کوریونیک گنادوتروپین
Chorionic Gonadotropin (Pregnyl)
کوریونیک گنادوتروپین

نام ژنریک

Chorionic Gonadotropin, H

شکل دارویی

اشكال دارويي:


Injection Powder: 500, 1500, 5000 IU

موارد مصرف

موارد و مقدار مصرف


الف) ايجاد تخمك‌گذاري و بارداري.


بزرگسالان: مقدار 10000-5000 واحد، يك روز پس از تزريق آخرين مقدار منوتروپين، تزريق عضلاني مي‌شود.


ب) هيپوگوناديسم هيپوگونادوتروپيك.


بزرگسالان: مقدار 1000-500 واحد سه بار در هفته به مدت سه هفته و بعد از آن دو بار در هفته به مدت سه هفته تزريق عضلاني مي‌شود و يا مقدار 4000 واحد سه بار در هفته به مدت 9-6 ماه و بعد از آن مقدار 2000 واحد سه بار در هفته به مدت سه ماه ديگر تزريق عضلاني مي‌شود.


پ) درمان نهفتگي غير انسدادي بيضه قبل از دوران بلوغ.


كودكان 9-4 ساله: مقدار 5000 واحد، يك روز در ميان، چهار بار و يا مقدار 4000 واحد سه بار در هفته به مدت سه هفته و يا مقدار 1000-500 واحد 15 بار طي شش هفته تزريق عضلاني مي‌شود يا 500 واحد، 3 بار در هفته به مدت 4 تا 6 هفته كه در صورت عدم پاسخ ظرف يك ماه، مي‌توان در هر تزريق مقدار 1000 واحد مصرف كرد.


مكانيسم اثر


اثر تحريك تخمك‌گذاري: گونادوتروپين كوريونيك انساني (HCG) با تقليد عمل LH موجب تخمك‌گذاري در فوليكول‌هاي رسيده تخمدان مي‌شود.


اثر تحريك اسپرم‌سازي: HCG توليد آندروژن را در سلول‌هاي ليديگ بيضه تحريك كرده و سبب بلوغ سلول‌هاي ديواره لوله‌هاي سمينيفر بيضه‌ها مي‌شود.

موارد منع مصرف

عوارض جانبي


اعصاب مرکزي: سردرد، خستگي، تحريك‌پذيري، بي‌قراري، افسردگي.


ادراري ـ تناسلي: بلوع زودرس (رشد بيضه‌ها، رشد آلت تناسلي، رشد موهاي ناحيه زهار و زير بغل، تغيير صدا، رشد موهاي بدن)، تحريك بيش از حد (بزرگي تخمدان‌ها)، پارگي كيست‌هاي تخمدان (بعد از مصرف گونادوتروپين‌ها).


موضعي: درد در محل تزريق.


ساير عوارض: ژنيكوماستي، ادم.

موارد قابل توجه

-

مکانیزم اثر

فارماكوكینتیك

موارد منع مصرف و احتياط


موارد منع مصرف: بلوغ زودرس يا سرطان وابسته به آندروژن (سرطان پروستات، بيضه و سرطان پستان در مردان) (چون دارو توليد آندروژن را تحريك مي‌كند)، حساسيت مفرط شناخته شده نسبت به آن.


موارد احتياط:


الف) آسم ، اختلالات تشنجي، ميگرن و بيماري‌هاي كليوي يا قلبي (موجب تشديد اين اختلالات مي‌شود).


ب) HCG بايد توسط پزشك متخصص تجويز شود.

سایر اطلاعات

طبقه‌بندي فارماكولوژيك: گونادوتروپين.


طبقه‌بندي درماني: محرك تخمك‌گذاري، محرك اسپرم‌سازي.


طبقه‌بندي مصرف در بارداري: رده X


ملاحظات اختصاصي


مردان جواني كه HCG مصرف مي‌كنند ، بايد از نظر بروز بلوغ زودرس تحت مراقبت قرار گيرند.


وضع بيماراني كه احتباس مايعات ممكن است موجب تشديد اختلالات آنها شود، بايد مورد توجه قرار گيرند.


در بارداري‌هاي بعد از تحريك تخمدان‌ها با گونادوتروپين‌ها، احتمال چندقلو زايي افزايش مي‌ يابد.


