitant serious medical problems for which specific treatments are available. There is no general agreement about specific pharmacological treatment regimens for uncomplicated NMS.

If a patient requires antipsychotic drug treatment after recovery from NMS, the potential reintroduction of drug therapy should be carefully considered. The patient should be carefully monitored, since recurrences of NMS have been reported.

An encephalopathic syndrome (characterized by weakness, lethargy, fever, tremulousness and confusion, extrapyramidal symptoms, leukocytosis, elevated serum enzymes, BUN and FBS) has occurred in a few patients treated with lithium plus an antipsychotic. In some instances, the syndrome was followed by irreversible brain damage. Because of a possible causal relationship between these events and the concomitant administration of lithium and antipsychotics, patients receiving such combined therapy should be monitored closely for early evidence of neurologic toxicity and treatment discontinued promptly if such signs appear. This encephalopathic syndrome may be similar to or the same as neuroleptic malignant syndrome (NMS).

Thorazine (chlorpromazine) ampuls and multi-dose vials contain sodium bisulfite and sodium sulfite, sulfites that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people.

Patients with bone marrow depression or who have previously demonstrated a hypersensitivity reaction (e.g., blood dyscrasias, jaundice) with a phenothiazine should not receive any phenothiazine, including Thorazine (chlorpromazine) , unless in the judgment of the physician the potential benefits of treatment outweigh the possible hazard.

Thorazine (chlorpromazine) may impair mental and/or physical abilities, especially during the first few days of therapy. Therefore, caution patients about activities requiring alertness (e.g., operating vehicles or machinery).

The use of alcohol with this drug should be avoided due to possible additive effects and hypotension. Thorazine (chlorpromazine) may counteract the antihypertensive effect of guanethidine and related compounds.

Usage in Pregnancy: Safety for the use of Thorazine (chlorpromazine) during pregnancy has not been established. Therefore, it is not recommended that the drug be given to pregnant patients except when, in the judgment of the physician, it is essential. The potential benefits should clearly outweigh possible hazards. There are reported instances of prolonged jaundice, extrapyramidal signs, hyperreflexia or hyporeflexia in newborn infants whose mothers received phenothiazines.

Reproductive studies in rodents have demonstrated potential for embryotoxicity, increased neonatal mortality and nursing transfer of the drug. Tests in the offspring of the drug-treated rodents demonstrate decreased performance. The possibility of permanent neurological damage cannot be excluded.

Nursing Mothers: There is evidence that chlorpromazine is excreted in the breast milk of nursing mothers. Because of the potential for serious adverse reactions in nursing infants from chlorpromazine, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

PRECAUTIONS

General

Given the likelihood that some patients exposed chronically to antipsychotics will develop tardive dyskinesia, it is advised that all patients in whom chronic use is contemplated be given, if possible, full information about this risk. The decision to inform patients and/or their guardians must obviously take into account the clinical circumstances and the competency of the patient to understand the information provided.

Thorazine (chlorpromazine) should be administered cautiously to persons with cardiovascular, liver or renal disease. There is evidence that patients with a history of hepatic encephalopathy due to cirrhosis have increased sensitivity to the CNS effects of Thorazine (chlorpromazine) (i.e., impaired cerebration and abnormal slowing of the EEG).

Because of its CNS depressant effect, Thorazine (chlorpromazine) should be used with caution in patients with chronic respiratory disorders such as severe asthma, emphysema and acute respiratory infections, particularly in children (1 to 12 years of age).

Because Thorazine (chlorpromazine) can suppress the cough reflex, aspiration of vomitus is possible.

Thorazine (chlorpromazine) prolongs and intensifies the action of CNS depressants such as anesthetics, barbiturates and narcotics. When Thorazine (chlorpromazine) is administered concomitantly, about 1 / 4 to 1 / 2 the usual dosage of such agents is required. When Thorazine (chlorpromazine) is not being administered to reduce requirements of CNS depressants, it is best to stop such depressants before starting Thorazine (chlorpromazine) treatment. These agents may subsequently be reinstated at low doses and increased as needed.

Note: Thorazine (chlorpromazine) does not intensify the anticonvulsant action of barbiturates. Therefore, dosage of anticonvulsants, including barbiturates, should not be reduced if Thorazine (chlorpromazine) is started. Instead, start Thorazine (chlorpromazine) at low doses and increase as needed.

Use with caution in persons who will be exposed to extreme heat, organophosphorus insecticides, and in persons receiving atropine or related drugs.

Antipsychotic drugs elevate prolactin levels; the elevation persists during chronic administration. Tissue culture experiments indicate that approximately 1 / 3 of human breast cancers are prolactin-dependent in vitro, a factor of potential importance if the prescribing of these drugs is contemplated in a patient with a previously detected breast cancer. Although disturbances such as galactorrhea, amenorrhea, gynecomastia and impotence have been reported, the clinical significance of elevated serum prolactin levels is unknown for most patients. An increase in mammary neoplasms has been found in rodents after chronic administration of antipsychotic drugs. Neither clinical nor epidemiologic studies conducted to date, however, have shown an association between chronic administration of these drugs and mammary tumorigenesis; the available evidence is considered too limited to be conclusive at this time.

Chromosomal aberrations in spermatocytes and abnormal sperm have been demonstrated in rodents treated with certain antipsychotics.

As with all drugs which exert an anticholinergic effect, and/or cause mydriasis, chlorpromazine should be used with caution in patients with glaucoma.

Chlorpromazine diminishes the effect of oral anticoagulants.

Phenothiazines can produce alpha-adrenergic blockade.

Chlorpromazine may lower the convulsive threshold; dosage adjustments of anticonvulsants may be necessary. Potentiation of anticonvulsant effects does not occur. However, it has been reported that chlorpromazine may interfere with the metabolism of Dilantin® * and thus precipitate Dilantin toxicity.

Concomitant administration with propranolol results in increased plasma levels of both drugs.

Thiazide diuretics may accentuate the orthostatic hypotension that may occur with phenothiazines.

The presence of phenothiazines may produce false-positive phenylketonuria (PKU) test results.

Drugs which lower the seizure threshold, including phenothiazine derivatives, should not be used with Amipaque®† . As with other phenothiazine derivatives, Thorazine (chlorpromazine) should be discontinued at least 48 hours before myelography, should not be resumed for at least 24 hours postprocedure, and should not be used for the control of nausea and vomiting occurring either prior to myelography or postprocedure with Amipaque.

Long-Term Therapy: To lessen the likelihood of adverse reactions related to cumulative drug effect, patients with a history of long-term therapy with Thorazine (chlorpromazine) and/or other antipsychotics should be evaluated periodically to decide whether the maintenance dosage could be lowered or drug therapy discontinued.

Antiemetic Effect: The antiemetic action of Thorazine (chlorpromazine) may mask the signs and symptoms of overdosage of other drugs and may obscure the diagnosis and treatment of other conditions such as intestinal obstruction, brain tumor and Reye's syndrome. (See WARNINGS.)

When Thorazine (chlorpromazine) is used with cancer chemotherapeutic drugs, vomiting as a sign of the toxicity of these agents may be obscured by the antiemetic effect of Thorazine (chlorpromazine) .

Abrupt Withdrawal: Like other phenothiazines, Thorazine (chlorpromazine) is not known to cause psychic dependence and does not produce tolerance or addiction. There may be, however, following abrupt withdrawal of high-dose therapy, some symptoms resembling those of physical dependence such as gastritis, nausea and vomiting, dizziness and tremulousness. These symptoms can usually be avoided or reduced by gradual reduction of the dosage or by continuing concomitant anti-parkinsonism agents for several weeks after Thorazine (chlorpromazine) is withdrawn.

Last reviewed on RxList: 6/2/2008
This monograph has been modified to include the generic and brand name in many instances.

OVERDOSE

(See also ADVERSE REACTIONS.)