HCG معمولاً فقط پس از شكست درمان با كلوميفن مصرف مي‌شود.


در درمان نازايي، مقاربت روزانه از يك روز قبل از مصرف HCG تا زمان تخمك‌گذاري توصيه مي‌شود.


نشانه‌هاي بارداري خارج رحمي را بايد در نظر داشت. اين نشانه‌ها معمولاً بين هفته‌هاي 12-8 بعد از بارداري آشكار مي‌شوند.


نكات قابل توصيه به بيمار


در صورت بروز ادم، فوراً به پزشك اطلاع دهيد.


در صورت بروز علائم بلوغ زودرس، فوراً به پزشك اطلاع دهيد.


در صورت مصرف براي درمان ناباروري، احتمال چندقلوزايي وجود دارد.


مصرف در سالمندان: اين دارو در سالمندان مصرف نمي‌شود.


مصرف در كودكان: درمان نهفتگي بيضه قبل از سن بلوغ با HCG مي‌تواند نياز بعدي به اوركيدوپكسي را پيش‌بيني كند. القاي ترشح آندروژن ممكن است موجب بلوغ زودرس در بيماراني شود كه براي نهفتگي بيضه‌ها درمان مي‌شوند. به والدين اين كودكان بايد آموزش داد تا در صورت رشد موهاي زهار ، صورت و زير بغل، رشد آلت تناسلي، بروز آكنه و خشن شدن صدا در كودك خود، به پزشك اطلاع دهند.

Chorionic Gonadotropin (Pregnyl)

Pregnyl®
(chorionic gonadotropin for injection, USP)

DRUG DESCRIPTION

Human chorionic gonadotropin (HCG), a polypeptide hormone produced by the human placenta, is composed of an alpha and a beta sub-unit. The alpha sub-unit is essentially identical to the alpha subunits of the human pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as to the alpha sub-unit of human thyroid-stimulating hormone (TSH). The beta subunits of these hormones differ in amino acid sequence.

PREGNYL® (chorionic gonadotropin for injection, USP) is a highly purified pyrogen-free preparation obtained from the urine of pregnant females. It is standardized by a biological assay procedure. It is available for intramuscular injection in multiple dose vials containing 10,000 USP Units of sterile dried powder with 5 mg monobasic sodium phosphate and 4.4 mg dibasic sodium phosphate. If required, pH is adjusted with sodium hydroxide and/or phosphoric acid. Each package also contains a 10 mL vial of solvent containing: water for injection with 0.56% sodium chloride and 0.9% BENZYL ALCOHOL, WHICH IS NOT FOR USE IN NEWBORNS. If required, pH is adjusted with sodium hydroxide and/or hydrochloric acid.

What are the possible side effects of HCG (Novarel, Ovidrel, Pregnyl)?

Stop using HCG and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these signs of a blood clot: pain, warmth, redness, numbness, or tingling in your arm or leg; confusion, extreme dizziness, or severe headache.

Some women using this medicine have developed a condition called ovarian hyperstimulation syndrome (OHSS), especially after the first treatment cycle. OHSS can be a life-threatening condition....

Read All Potential Side Effects and See Pictures of Pregnyl »

What are the precautions when taking chorionic gonadotropin (Pregnyl)?

Before using this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: early puberty (in boys), male sex hormone-dependant cancer (e.g., prostate cancer) in boys.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart disease (e.g., congestive heart failure), kidney disease, seizures, asthma, migraine headaches.

This medication must not be used during pregnancy. If you become...

Read All Potential Precautions of Pregnyl »

Last reviewed on RxList: 6/13/2011
This monograph has been modified to include the generic and brand name in many instances.

INDICATIONS

HCG HAS NOT BEEN DEMONSTRATED TO BE EFFECTIVE ADJUNCTIVE THERAPY IN THE TREATMENT OF OBESITY. THERE IS NO SUBSTANTIAL EVIDENCE THAT IT INCREASES WEIGHT LOSS BEYOND THAT RESULTING FROM CALORIC RESTRICTION, THAT IT CAUSES A MORE ATTRACTIVE OR “NORMAL” DISTRIBUTION OF FAT, OR THAT IT DECREASES THE HUNGER AND DISCOMFORT ASSOCIATED WITH CALORIERESTRICTED DIETS.