SYMPTOMS— Primarily symptoms of central nervous system depression to the point of somnolence or coma. Hypotension and extrapyramidal symptoms.

Other possible manifestations include agitation and restlessness, convulsions, fever, autonomic reactions such as dry mouth and ileus, EKG changes and cardiac arrhythmias.

TREATMENT— It is important to determine other medications taken by the patient since multiple drug therapy is common in overdosage situations. Treatment is essentially symptomatic and supportive. Early gastric lavage is helpful. Keep patient under observation and maintain an open airway, since involvement of the extrapyramidal mechanism may produce dysphagia and respiratory difficulty in severe overdosage. Do not attempt to induce emesis because a dystonic reaction of the head or neck may develop that could result in aspiration of vomitus. Extrapyramidal symptoms may be treated with anti-parkinsonism drugs, barbiturates, or Benadryl. See prescribing information for these products. Care should be taken to avoid increasing respiratory depression.

If administration of a stimulant is desirable, amphetamine, dextroamphetamine, or caffeine with sodium benzoate is recommended. Stimulants that may cause convulsions (e.g., picrotoxin or pentylenetetrazol) should be avoided.

If hypotension occurs, the standard measures for managing circulatory shock should be initiated. If it is desirable to administer a vasoconstrictor, Levophed and Neo-Synephrine are most suitable. Other pressor agents, including epinephrine, are not recommended because phenothiazine derivatives may reverse the usual elevating action of these agents and cause a further lowering of blood pressure.

Limited experience indicates that phenothiazines are not dialyzable.

Special note on Spansule® capsules — Since much of the Spansule capsule medication is coated for gradual release, therapy directed at reversing the effects of the ingested drug and at supporting the patient should be continued for as long as overdosage symptoms remain. Saline cathartics are useful for hastening evacuation of pellets that have not already released medication.

CONTRAINDICATIONS

Do not use in patients with known hypersensitivity to phenothiazines.

Do not use in comatose states or in the presence of large amounts of central nervous system depressants (alcohol, barbiturates, narcotics, etc.).

Last reviewed on RxList: 6/2/2008
This monograph has been modified to include the generic and brand name in many instances.

CLINICAL PHARMACOLOGY

ACTIONS

The precise mechanism whereby the therapeutic effects of chlorpromazine are produced is not known. The principal pharmacological actions are psychotropic. It also exerts sedative and antiemetic activity.

Chlorpromazine has actions at all levels of the central nervous system— primarily at subcortical levels— as well as on multiple organ systems. Chlorpromazine has strong antiadrenergic and weaker peripheral anticholinergic activity; ganglionic blocking action is relatively slight. It also possesses slight antihistaminic and antiserotonin activity.

Last reviewed on RxList: 6/2/2008
This monograph has been modified to include the generic and brand name in many instances.

PATIENT INFORMATION

No information provided. Please refer to the WARNINGS and PRECAUTIONS sections.

Last reviewed on RxList: 6/2/2008
This monograph has been modified to include the generic and brand name in many instances.

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PATIENT INFORMATION

No information provided. Please refer to the WARNINGS and PRECAUTIONS sections.

Last reviewed on RxList: 6/2/2008
This monograph has been modified to include the generic and brand name in many instances.

THORAZINE®
brand of chlorpromazine antipsychotic• tranquilizer • antiemetic

DRUG DESCRIPTION

Thorazine (chlorpromazine) is 10-(3-dimethylaminopropyl)-2-chlorphenothiazine, a dimethylamine derivative of phenothiazine. It is present in oral and injectable forms as the hydrochloride salt, and in the suppositories as the base.

THORAZINE® (chlorpromazine)   Structural Formula Illustration

Tablets — Each round, orange, coated tablet contains chlorpromazine hydrochloride as follows: 10 mg imprinted SKF and T73; 25 mg imprinted SKF and T74; 50 mg imprinted SKF and T76; 100 mg imprinted SKF and T77; 200 mg imprinted SKF and T79. Inactive ingredients consist of benzoic acid, croscarmellose sodium, D&C Yellow No. 10, FD&C Blue No. 2, FD&C Yellow No. 6, gelatin, hydroxypropyl methylcellulose, lactose, magnesium stearate, methylparaben, polyethylene glycol, propylparaben, talc, titanium dioxide and trace amounts of other inactive ingredients.