  1. Prepubertal cryptorchidism not due to anatomical obstruction. In general, HCG is thought to induce testicular descent in situations when descent would have occurred at puberty. HCG thus may help predict whether or not orchiopexy will be needed in the future. Although, in some cases, descent following HCG administration is permanent, in most cases, the response is temporary. Therapy is usually instituted in children between the ages of 4 and 9.
  2. Selected cases of hypogonadotropic hypogonadism (hypogonadism secondary to a pituitary deficiency) in males.
  3. Induction of ovulation and pregnancy in the anovulatory, infertile woman in whom the cause of anovulation is secondary and not due to primary ovarian failure, and who has been appropriately pretreated with human menotropins.

DOSAGE AND ADMINISTRATION

For intramuscular use only. The dosage regimen employed in any particular case will depend upon the indication for the use, the age and weight of the patient, and the physician's preference. The following regimens have been advocated by various authorities:

Prepubertal cryptorchidism not due to anatomical obstruction. Therapy is usually instituted in children between the ages of 4 and 9
  1. 4,000 USP Units three times weekly for three weeks.
  2. 5,000 USP Units every second day for four injections.
  3. 15 injections for 500 to 1,000 USP Units over a period of six weeks.
  4. 500 USP Units three times weekly for four to six weeks. If this course of treatment is not successful, another series is begun one month later, giving 1,000 USP Units per injection.
Selected cases of hypogonadotropic hypogonadism in males
  1. 500 to 1,000 USP Units three times a week for three weeks, followed by the same dose twice a week for three weeks.
  2. 4,000 USP Units three times weekly for six to nine months, following which the dosage may be reduced to 2,000 USP Units three times weekly for an additional three months.
Induction of ovulation and pregnancy in the anovulatory, infertile woman in whom the cause of anovulation is secondary and not due to primary ovarian failure and who has been appropriately pretreated with human menotropins

(See prescribing information for menotropins for dosage and administration for that drug product.)

5,000 to 10,000 USP Units one day following the last dose of menotropins. (A dosage of 10,000 USP Units is recommended in the labeling for menotropins.)

Directions for Reconstitution

Two-vial package: Withdraw sterile air from lyophilized vial and inject into diluent vial. Remove 1–10 mL from diluent and add to lyophilized vial; agitate gently until powder is completely dissolved in solution.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

IMPORTANT: USE COMPLETELY AFTER RECONSTITUTION. RECONSTITUTED SOLUTION IS STABLE FOR 60 DAYS WHEN REFRIGERATED.

HOW SUPPLIED

Two-vial package containing:

1-10 mL lyophilized multiple dose vial containing: 10,000 USP Units chorionic gonadotropin per vial, NDC 0052-0315-10.

1-10 mL vial of solvent containing: water for injection with sodium chloride 0.56% and benzyl alcohol 0.9%, NDC 0052-0325-10.

When reconstituted, each 10 mL vial contains:

Chorionic gonadotropin 10,000 USP Units
Monobasic sodium phosphate 5 mg
Dibasic sodium phosphate 4.4 mg
Sodium chloride 0.56%
Benzyl alcohol 0.9%

If required pH adjusted with sodium hydroxide and/or phosphoric acid.

Storage

Store at controlled room temperature 15–30°C (59–86°F). Reconstituted solution is stable for 60 days when refrigerated.

Manufactured for Organon USA Inc. Roseland, NJ 07068 by Baxter Pharmaceutical Solutions LLC Bloomington, 4/11

Last reviewed on RxList: 6/13/2011
This monograph has been modified to include the generic and brand name in many instances.

SIDE EFFECTS

Headache, irritability, restlessness, depression, fatigue, edema, precocious puberty, gynecomastia, pain at the site of injection.

Hypersensitivity reactions, both localized and systemic in nature, have been reported.

Read the Pregnyl (chorionic gonadotropin) Side Effects Center for a complete guide to possible side effects »

DRUG INTERACTIONS

No information provided.

Last reviewed on RxList: 6/13/2011
This monograph has been modified to include the generic and brand name in many instances.