Spansule® sustained release capsules — Each Thorazine (chlorpromazine) Spansule® capsule is so prepared that an initial dose is released promptly and the remaining medication is released gradually over a prolonged period.

Each capsule, with opaque orange cap and natural body, contains chlorpromazine hydrochloride as follows: 30 mg imprinted SKF and T63; 75 mg imprinted SKF and T64; 150 mg imprinted SKF and T66. Inactive ingredients consist of benzyl alcohol, calcium sulfate, cetylpyridinium chloride, FD&C Yellow No. 6, gelatin, glyceryl distearate, glyceryl monostearate, iron oxide, povidone, silicon dioxide, sodium lauryl sulfate, starch, sucrose, titanium dioxide, wax and trace amounts of other inactive ingredients.

Ampuls — Each mL contains, in aqueous solution, chlorpromazine hydrochloride, 25 mg; ascorbic acid, 2 mg; sodium bisulfite, 1 mg; sodium chloride, 6 mg; sodium sulfite, 1 mg.

Multi-Dose Vials — Each mL contains, in aqueous solution, chlorpromazine hydrochloride, 25 mg; ascorbic acid, 2 mg; sodium bisulfite, 1 mg; sodium chloride, 1 mg; sodium sulfite, 1 mg; benzyl alcohol, 2%, as a preservative.

Syrup — Each 5 mL (1 teaspoonful) of clear, orange-custard flavored liquid contains chlorpromazine hydrochloride, 10 mg. Inactive ingredients consist of citric acid, flavors, sodium benzoate, sodium citrate, sucrose and water.

Suppositories — Each suppository contains chlorpromazine, 25 or 100 mg, glycerin, glyceryl monopalmitate, glyceryl monostearate, hydrogenated coconut oil fatty acids and hydrogenated palm kernel oil fatty acids.

Last reviewed on RxList: 6/2/2008
This monograph has been modified to include the generic and brand name in many instances.

THORAZINE®
brand of chlorpromazine antipsychotic• tranquilizer • antiemetic

DRUG DESCRIPTION

Thorazine (chlorpromazine) is 10-(3-dimethylaminopropyl)-2-chlorphenothiazine, a dimethylamine derivative of phenothiazine. It is present in oral and injectable forms as the hydrochloride salt, and in the suppositories as the base.

THORAZINE® (chlorpromazine)   Structural Formula Illustration

Tablets — Each round, orange, coated tablet contains chlorpromazine hydrochloride as follows: 10 mg imprinted SKF and T73; 25 mg imprinted SKF and T74; 50 mg imprinted SKF and T76; 100 mg imprinted SKF and T77; 200 mg imprinted SKF and T79. Inactive ingredients consist of benzoic acid, croscarmellose sodium, D&C Yellow No. 10, FD&C Blue No. 2, FD&C Yellow No. 6, gelatin, hydroxypropyl methylcellulose, lactose, magnesium stearate, methylparaben, polyethylene glycol, propylparaben, talc, titanium dioxide and trace amounts of other inactive ingredients.

Spansule® sustained release capsules — Each Thorazine (chlorpromazine) Spansule® capsule is so prepared that an initial dose is released promptly and the remaining medication is released gradually over a prolonged period.

Each capsule, with opaque orange cap and natural body, contains chlorpromazine hydrochloride as follows: 30 mg imprinted SKF and T63; 75 mg imprinted SKF and T64; 150 mg imprinted SKF and T66. Inactive ingredients consist of benzyl alcohol, calcium sulfate, cetylpyridinium chloride, FD&C Yellow No. 6, gelatin, glyceryl distearate, glyceryl monostearate, iron oxide, povidone, silicon dioxide, sodium lauryl sulfate, starch, sucrose, titanium dioxide, wax and trace amounts of other inactive ingredients.