WARNINGS

HCG should be used in conjunction with human menopausal gonadotropins only by physicians experienced with infertility problems who are familiar with the criteria for patient selection, contraindications, warnings, precautions, and adverse reactions described in the package insert for menotropins.

Anaphylaxis has been reported with urinary-derived HCG products.

The principal serious adverse reactions during this use are:

(1) Ovarian hyperstimulation, a syndrome of sudden ovarian enlargement, ascites with or without pain, and/or pleural effusion, (2) Rupture of ovarian cysts with resultant hemoperitoneum, (3) Multiple births, and (4) Arterial thromboembolism.

PRECAUTIONS

General

Since androgens may cause fluid retention, HCG should be used with caution in patients with cardiac or renal disease, epilepsy, migraine, or asthma.

Pediatric Use

Induction of androgen secretion by HCG may induce precocious puberty in pediatric patients treated for cryptorchidism. Therapy should be discontinued if signs of precocious puberty occur.

Geriatric Use

Clinical studies of PREGNYL® (chorionic gonadotropin for injection, USP) did not include subjects aged 65 and over.

Last reviewed on RxList: 6/13/2011
This monograph has been modified to include the generic and brand name in many instances.

OVERDOSE

No information provided.

CONTRAINDICATIONS

Precocious puberty, prostatic carcinoma or other androgen-dependent neoplasm, prior allergic reaction to HCG.

Last reviewed on RxList: 6/13/2011
This monograph has been modified to include the generic and brand name in many instances.

CLINICAL PHARMACOLOGY

The action of HCG is virtually identical to that of pituitary LH, although HCG appears to have a small degree of FSH activity as well. It stimulates production of gonadal steroid hormones by stimulating the interstitial cells (Leydig cells) of the testis to produce androgens and the corpus luteum of the ovary to produce progesterone.

Androgen stimulation in the male leads to the development of secondary sex characteristics and may stimulate testicular descent when no anatomical impediment to descent is present. This descent is usually reversible when HCG is discontinued.

During the normal menstrual cycle, LH participates with FSH in the development and maturation of the normal ovarian follicle, and the mid-cycle LH surge triggers ovulation. HCG can substitute for LH in this function. During a normal pregnancy, HCG secreted by the placenta maintains the corpus luteum after LH secretion decreases, supporting continued secretion of estrogen and progesterone and preventing menstruation. HCG HAS NO KNOWN EFFECT ON FAT MOBILIZATION, APPETITE OR SENSE OF HUNGER, OR BODY FAT DISTRIBUTION.

Last reviewed on RxList: 6/13/2011
This monograph has been modified to include the generic and brand name in many instances.

PATIENT INFORMATION

No information provided. Please refer to the WARNINGS and PRECAUTIONS sections.

Last reviewed on RxList: 6/13/2011
This monograph has been modified to include the generic and brand name in many instances.

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PATIENT INFORMATION

No information provided. Please refer to the WARNINGS and PRECAUTIONS sections.

Last reviewed on RxList: 6/13/2011
This monograph has been modified to include the generic and brand name in many instances.

Disclaimer

Pregnyl Consumer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

GONADOTROPINS, CHORIONIC - INTRAMUSCULAR

(GO-nad-oh-TROW-pins, ko-ree-ON-ick)

COMMON BRAND NAME(S): A.P.L., Chorex, Pregnyl, Profasi

USES: This medication is a hormone used in boys (before puberty) to cause the normal dropping of the testicles into the scrotum. It is also used in certain boys to help with normal sexual development. It works by causing the testes to release male sex hormones (e.g., testosterone).

This medication is also used in women to treat fertility problems. It is given after finishing another medication (menotropins) to cause the release of an egg (ovulation). It should not be used in women whose ovaries no longer make eggs properly (primary ovarian failure).

This medication has not been shown to be effective for weight loss and should not be used for this purpose.

HOW TO USE: This medication is given by injection into a muscle by a health care professional. If you are giving this medication at home, learn all preparation and usage instructions for this product. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. If you have any questions about the use of this medication, ask your doctor or pharmacist.

The dosage is based on your age, weight, medical condition, and response to treatment.