Ampuls — Each mL contains, in aqueous solution, chlorpromazine hydrochloride, 25 mg; ascorbic acid, 2 mg; sodium bisulfite, 1 mg; sodium chloride, 6 mg; sodium sulfite, 1 mg.

Multi-Dose Vials — Each mL contains, in aqueous solution, chlorpromazine hydrochloride, 25 mg; ascorbic acid, 2 mg; sodium bisulfite, 1 mg; sodium chloride, 1 mg; sodium sulfite, 1 mg; benzyl alcohol, 2%, as a preservative.

Syrup — Each 5 mL (1 teaspoonful) of clear, orange-custard flavored liquid contains chlorpromazine hydrochloride, 10 mg. Inactive ingredients consist of citric acid, flavors, sodium benzoate, sodium citrate, sucrose and water.

Suppositories — Each suppository contains chlorpromazine, 25 or 100 mg, glycerin, glyceryl monopalmitate, glyceryl monostearate, hydrogenated coconut oil fatty acids and hydrogenated palm kernel oil fatty acids.

Last reviewed on RxList: 6/2/2008
This monograph has been modified to include the generic and brand name in many instances.

THORAZINE®
brand of chlorpromazine antipsychotic• tranquilizer • antiemetic

DRUG DESCRIPTION

Thorazine (chlorpromazine) is 10-(3-dimethylaminopropyl)-2-chlorphenothiazine, a dimethylamine derivative of phenothiazine. It is present in oral and injectable forms as the hydrochloride salt, and in the suppositories as the base.

THORAZINE® (chlorpromazine)   Structural Formula Illustration

Tablets — Each round, orange, coated tablet contains chlorpromazine hydrochloride as follows: 10 mg imprinted SKF and T73; 25 mg imprinted SKF and T74; 50 mg imprinted SKF and T76; 100 mg imprinted SKF and T77; 200 mg imprinted SKF and T79. Inactive ingredients consist of benzoic acid, croscarmellose sodium, D&C Yellow No. 10, FD&C Blue No. 2, FD&C Yellow No. 6, gelatin, hydroxypropyl methylcellulose, lactose, magnesium stearate, methylparaben, polyethylene glycol, propylparaben, talc, titanium dioxide and trace amounts of other inactive ingredients.

Spansule® sustained release capsules — Each Thorazine (chlorpromazine) Spansule® capsule is so prepared that an initial dose is released promptly and the remaining medication is released gradually over a prolonged period.

Each capsule, with opaque orange cap and natural body, contains chlorpromazine hydrochloride as follows: 30 mg imprinted SKF and T63; 75 mg imprinted SKF and T64; 150 mg imprinted SKF and T66. Inactive ingredients consist of benzyl alcohol, calcium sulfate, cetylpyridinium chloride, FD&C Yellow No. 6, gelatin, glyceryl distearate, glyceryl monostearate, iron oxide, povidone, silicon dioxide, sodium lauryl sulfate, starch, sucrose, titanium dioxide, wax and trace amounts of other inactive ingredients.

Ampuls — Each mL contains, in aqueous solution, chlorpromazine hydrochloride, 25 mg; ascorbic acid, 2 mg; sodium bisulfite, 1 mg; sodium chloride, 6 mg; sodium sulfite, 1 mg.

Multi-Dose Vials — Each mL contains, in aqueous solution, chlorpromazine hydrochloride, 25 mg; ascorbic acid, 2 mg; sodium bisulfite, 1 mg; sodium chloride, 1 mg; sodium sulfite, 1 mg; benzyl alcohol, 2%, as a preservative.

Syrup — Each 5 mL (1 teaspoonful) of clear, orange-custard flavored liquid contains chlorpromazine hydrochloride, 10 mg. Inactive ingredients consist of citric acid, flavors, sodium benzoate, sodium citrate, sucrose and water.