For boys, use this medication usually 3 times a week or as directed by your doctor. For women, use this medication usually for 1 dose after finishing your menotropins treatment.

Use this medication regularly to get the most benefit from it. To help you remember, mark the day(s) on the calendar when you need to receive the medication.

Learn how to store and discard needles and medical supplies safely. Consult your pharmacist for more details.

Disclaimer

Pregnyl Consumer (continued)

SIDE EFFECTS: Headache, restlessness, tiredness, or pain at injection site may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: swelling of the ankles/feet, mental/mood changes (e.g., depression, irritability), signs of early puberty in boys (e.g., facial/pubic hair, voice change, acne), pain/swelling of the breast (in boys).

For women, when this medication is used with menotropins to treat infertility, also tell your doctor immediately if this unlikely but serious side effect occurs: abdominal pain/pressure/swelling.

For women, when this medication is used with menotropins to treat infertility, seek immediate medical attention if any of these rare but very serious side effects occur: chest pain, slurred speech, weakness on one side of the body, confusion.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing, shortness of breath.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the Pregnyl (chorionic gonadotropin) Side Effects Center for a complete guide to possible side effects »

PRECAUTIONS: Before using this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: early puberty (in boys), male sex hormone-dependant cancer (e.g., prostate cancer) in boys.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart disease (e.g., congestive heart failure), kidney disease, seizures, asthma, migraine headaches.

This medication must not be used during pregnancy. If you become pregnant or think you may be pregnant, tell your doctor immediately.

When this medication is used in females with menotropins to treat infertility, it may cause multiple births (e.g., twins, triplets).

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

Disclaimer

Pregnyl Consumer (continued)

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: gonadorelin.

This medication may interfere with certain laboratory tests (including luteinizing hormone-LH/follicle stimulating hormone-FSH levels), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center.

NOTES: Do not share this medication with others.

MISSED DOSE: If you miss a dose, contact your doctor or pharmacist immediately to establish a new dosing schedule.

STORAGE: Store the vials of powder at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Store the mixed medication in the refrigerator between 36-46 degrees F (2-8 degrees C). Write the date when the medication was mixed on the vial. The mixed medication must be used within 1 to 2 months, depending on the product. Check the product package for the storage time for your product. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised March 2012. Copyright(c) 2012 First Databank, Inc.

Pregnyl Patient Information Including Side Effects

Brand Names: Novarel, Ovidrel, Pregnyl

Generic Name: human chorionic gonadotropin (HCG) (injectable) (Pronunciation: HUE man KORE ee ON ik goe NAD oh TRO pin)

What is HCG (Pregnyl)?

Human chorionic gonadotropin (HCG) is a hormone that supports the normal development of an egg in a woman's ovary, and stimulates the release of the egg during ovulation.

HCG is used to cause ovulation and to treat infertility in women, and to increase sperm count in men. HCG is also used in young boys when their testicles have not dropped down into the scrotum normally. This can be caused by a pituitary gland disorder.

HCG may also be used for other purposes not listed in this medication guide.

What are the possible side effects of HCG (Pregnyl)?

Stop using HCG and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these signs of a blood clot: pain, warmth, redness, numbness, or tingling in your arm or leg; confusion, extreme dizziness, or severe headache.

Some women using this medicine have developed a condition called ovarian hyperstimulation syndrome (OHSS), especially after the first treatment cycle. OHSS can be a life-threatening condition. Call your doctor right away if you have any of the following symptoms of OHSS:

  • severe pelvic pain;
  • swelling of the hands or legs;
  • stomach pain and swelling;
  • shortness of breath;
  • weight gain;
  • diarrhea;
  • nausea or vomiting; or
  • urinating less than normal.

This medication can cause early puberty in young boys. Call your doctor if a boy using this medicine shows early signs of puberty, such as a deepened voice, pubic hair growth, and increased acne or sweating.

Less serious side effects may include:

  • headache;
  • feeling restless or irritable;
  • mild swelling or water weight gain;
  • depression;
  • breast tenderness or swelling; or
  • pain, swelling, or irritation where the injection is given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Pregnyl (chorionic gonadotropin) Side Effects Center for a complete guide to possible side effects »

What is the most important information I should know about HCG (Pregnyl)?

Human chorionic gonadotropin (HCG) is given as an injection under the skin or into a muscle. If you use this medicine at home, your doctor, nurse, or pharmacist will give you specific instructions on how and where to inject this medicine. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

Call your doctor at once if you have any of these signs of a blood clot: pain, warmth, redness, numbness, or tingling in your arm or leg; confusion, extreme dizziness, or severe headache.

Some women using this medicine have developed a condition called ovarian hyperstimulation syndrome (OHSS), especially after the first treatment cycle. OHSS can be a life-threatening condition. Call your doctor right away if you have any symptoms of OHSS: severe pelvic pain, swelling of the hands or legs, stomach pain and swelling, shortness of breath, weight gain, diarrhea, nausea or vomiting, and urinating less than normal.

HCG can cause early puberty in young boys. Call your doctor if a boy using this medicine shows early signs of puberty, such as a deepened voice, pubic hair growth, and increased acne or sweating.

Using this medicine can increase your chances of having a multiple pregnancy (twins, triplets, quadruplets, etc). A multiple pregnancy is a high-risk pregnancy for the mother and for the babies. Follow your doctor's instructions about any special care you may need during your pregnancy.

Although HCG can help you become pregnant, this medication is in the FDA pregnancy category X. This means that using the medication once you are pregnant can cause birth defects in the baby. Do not use this medication if you are pregnant. Tell your doctor right away if you become pregnant during treatment.

Side Effects Centers

Pregnyl Patient Information including How Should I Take

What should I discuss with my healthcare provider before using HCG (Pregnyl)?

You should not use this medication if you have ever had an allergic reaction to HCG, or if you have:

  • early puberty (also called precocious puberty); or
  • a hormone-related cancer (such as prostate cancer).

If you have any of these other conditions, you may need a dose adjustment or special tests to safely use this medication:

  • a thyroid or adrenal gland disorder;
  • an ovarian cyst;
  • premature puberty;
  • cancer or a tumor of the breast, ovary, uterus, prostate, hypothalamus, or pituitary gland;
  • undiagnosed uterine bleeding;
  • heart disease;
  • kidney disease;
  • epilepsy;
  • migraines; or
  • asthma.

Although HCG can help you become pregnant, this medication is in the FDA pregnancy category X. This means that using the medication once you are pregnant can cause birth defects in the baby. Do not use this medication if you are pregnant. Tell your doctor right away if you become pregnant during treatment.

It is not known whether HCG passes into breast milk. Do not use HCG without telling your doctor if you are breast-feeding a baby.

How should I use HCG (Pregnyl)?

Use this medication exactly as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

HCG is given as an injection under the skin or into a muscle. Your doctor, nurse, or other healthcare provider will give you this injection. You may be shown how to inject your medicine at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

Use each disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

To be sure this medication is helping your condition, your doctor will need to check you on a regular basis. Do not miss any scheduled appointments.

Some brands of HCG come in powder form with a separate liquid that you must mix together and draw into a syringe. Other brands are provided in single-dose prefilled syringes.

Do not use the medication if it has changed colors or the liquid has any particles in it. Call your doctor for a new prescription.

Store the powder form of HCG at room temperature away from light, moisture, and heat.

After mixing the powder with the liquid you must keep the mixture in the refrigerator. If you are using the Pregnyl brand of HCG, throw away any mixed medicine that you have not used within 60 days after mixing. If you are using the Novarel brand of HCG, throw away any mixed medicine that you have not used within 30 days after mixing.

Store Ovidrel prefilled syringes in the refrigerator. You may also store Ovidrel at room temperature protected from light, but you must use it within 30 days.

Side Effects Centers

Pregnyl Patient Information including If I Miss a Dose

What happens if I miss a dose (Pregnyl)?

Contact your doctor if you miss a dose of HCG.

What happens if I overdose (Pregnyl)?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of HCG is not expected to produce life-threatening symptoms.

What should I avoid while using HCG (Pregnyl)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are using HCG.

What other drugs will affect HCG (Pregnyl)?

There may be other drugs that can interact with HCG. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your doctor or pharmacist can provide more information about HCG.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 2.03. Revision date: 12/15/2010.

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