Suppositories — Each suppository contains chlorpromazine, 25 or 100 mg, glycerin, glyceryl monopalmitate, glyceryl monostearate, hydrogenated coconut oil fatty acids and hydrogenated palm kernel oil fatty acids.

Last reviewed on RxList: 6/2/2008
This monograph has been modified to include the generic and brand name in many instances.

Thorazine Patient Information Including Side Effects

Brand Names: Thorazine

Generic Name: chlorpromazine (oral) (Pronunciation: klor PROE ma zeen)

What is chlorpromazine (Thorazine)?

Chlorpromazine is an anti-psychotic medication in a group of drugs called phenothiazines (FEEN-oh-THYE-a-zeens). It works by changing the actions of chemicals in your brain.

Chlorpromazine is used to treat psychotic disorders such as schizophrenia or manic-depression, and severe behavioral problems in children. It is also used to treat nausea and vomiting, anxiety before surgery, chronic hiccups, acute intermittent porphyria, and symptoms of tetanus.

Chlorpromazine may also be used for purposes not listed in this medication guide.

Chlorpromazine 10 mg-GG

round, beige, imprinted with GG 455, 10

ChlorproMAZINE 10 mg-UPS

round, yellow, imprinted with 832 10

Chlorpromazine 100 mg-GG

round, brown, imprinted with GG 437, 100

ChlorproMAZINE 100 mg-UPS

round, yellow, imprinted with 832 100

Chlorpromazine 200 mg-GG

round, brown, imprinted with GG 457, 200

ChlorproMAZINE 200 mg-UPS

round, yellow, imprinted with 832 200

ChlorproMAZINE 25 mg-GG

round, yellow, imprinted with 25, GG 476

ChlorproMAZINE 25 mg-UPS

round, yellow, imprinted with 832 25

Chlorpromazine 50 mg-GG

round, brown, imprinted with GG 407, 50

ChlorproMAZINE 50 mg-UPS

round, yellow, imprinted with 832 50

What are the possible side effects of chlorpromazine (Thorazine)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking chlorpromazine and call your doctor at once if you have a serious side effect such as:

  • twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
  • tremor (uncontrolled shaking), drooling, trouble swallowing, problems with balance or walking;
  • feeling restless, jittery, or agitated;
  • feeling like you might pass out;
  • seizure (black-out or convulsions);
  • nausea upper stomach pain, itching, and jaundice (yellowing of the skin or eyes);
  • pale skin, easy bruising or bleeding, fever, sore throat, flu symptoms;
  • high fever, stiff muscles, confusion, sweating, fast or uneven heartbeats, rapid breathing;
  • unusual thoughts or behavior;
  • decreased night vision, tunnel vision, watery eyes, increased sensitivity to light;
  • urinating less than usual or not at all;
  • joint pain or swelling with fever, swollen glands, muscle aches, chest pain, vomiting, and patchy skin color; or
  • slow heart rate, weak pulse, fainting, slow breathing (breathing may stop).

Less serious side effects may include:

  • dizziness, drowsiness, anxiety, sleep problems (insomnia);
  • breast swelling or discharge;
  • changes in menstrual periods;
  • weight gain, swelling in your hands or feet;
  • dry mouth or stuffy nose, blurred vision;
  • constipation; or
  • impotence, trouble having an orgasm.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Thorazine (chlorpromazine) Side Effects Center for a complete guide to possible side effects »

What is the most important information I should know about chlorpromazine (Thorazine)?

Stop using this medication and call your doctor at once if you have twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. These could be early signs of dangerous side effects.

Chlorpromazine is not for use in psychotic conditions related to dementia. Chlorpromazine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.

Do not use chlorpromazine if you have brain damage, bone marrow depression, or are also using large amounts of alcohol or medicines that make you sleepy. Do not use if you are allergic to chlorpromazine or other phenothiazines.

Before you take chlorpromazine, tell your doctor if you have liver or kidney disease, heart disease or high blood pressure, glaucoma, severe breathing problems, past or present breast cancer, low levels of calcium in your blood, adrenal gland tumor, enlarged prostate or urination problems, a history of seizures, Parkinson's disease, or if you have ever had a serious side effect while using chlorpromazine or similar medicines.

Before taking chlorpromazine, tell your doctor about all other medications you use.

Side Effects Centers

Thorazine Patient Information including How Should I Take

What should I discuss with my healthcare provider before taking chlorpromazine (Thorazine)?

Chlorpromazine is not for use in psychotic conditions related to dementia. Chlorpromazine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.

Do not use chlorpromazine if you have brain damage, bone marrow depression, or are also using large amounts of alcohol or medicines that make you sleepy. Do not use if you are allergic to chlorpromazine or other phenothiazines such as fluphenazine (Permitil), perphenazine (Trilafon), prochlorperazine (Compazine, Compro), promethazine (Adgan, Pentazine, Phenergan), thioridazine (Mellaril), or trifluoperazine (Stelazine).

To make sure you can safely take chlorpromazine, tell your doctor if you have any of these other conditions:

  • liver or kidney disease;
  • heart disease or high blood pressure;
  • severe asthma, emphysema, or other breathing problem;
  • glaucoma;
  • past or present breast cancer;
  • low levels of calcium in your blood (hypocalcemia);
  • adrenal gland tumor (pheochromocytoma);
  • an enlarged prostate or urination problems;
  • a history of seizures;
  • Parkinson's disease; or
  • if you have ever had a serious side effect while using chlorpromazine or any other phenothiazine.

Tell your doctor if you will be exposed to extreme heat or cold, or to insecticide poisons while you are taking chlorpromazine.

Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking chlorpromazine, do not stop taking it without your doctor's advice.

Chlorpromazine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Talk with your doctor before giving this medication to a child who has been ill with a fever or flu symptoms.

Older adults may be more likely to have side effects from this medication.

How should I take chlorpromazine (Thorazine)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.

This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using chlorpromazine.

If you need to have any type of x-ray scan or MRI of your spinal cord, tell the doctor ahead of time that you are using chlorpromazine. You may need to stop using the medicine for a short time.

Do not stop using chlorpromazine suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using chlorpromazine.

Store at room temperature away from moisture and heat.

Side Effects Centers

Thorazine Patient Information including If I Miss a Dose

What happens if I miss a dose (Thorazine)?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose (Thorazine)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include dry mouth, constipation, bloating or stomach cramps, feeling restless or agitated, fever, seizure, muscle stiffness, jerky muscle movements, changes in heart rate, extreme drowsiness, and fainting.

What should I avoid while taking chlorpromazine (Thorazine)?

Chlorpromazine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Avoid drinking alcohol. It can increase some of the side effects of chlorpromazine.

Avoid exposure to sunlight or tanning beds. Chlorpromazine can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

What other drugs will affect chlorpromazine (Thorazine)?

Cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can interact with chlorpromazine and cause medical problems or increase side effects. Tell your doctor if you regularly use any of these medicines, or any other anti-psychotic medications.

Tell your doctor about all other medicines you use, especially:

  • atropine (Atreza, Sal-Tropine);
  • lithium (Eskalith, Lithobid);
  • phenytoin (Dilantin);
  • an antibiotic;
  • birth control pills or hormone replacement estrogens;
  • blood pressure medication;
  • a blood thinner such as warfarin (Coumadin, Jantoven);
  • certain asthma medications or bronchodilators;
  • incontinence medications;
  • insulin or diabetes medications you take by mouth;
  • medication for nausea, vomiting, or motion sickness;
  • medications to treat or prevent malaria;
  • medications used for general anesthesia;
  • medicines used to prevent organ transplant rejection;
  • numbing medicine such as lidocaine or Novocain;
  • a stimulant or ADHD medication;
  • ulcer or irritable bowel medications; or
  • medicines to treat Parkinson's disease, restless leg syndrome, or pituitary gland tumor (prolactinoma).

This list is not complete and there are many other medicines that can interact with chlorpromazine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about chlorpromazine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 12.01. Revision date: 3/14/2011.

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